Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0192 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0136 | 0.0165 | 0.0165 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3237 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1497 | 0.448 | 0.3107 |
Schistosoma mansoni | P2X receptor subunit | 0.0192 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0192 | 0.0342 | 0.0342 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0261 | 0.0261 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3155 | 0.9741 | 0.5 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | dihydrofolate reductase | 0.3237 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | thymidylate synthase | 0.1497 | 0.448 | 0.448 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0261 | 0.0261 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | ACC-1 protein | 0.0136 | 0.0165 | 0.0165 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3237 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3155 | 0.9741 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0279 | 0.0619 | 0.0619 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3155 | 0.9741 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.0136 | 0.0165 | 0.0369 | |
Echinococcus granulosus | neuropeptide receptor | 0.0279 | 0.0619 | 0.0619 |
Brugia malayi | hypothetical protein | 0.0712 | 0.1992 | 0.1992 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0192 | 0.0342 | 0.0342 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.1497 | 0.448 | 1 | |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0192 | 0.0342 | 0.0342 |
Echinococcus granulosus | geminin | 0.0166 | 0.0261 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | P2X receptor subunit | 0.0192 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | thymidylate synthase | 0.1497 | 0.448 | 0.448 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3237 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | P2X receptor subunit | 0.0192 | 0.0342 | 0.0342 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | neuropeptide receptor | 0.0279 | 0.0619 | 0.0619 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0136 | 0.0165 | 0.0165 |
Onchocerca volvulus | Putative nachr subunit | 0.0136 | 0.0165 | 0.0369 |
Echinococcus multilocularis | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.0136 | 0.0165 | 0.0369 | |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Cation transporter family protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | LGC-31 protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0712 | 0.1992 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0279 | 0.0619 | 0.0619 |
Onchocerca volvulus | 0.0136 | 0.0165 | 0.0369 | |
Schistosoma mansoni | dihydrofolate reductase | 0.3237 | 1 | 1 |
Onchocerca volvulus | 0.0136 | 0.0165 | 0.0369 | |
Schistosoma mansoni | P2X receptor subunit | 0.0192 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3155 | 0.9741 | 0.5 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | thymidylate synthase | 0.1497 | 0.448 | 0.448 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | ACC-1 protein | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3237 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | thymidylate synthase | 0.1497 | 0.448 | 0.448 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3237 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1497 | 0.448 | 0.448 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0136 | 0.0165 | 0.0165 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3155 | 0.9741 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | nAChR subunit | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0136 | 0.0165 | 0.0165 |
Entamoeba histolytica | hypothetical protein | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0192 | 0.0342 | 0.0342 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0136 | 0.0165 | 0.0165 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0261 | 0.0261 |
Brugia malayi | Cation transporter family protein | 0.0136 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.0136 | 0.0165 | 0.0369 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3155 | 0.9741 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Dihydrofolate reductase | 0.3237 | 1 | 1 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0136 | 0.0165 | 0.0165 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0136 | 0.0165 | 0.0165 |
Onchocerca volvulus | 0.0136 | 0.0165 | 0.0369 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0136 | 0.0165 | 0.0165 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0192 | 0.0342 | 0.0342 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0136 | 0.0165 | 0.0165 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3237 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.