Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.098 | 0.0478 | 0.0145 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0742 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.5713 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0742 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.163 | 0.1786 | 0.3117 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0742 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.3066 | 0.4675 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.5713 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.163 | 0.1786 | 0.3117 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0742 | 0 | 0.5 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.3066 | 0.4675 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0742 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.5713 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.3066 | 0.4675 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5713 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1647 | 0.1821 | 0.32 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5713 | 1 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1647 | 0.1821 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.1647 | 0.1821 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1647 | 0.1821 | 0.3299 |
Echinococcus multilocularis | insulin receptor | 0.098 | 0.0478 | 0.0145 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.3066 | 0.4675 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.163 | 0.1786 | 0.3117 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.5713 | 1 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.3066 | 0.4675 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.5713 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.1647 | 0.1821 | 0.32 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.