Detailed information for compound 887472

Basic information

Technical information
  • TDR Targets ID: 887472
  • Name: 3-(4-ethoxyphenyl)-2-(2-methoxyethylamino)fur o[3,2-c]chromen-4-one
  • MW: 379.406 | Formula: C22H21NO5
  • H donors: 1 H acceptors: 1 LogP: 4.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNc1oc2c(c1c1ccc(cc1)OCC)c(=O)oc1c2cccc1
  • InChi: 1S/C22H21NO5/c1-3-26-15-10-8-14(9-11-15)18-19-20(28-21(18)23-12-13-25-2)16-6-4-5-7-17(16)27-22(19)24/h4-11,23H,3,12-13H2,1-2H3
  • InChiKey: MOYFIVWEAKKSND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-ethoxyphenyl)-2-(2-methoxyethylamino)-4-furo[3,2-c]chromenone
  • ZINC07636150

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) serotonin transporter b 0.0062 0.1354 0.2051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0057 0.0087
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0091 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0272 0.6605 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.113 0.0358
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.088 0.6339
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Onchocerca volvulus 0.0012 0.0091 0.0258
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0947 0.0947
Onchocerca volvulus 0.0062 0.1354 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Brugia malayi Carboxylesterase family protein 0.0272 0.6605 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.7578 1
Echinococcus multilocularis carboxylesterase 5A 0.0272 0.6605 0.6605
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0011 0.0061 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0985 0.0985
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0057 0.0087
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0257 0.0257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0253 0.1081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0057 0.0087
Entamoeba histolytica hypothetical protein 0.0012 0.0091 0.5
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0091 0.5
Echinococcus granulosus chromobox protein 1 0.0072 0.1592 0.1592
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2775 0.4202
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0091 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0043 0.088 0.5254
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0178 0.058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0057 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0057 0.0087
Brugia malayi Carboxylesterase family protein 0.0046 0.0947 0.1434
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1251 0.1894
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0011 0.0061 0.0061
Echinococcus granulosus serotonin transporter 0.0062 0.1354 0.1354
Echinococcus granulosus cpg binding protein 0.003 0.0554 0.0554
Brugia malayi chromobox protein homolog 3 0.004 0.0803 0.1216
Schistosoma mansoni cpg binding protein 0.0029 0.0513 0.0513
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0011 0.0061 0.0093
Loa Loa (eye worm) solute carrier family 6 member 4 0.0062 0.1354 0.2051
Echinococcus granulosus sodium and chloride dependent glycine 0.0011 0.0061 0.0061
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.1354 0.2051
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0091 0.0138
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0091 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0057 0.0087
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0011 0.0061 0.5
Echinococcus granulosus Chromobox protein 3 0.0012 0.0091 0.0091
Echinococcus multilocularis GPCR, family 2 0.0018 0.0257 0.0257
Onchocerca volvulus 0.0032 0.0586 0.4074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0253 0.1081
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0011 0.0061 0.0061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0253 0.1081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0985 0.0985
Onchocerca volvulus 0.0046 0.0947 0.6861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0057 0.0087
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0947 0.5706
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Onchocerca volvulus 0.0046 0.0947 0.6861
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0057 0.0087
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0057 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0057 0.0087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0513 0.0777
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.3479 0.3871
Schistosoma mansoni hypothetical protein 0.004 0.0791 0.0791
Schistosoma mansoni hypothetical protein 0.0018 0.0257 0.0257
Echinococcus granulosus chromobox protein 2 0.0012 0.0091 0.0091
Loa Loa (eye worm) carboxylesterase 0.0272 0.6605 1
Echinococcus multilocularis serotonin transporter 0.0062 0.1354 0.1354
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0057 0.0057
Onchocerca volvulus 0.0011 0.0061 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2775 0.4202
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0132 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0057 0.0087
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0985 0.0985
Loa Loa (eye worm) norepinephrine transporter 0.0062 0.1354 0.2051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0253 0.1081
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0091 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0091 0.0091
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0011 0.0061 0.0061
Loa Loa (eye worm) acetylcholinesterase 1 0.0272 0.6605 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0057 0.0057
Loa Loa (eye worm) carboxylesterase 0.0046 0.0947 0.1434
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Brugia malayi hypothetical protein 0.0011 0.0061 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0985 0.0985
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0011 0.0061 0.0093
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0947 0.0947
Schistosoma mansoni hypothetical protein 0.0018 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Echinococcus granulosus FTZ F1 alpha 0.001 0.0057 0.0057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1251 0.1894
Brugia malayi SET domain containing protein 0.0012 0.0107 0.0161
Toxoplasma gondii hypothetical protein 0.005 0.1052 0.9064
Brugia malayi CXXC zinc finger family protein 0.0029 0.0513 0.0777
Trichomonas vaginalis chromobox protein, putative 0.0043 0.088 0.5254
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0257 0.0257
Brugia malayi hypothetical protein 0.0046 0.0947 0.1434
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0011 0.0061 0.0061
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0791 0.1197
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0057 0.0087
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0057 0.0087
Echinococcus multilocularis neuroligin 0.0046 0.0947 0.0947
Echinococcus multilocularis acetylcholinesterase 0.0272 0.6605 0.6605
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0947 0.0947
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0132 0.0132
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0132 0.0132
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0091 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0024
Schistosoma mansoni thyroid hormone receptor 0.001 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0107 0.0107
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0057 0.0057
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Schistosoma mansoni hypothetical protein 0.0018 0.0257 0.0257
Schistosoma mansoni acetylcholinesterase 0.0046 0.0947 0.0947
Brugia malayi Carboxylesterase family protein 0.0046 0.0947 0.1434
Loa Loa (eye worm) hypothetical protein 0.0062 0.1354 0.2051
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0057 0.0057
Echinococcus granulosus sodium and chloride dependent glycine 0.0011 0.0061 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Loa Loa (eye worm) hypothetical protein 0.0062 0.1354 0.2051
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0272 0.6605 0.6605
Schistosoma mansoni chromobox protein 0.0012 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0057 0.0057
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0091 0.0138
Echinococcus granulosus Chromo domain 0.0012 0.0091 0.0091
Onchocerca volvulus 0.0046 0.0947 0.6861
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0091 0.0138
Schistosoma mansoni hypothetical protein 0.0012 0.0091 0.0091
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0257 0.0257
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.7578 1
Echinococcus granulosus chromobox protein 1 0.0072 0.1592 0.1592
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0509 0.2789
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1592 1
Onchocerca volvulus 0.0011 0.0061 0.0031
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0803 0.575
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0947 0.0947
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0253 0.1081
Loa Loa (eye worm) carboxylesterase 0.0046 0.0947 0.1434
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0947 0.0947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0985 0.0985
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0057 0.0087
Schistosoma mansoni chromobox protein 0.0072 0.1592 0.1592
Onchocerca volvulus 0.0029 0.0513 0.3516
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0253 0.1081
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.004 0.0803 0.1216
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0057 0.0057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0057 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0166 0.0501
Echinococcus multilocularis Chromo domain 0.0012 0.0091 0.0091
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.3479 0.3871
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0011 0.0061 0.0093
Onchocerca volvulus 0.0012 0.0091 0.0258
Entamoeba histolytica hypothetical protein 0.0012 0.0091 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Echinococcus granulosus acetylcholinesterase 0.0272 0.6605 0.6605
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1592 1
Echinococcus granulosus acetylcholinesterase 0.0272 0.6605 0.6605
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0019 0.0028
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0091 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0257 0.0389
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0091 0.5
Echinococcus multilocularis sodium and chloride dependent glycine 0.0011 0.0061 0.0061
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.7578 1
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0947 0.0947
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0091 0.0269
Loa Loa (eye worm) hypothetical protein 0.0058 0.1251 0.1894
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0091 0.0091
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0803 0.4746
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0257 0.0389
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0257 0.0389
Brugia malayi steroid hormone receptor 0.001 0.0057 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0057 0.0087
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0091 0.0269
Schistosoma mansoni hypothetical protein 0.0408 1 1
Echinococcus multilocularis cpg binding protein 0.003 0.0554 0.0554
Brugia malayi ecdysteroid receptor 0.001 0.0057 0.0087
Onchocerca volvulus 0.0011 0.0061 0.0031
Echinococcus multilocularis acetylcholinesterase 0.0272 0.6605 0.6605
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.004 0.0791 0.1197
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.0554
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0253 0.1081
Schistosoma mansoni chromobox protein 0.0072 0.1592 0.1592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0057 0.0087
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.3895 1
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0091 0.0138
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0011 0.0061 0.0093
Schistosoma mansoni sodium/chloride dependent transporter 0.0011 0.0061 0.0061
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0803 0.4746
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0057 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0057 0.0087
Onchocerca volvulus 0.0012 0.0107 0.0378
Schistosoma mansoni hypothetical protein 0.0018 0.0257 0.0257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0985 0.0985
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0057 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.0011 0.0061 0.0061
Brugia malayi Protein cec-1. 0.0012 0.0091 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0057 0.0087
Echinococcus multilocularis chromobox protein 1 0.0072 0.1592 0.1592
Brugia malayi hypothetical protein 0.0012 0.0091 0.0138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0586 0.0887
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0091 1
Brugia malayi Heterochromatin protein 1 0.0072 0.1592 0.241
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0947 0.5706
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0057 0.0057
Brugia malayi CHD4 protein 0.0013 0.0132 0.0199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0985 0.1491
Schistosoma mansoni sodium-dependent amino acid transporter 0.0011 0.0061 0.0061
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0272 0.6605 1
Echinococcus granulosus neuroligin 0.0046 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Brugia malayi MH2 domain containing protein 0.0119 0.2775 0.4202
Schistosoma mansoni coup transcription factor 0.001 0.0057 0.0057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1251 0.1894
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0011 0.0061 0.0061
Treponema pallidum sodium- and chloride- dependent transporter 0.0062 0.1354 0.5
Schistosoma mansoni cpg binding protein 0.003 0.0554 0.0554
Brugia malayi nuclear receptor NHR-88 0.001 0.0057 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Echinococcus granulosus GPCR family 2 0.0018 0.0257 0.0257
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0011 0.0061 0.0061
Brugia malayi Carboxylesterase family protein 0.0272 0.6605 1
Schistosoma mansoni gliotactin 0.0046 0.0947 0.0947
Schistosoma mansoni chromobox protein 0.0012 0.0091 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0093
Loa Loa (eye worm) helicase 0.0012 0.0091 0.0138
Schistosoma mansoni thyroid hormone receptor 0.001 0.0057 0.0057
Brugia malayi Carboxylesterase family protein 0.0046 0.0947 0.1434
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0057 0.0087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1154 1
Echinococcus granulosus carboxylesterase 5A 0.0272 0.6605 0.6605
Mycobacterium ulcerans hypothetical protein 0.0164 0.3895 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0011 0.0061 0.0061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0178 0.058
Loa Loa (eye worm) hypothetical protein 0.0062 0.1354 0.2051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0057 0.0057
Echinococcus multilocularis chromobox protein 2 0.0012 0.0091 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0253 0.1081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0057 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.0062 0.1354 0.1354
Brugia malayi Carboxylesterase family protein 0.0046 0.0947 0.1434
Schistosoma mansoni nuclear hormone receptor 0.001 0.0057 0.0057
Echinococcus multilocularis sodium and chloride dependent glycine 0.0011 0.0061 0.0061
Echinococcus multilocularis chromobox protein 1 0.0072 0.1592 0.1592
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0132 0.0199
Onchocerca volvulus 0.0046 0.0947 0.6861
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0947 0.0947
Brugia malayi nuclear hormone receptor 0.001 0.0057 0.0087
Entamoeba histolytica hypothetical protein 0.0012 0.0091 0.5
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0091 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0257 0.0389
Loa Loa (eye worm) hypothetical protein 0.0046 0.0947 0.1434
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0057 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0012 0.0091 0.0138
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.1592 0.241
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0509 0.2789
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0057 0.0057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1317 0.1317
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0057 0.0087
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0947 0.0947
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0057 0.0057
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0057 0.0057
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0947 0.0947
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0985 0.1491
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0062 0.1354 0.1354
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.7578 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0011 0.0061 0.0093
Onchocerca volvulus 0.0046 0.0947 0.6861
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0057 0.0057
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0011 0.0061 0.0061

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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