Detailed information for compound 887019

Basic information

Technical information
  • TDR Targets ID: 887019
  • Name: 3-[2-chloro-5-(trifluoromethyl)phenyl]-1-(oxo lan-2-ylmethyl)urea
  • MW: 322.711 | Formula: C13H14ClF3N2O2
  • H donors: 2 H acceptors: 1 LogP: 2.85 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(ccc1Cl)C(F)(F)F)NCC1CCCO1
  • InChi: 1S/C13H14ClF3N2O2/c14-10-4-3-8(13(15,16)17)6-11(10)19-12(20)18-7-9-2-1-5-21-9/h3-4,6,9H,1-2,5,7H2,(H2,18,19,20)
  • InChiKey: AMYHHEMOZNWBLK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-chloro-5-(trifluoromethyl)phenyl]-1-(tetrahydrofuran-2-ylmethyl)urea
  • 3-[2-chloro-5-(trifluoromethyl)phenyl]-1-(2-tetrahydrofuranylmethyl)urea
  • 3-[2-chloro-5-(trifluoromethyl)phenyl]-1-(tetrahydrofurfuryl)urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0143 0.0143
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1182 0.2266 0.3993
Schistosoma mansoni biogenic amine receptor 0.0038 0.0002 0.0002
Brugia malayi proprotein convertase 2 0.3615 0.7078 0.7078
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Schistosoma mansoni histamine h1 receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis protein will die slowly 0.0073 0.0071 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0038 0.0002 0.0002
Echinococcus multilocularis Mastin 0.0056 0.0037 0.0045
Brugia malayi Tubulin beta-1 chain 0.0091 0.0106 0.0106
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0002 0.0002
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0239 0.04 0.5
Schistosoma mansoni tubulin subunit beta 0.0091 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0183 0.0289 0.0289
Schistosoma mansoni amine GPCR 0.0038 0.0002 0.0002
Brugia malayi Will die slowly protein 0.0073 0.0071 0.0071
Trichomonas vaginalis tubulin epsilon chain, putative 0.0091 0.0106 0.0172
Echinococcus granulosus enteropeptidase 0.0056 0.0037 0.0035
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi putative neuropeptide receptor 0.0038 0.0002 0.0002
Plasmodium falciparum cysteine repeat modular protein 1 0.0061 0.0048 0.0822
Brugia malayi Trypsin family protein 0.0109 0.0143 0.0143
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0002 0.0002
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0016 0.0013
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0239 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Plasmodium falciparum subtilisin-like protease 1 0.0239 0.04 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0109 0.0143 0.0143
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1422 0.2739 0.483
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi Furin-like cysteine rich region family protein 0.0456 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Echinococcus granulosus wd40 repeat 0.0078 0.0081 0.0079
Brugia malayi GnHR receptor homolog 0.0038 0.0002 0.0002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0456 0.083 0.083
Loa Loa (eye worm) hypothetical protein 0.5093 1 1
Loa Loa (eye worm) tubulin beta chain 0.0091 0.0106 0.0106
Trichomonas vaginalis WD repeat domain, putative 0.0073 0.0071 0.011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Schistosoma mansoni hypothetical protein 0.0183 0.0289 0.0289
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.04 0.0692
Brugia malayi Dopamine receptor protein 1 0.0038 0.0002 0.0002
Schistosoma mansoni tubulin subunit beta 0.0091 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0239 0.04 0.5
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1422 0.2739 0.2739
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0038 0.0002 0.0002
Brugia malayi Serotonin receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0143 0.0143
Schistosoma mansoni amine GPCR 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Trypanosoma cruzi beta tubulin, putative 0.0091 0.0106 0.1665
Echinococcus multilocularis glycoprotein Antigen 5 0.0056 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Schistosoma mansoni retinoblastoma binding protein 0.0078 0.0081 0.0081
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0038 0.0002 0.0002
Schistosoma mansoni tubulin subunit beta 0.0091 0.0106 0.0106
Brugia malayi G-protein coupled receptor 0.0038 0.0002 0.0002
Brugia malayi Melatonin receptor type 1A 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.04 0.0692
Brugia malayi Dopamine receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0091 0.0106 0.0133
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0239 0.04 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0106 0.0133
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Trypanosoma cruzi subtilisin peptidase 0.0239 0.04 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Echinococcus granulosus neuroendocrine convertase 2 0.3615 0.7078 0.7077
Giardia lamblia High cysteine membrane protein Group 2 0.1578 0.3048 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis enteropeptidase 0.0056 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0078 0.0081 0.0081
Loa Loa (eye worm) SPRY domain-containing protein 0.0045 0.0016 0.0016
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0106 0.0104
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0239 0.04 1
Loa Loa (eye worm) G-protein coupled receptor 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1422 0.2739 0.483
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0106 0.0133
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0081 0.0127
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Echinococcus granulosus set1:ash2 histone methyltransferase complex 0.0045 0.0016 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Echinococcus granulosus beta tubulin 0.0091 0.0106 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.04 0.0692
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Echinococcus granulosus glycoprotein Antigen 5 0.0056 0.0037 0.0035
Loa Loa (eye worm) tubulin beta-2A chain 0.0091 0.0106 0.0106
Echinococcus granulosus Mastin 0.0056 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis tubulin gamma chain, putative 0.0091 0.0106 0.0172
Schistosoma mansoni amine GPCR 0.0038 0.0002 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni neuropeptide receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) tubulin beta-1 chain 0.0091 0.0106 0.0106
Toxoplasma gondii subtilisin SUB5 0.0239 0.04 0.9248
Plasmodium falciparum subtilisin-like protease 3 0.0239 0.04 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0109 0.0143 0.0143
Loa Loa (eye worm) subtilase 0.0239 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Echinococcus granulosus epidermal growth factor receptor 0.0456 0.083 0.0828
Mycobacterium leprae Possible secreted protease 0.0239 0.04 0.5
Schistosoma mansoni myosin xvIII 0.0038 0.0002 0.0002
Schistosoma mansoni furin-1 (S08 family) 0.2433 0.4739 0.4739
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0126 0.0207
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0239 0.04 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0239 0.04 0.04
Loa Loa (eye worm) proprotein convertase 2 0.1422 0.2739 0.2739
Trypanosoma brucei subtilisin peptidase 0.0239 0.04 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Loa Loa (eye worm) WD40 repeat protein 0.0073 0.0071 0.0071
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0106 0.0133
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0038 0.0002 0.0002
Echinococcus multilocularis tissue type plasminogen activator 0.0061 0.0048 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2899 0.5661 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0061 0.0048 0.0822
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0239 0.04 1
Brugia malayi celfurPC protein 0.4011 0.786 0.786
Schistosoma mansoni opsin-like receptor 0.0038 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni tyrosine kinase 0.0456 0.083 0.083
Echinococcus granulosus furin 0.5093 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni site-1 peptidase (S08 family) 0.0239 0.04 0.04
Brugia malayi G protein-coupled receptor F59B2.13 0.0038 0.0002 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0038 0.0002 0.0002
Toxoplasma gondii subtilisin SUB9 0.0239 0.04 0.9248
Brugia malayi Tachykinin-like peptides receptor 99D 0.0038 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0239 0.04 0.0506
Brugia malayi sulfakinin receptor protein 0.0038 0.0002 0.0002
Toxoplasma gondii beta-1 tubulin, putative 0.0091 0.0106 0.2301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Schistosoma mansoni neuropeptide receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.2899 0.5661 0.7201
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1082 0.2067 0.3642
Schistosoma mansoni neuropeptide receptor 0.0038 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0038 0.0002 0.0002
Toxoplasma gondii subtilisin SUB6 0.0239 0.04 0.9248
Onchocerca volvulus 0.0073 0.0071 0.1744
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0239 0.04 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0106 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.04 0.0692
Leishmania major subtilisin-like serine peptidase 0.0239 0.04 1
Onchocerca volvulus 0.0239 0.04 1
Toxoplasma gondii subtilisin SUB10 0.0239 0.04 0.9248
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0038 0.0002 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0038 0.0002 0.0002
Brugia malayi Serotonin receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0038 0.0002 0.0002
Toxoplasma gondii beta tubulin 0.0091 0.0106 0.2301
Loa Loa (eye worm) endoprotease bli-4 0.5093 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0038 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0061 0.0048 0.0048
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0038 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi larval opioid receptor 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Echinococcus multilocularis epidermal growth factor receptor 0.0456 0.083 0.1053
Echinococcus granulosus protein will die slowly 0.0073 0.0071 0.0069
Brugia malayi ORL1-like opioid receptor 0.0038 0.0002 0.0002
Plasmodium falciparum subtilisin-like protease 2 0.0239 0.04 1
Schistosoma mansoni hypothetical protein 0.0073 0.0071 0.0071
Schistosoma mansoni neuropeptide receptor 0.0038 0.0002 0.0002
Schistosoma mansoni neuropeptide f receptor 76f 0.0038 0.0002 0.0002
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0239 0.04 1
Schistosoma mansoni hypothetical protein 0.1082 0.2067 0.2067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni tubulin subunit beta 0.0091 0.0106 0.0106
Echinococcus multilocularis beta tubulin 0.0091 0.0106 0.0133
Schistosoma mansoni opsin-like receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0002 0.0002
Toxoplasma gondii subtilisin SUB2 0.0239 0.04 0.9248
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0239 0.04 0.5
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0239 0.04 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1422 0.2739 0.483
Toxoplasma gondii beta-tubulin, putative 0.0091 0.0106 0.2301
Echinococcus multilocularis Furin 1 0.1422 0.2739 0.3483
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0106 0.0133
Onchocerca volvulus 0.0092 0.0108 0.2671
Schistosoma mansoni trithorax protein ash2 0.0045 0.0016 0.0016
Brugia malayi putative neuropeptide receptor NPR1 0.0038 0.0002 0.0002
Toxoplasma gondii subtilisin SUB8 0.0239 0.04 0.9248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1422 0.2739 0.483
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0239 0.04 0.0398
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Schistosoma mansoni hypothetical protein 0.0038 0.0002 0.0002
Echinococcus multilocularis beta tubulin 0.0091 0.0106 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Schistosoma mansoni hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Echinococcus multilocularis 0.4011 0.786 1
Onchocerca volvulus 0.0061 0.0048 0.1148
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5093 1 1
Brugia malayi Kringle domain containing protein 0.0061 0.0048 0.0048
Echinococcus granulosus geminin 0.0183 0.0289 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Onchocerca volvulus 0.0109 0.0143 0.3534
Schistosoma mansoni hypothetical protein 0.0038 0.0002 0.0002
Echinococcus multilocularis neuroendocrine convertase 2 0.3615 0.7078 0.9005
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0106 0.0104
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Loa Loa (eye worm) BEN-1 protein 0.0091 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0078 0.0081 0.0081
Plasmodium vivax subtilisin-like serine protease, putative 0.0239 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0038 0.0002 0.0002
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Echinococcus multilocularis wd40 repeat 0.0078 0.0081 0.01
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) TK/ROR protein kinase 0.0061 0.0048 0.0048
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0106 0.0104
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0554 0.1024 0.1024
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Giardia lamblia Furin precursor putative serine protease 0.1182 0.2266 0.7341
Echinococcus granulosus tubulin beta 4A class IVa 0.0091 0.0106 0.0104
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.034 0.0599 0.0599
Echinococcus granulosus beta tubulin 0.0091 0.0106 0.0104
Brugia malayi follicle stimulating hormone receptor 0.0038 0.0002 0.0002
Toxoplasma gondii subtilisin SUB11 0.0239 0.04 0.9248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Echinococcus granulosus membrane bound transcription factor site 1 0.0239 0.04 0.0398
Onchocerca volvulus 0.0101 0.0126 0.3122
Echinococcus granulosus tubulin beta 1 chain 0.0091 0.0106 0.0104
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1422 0.2739 0.483
Brugia malayi RE15519p 0.0038 0.0002 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0034 0.0034
Brugia malayi G-protein coupled receptor 0.0038 0.0002 0.0002
Echinococcus granulosus Furin 1 0.1422 0.2739 0.2737
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis retinoblastoma binding protein, putative 0.0078 0.0081 0.0127
Echinococcus multilocularis set1:ash2 histone methyltransferase complex 0.0045 0.0016 0.0018
Trichomonas vaginalis tubulin, putative 0.0091 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.2294 0.4465 0.4465
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Loa Loa (eye worm) BEN-1 protein 0.0091 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0054 0.0034 0.0034
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0038 0.0002 0.0002
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0239 0.04 0.5
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Trichomonas vaginalis tubulin alpha chain, putative 0.0091 0.0106 0.0172
Toxoplasma gondii subtilisin SUB7 0.0239 0.04 0.9248
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0239 0.04 0.04
Schistosoma mansoni biogenic amine receptor 0.0038 0.0002 0.0002
Echinococcus multilocularis geminin 0.0183 0.0289 0.0366
Brugia malayi Protein kinase domain containing protein 0.0061 0.0048 0.0048
Echinococcus granulosus tissue type plasminogen activator 0.0061 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis tubulin epsilon chain, putative 0.0091 0.0106 0.0172
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Schistosoma mansoni tubulin subunit beta 0.0091 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Echinococcus granulosus Tubulin beta 2C chain 0.0091 0.0106 0.0104
Plasmodium vivax subtilisin-like protease 2, putative 0.0239 0.04 1
Brugia malayi SPRY domain containing protein 0.0045 0.0016 0.0016
Echinococcus multilocularis Tubulin beta 2C chain 0.0091 0.0106 0.0133
Loa Loa (eye worm) SPRY domain-containing protein 0.0041 0.0009 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0002 0.0002
Brugia malayi Subtilase family protein 0.0239 0.04 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.034 0.0599 0.1043
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Brugia malayi neuropeptide F receptor 0.0038 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Plasmodium vivax tubulin beta chain, putative 0.0091 0.0106 0.235
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Schistosoma mansoni site-1 peptidase (S08 family) 0.0239 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Plasmodium vivax subtilisin-like protease 1 0.0239 0.04 1
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0056 0.0037 0.0037
Brugia malayi neuropeptide F receptor 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.04 0.0692
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1422 0.2739 0.483
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Echinococcus multilocularis membrane bound transcription factor site 1 0.0239 0.04 0.0506
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Trichomonas vaginalis hypothetical protein 0.1082 0.2067 0.3642
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Toxoplasma gondii kringle domain-containing protein 0.0061 0.0048 0.0914
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Brugia malayi G protein-coupled receptor 0.0038 0.0002 0.0002
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2899 0.5661 1
Toxoplasma gondii subtilisin SUB12 0.0255 0.0432 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Echinococcus multilocularis tubulin beta 1 chain 0.0091 0.0106 0.0133
Entamoeba histolytica tubulin family protein 0.0091 0.0106 0.5
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Entamoeba histolytica tubulin family protein 0.0091 0.0106 0.5
Schistosoma mansoni amine GPCR 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1182 0.2266 0.3993
Brugia malayi beta-tubulin, identical 0.0091 0.0106 0.0106
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0239 0.04 0.5
Schistosoma mansoni hypothetical protein 0.0038 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Echinococcus multilocularis tubulin subunit beta 0.0091 0.0106 0.0133
Schistosoma mansoni biogenic amine (5HT) receptor 0.0038 0.0002 0.0002
Echinococcus granulosus tubulin subunit beta 0.0091 0.0106 0.0104
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0239 0.04 0.5
Toxoplasma gondii subtilisin SUB1 0.0239 0.04 0.9248
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0239 0.04 0.5
Loa Loa (eye worm) tubulin beta-4 chain 0.0091 0.0106 0.0106
Brugia malayi hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi AKH receptor 0.0038 0.0002 0.0002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0038 0.0002 0.0002
Brugia malayi Dopamine receptor protein 2 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni tubulin subunit beta 0.0091 0.0106 0.0106
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.2899 0.5661 0.566
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0038 0.0002 0.0002
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0034 0.0034
Leishmania major beta tubulin 0.0091 0.0106 0.1665
Brugia malayi neuroendocrine convertase 1 precursor 0.4069 0.7976 0.7976
Toxoplasma gondii subtilisin SUB4 0.0239 0.04 0.9248
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0038 0.0002 0.0002
Schistosoma mansoni adenoreceptor 0.0038 0.0002 0.0002
Plasmodium falciparum tubulin beta chain 0.0091 0.0106 0.235
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0239 0.04 0.0692
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0002 0.0002
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0038 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1082 0.2067 0.3642
Loa Loa (eye worm) hypothetical protein 0.0061 0.0048 0.0048
Schistosoma mansoni neuropeptide F-like receptor 0.0038 0.0002 0.0002
Trichomonas vaginalis tubulin beta chain, putative 0.0091 0.0106 0.0172
Loa Loa (eye worm) beta-tubulin 0.0091 0.0106 0.0106

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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