Detailed information for compound 888014

Basic information

Technical information
  • TDR Targets ID: 888014
  • Name: N-(2,4-dimethoxyphenyl)-5-fluoro-2-methylbenz enesulfonamide
  • MW: 325.355 | Formula: C15H16FNO4S
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1NS(=O)(=O)c1cc(F)ccc1C
  • InChi: 1S/C15H16FNO4S/c1-10-4-5-11(16)8-15(10)22(18,19)17-13-7-6-12(20-2)9-14(13)21-3/h4-9,17H,1-3H3
  • InChiKey: IGRNKVGTFCQEDV-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(2,4-dimethoxyphenyl)-5-fluoro-2-methyl-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Brugia malayi MH2 domain containing protein 0.0116 0.0645 1
Leishmania major p-glycoprotein 0.0058 0.0282 1
Trypanosoma cruzi multidrug resistance protein E, putative 0.0018 0.0038 0.521
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.4202
Loa Loa (eye worm) multidrug resistance protein 3 0.0058 0.0282 0.4374
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0585
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0018 0.0038 0.0038
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0058 0.0282 0.2981
Echinococcus granulosus ATP binding cassette sub family B 0.0017 0.0034 0.0358
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.1628 1 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0018 0.0038 0.0585
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0058 0.0282 1
Echinococcus multilocularis multidrug resistance protein 1 0.004 0.0175 0.1846
Giardia lamblia ABC transporter, putative 0.0018 0.0038 1
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0056 0.0597
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0058 0.0282 0.2981
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0058 0.0282 0.5
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0018 0.0038 0.521
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0038 0.0769
Echinococcus multilocularis multidrug resistance associated protein 1 0.0018 0.0038 0.0399
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0018 0.0038 0.5
Loa Loa (eye worm) calpain family protein 1 0.0056 0.0271 0.4202
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Trichomonas vaginalis abcb9, putative 0.0058 0.0282 1
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0018 0.0038 0.521
Loa Loa (eye worm) ABC transporter 0.0018 0.0038 0.0585
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Brugia malayi multidrug resistance protein 3 0.0058 0.0282 0.4374
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0018 0.0038 0.0769
Brugia malayi ABC transporter family protein 0.0018 0.0038 0.0585
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0287 0.3029
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0056 1
Brugia malayi ABC transporter 0.0018 0.0038 0.0585
Echinococcus multilocularis ATP binding cassette sub family B 0.0018 0.0038 0.0399
Brugia malayi calpain 5 0.0015 0.0017 0.0269
Schistosoma mansoni multidrug resistance protein 0.0017 0.0034 0.0358
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0058 0.0282 0.4374
Entamoeba histolytica P-glyco protein 6, putative 0.0058 0.0282 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0018 0.0038 0.521
Schistosoma mansoni calpain (C02 family) 0.0021 0.0056 0.0597
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0018 0.0038 0.0038
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0056 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 0.1476
Giardia lamblia Multidrug resistance-associated protein 1 0.0018 0.0038 1
Trichomonas vaginalis abcb9, putative 0.0058 0.0282 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0645 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0058 0.0282 0.2981
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0058 0.0282 0.2981
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Brugia malayi ABC transporter family protein 0.0018 0.0038 0.0585
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.2793
Entamoeba histolytica P-glycoprotein-5 0.0058 0.0282 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0058 0.0282 0.0245
Echinococcus granulosus multidrug resistance protein 1 0.004 0.0175 0.1846
Trichomonas vaginalis ABC transporter, putative 0.0058 0.0282 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0058 0.0282 1
Trichomonas vaginalis ABC transporter, putative 0.0058 0.0282 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0017 0.0034 0.0623
Schistosoma mansoni multidrug resistance protein 0.0058 0.0282 0.2981
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0018 0.0038 0.521
Entamoeba histolytica P-glycoprotein-2 0.0058 0.0282 1
Schistosoma mansoni hypothetical protein 0.0165 0.0947 1
Brugia malayi calpain family protein 1 0.0056 0.0271 0.4202
Brugia malayi ABC transporter transmembrane region family protein 0.0018 0.0038 0.0585
Loa Loa (eye worm) hypothetical protein 0.0058 0.0282 0.4374
Brugia malayi calpain family protein 1 0.0056 0.0271 0.4202
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0645 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0018 0.0038 0.0038
Echinococcus multilocularis hypothetical protein 0.0021 0.0056 0.0597
Loa Loa (eye worm) ABC transporter 0.0018 0.0038 0.0585
Schistosoma mansoni multidrug resistance protein 0.0058 0.0282 0.2981
Echinococcus multilocularis 0.0018 0.0038 0.0399
Echinococcus granulosus multidrug resistance associated protein 7 0.0018 0.0038 0.0399
Giardia lamblia MRP-like ABC transporter 0.0018 0.0038 1
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0018 0.0038 0.0769
Echinococcus granulosus calpain 0.0021 0.0056 0.0597
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.004 0.0175 0.5674
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0525
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0056 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0038 0.0769
Brugia malayi ABC transporter transmembrane region family protein 0.0018 0.0038 0.0585
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.2187
Echinococcus multilocularis multidrug resistance protein 1 0.0058 0.0282 0.2981
Loa Loa (eye worm) hypothetical protein 0.0057 0.0278 0.4314
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0018 0.0038 0.0769
Loa Loa (eye worm) calpain 0.0021 0.0056 0.0875
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0018 0.0038 0.521
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.018 0.1904
Echinococcus granulosus multidrug resistance protein 1 0.0058 0.0282 0.2981
Brugia malayi ABC transporter 0.0017 0.0034 0.0525
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0287 0.3029
Echinococcus multilocularis ATP binding cassette sub family B 0.0018 0.0038 0.0399
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0056 0.0597
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Brugia malayi multidrug resistance related protein 1 0.0018 0.0038 0.0585
Loa Loa (eye worm) hypothetical protein 0.0058 0.0282 0.4374
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0058 0.0282 0.2981
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0018 0.0038 0.0769
Leishmania major pentamidine resistance protein 1 0.0018 0.0038 0.0769
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Onchocerca volvulus 0.0035 0.0141 0.5001
Echinococcus multilocularis ATP binding cassette sub family B 0.0018 0.0038 0.0399
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0056 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0018 0.0038 0.0769
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0058 0.0282 1
Schistosoma mansoni smdr2 0.0058 0.0282 0.2981
Brugia malayi ABC transporter family protein 0.0058 0.0282 0.4374
Echinococcus multilocularis ATP binding cassette sub family B 0.0018 0.0038 0.0399
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0058 0.0282 1
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.0034 0.0525
Schistosoma mansoni multidrug resistance protein 0.0018 0.0038 0.0399
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0058 0.0282 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0057 0.0278 0.294
Echinococcus multilocularis geminin 0.0165 0.0947 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0525
Echinococcus granulosus ATP binding cassette sub family B 0.0018 0.0038 0.0399
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0018 0.0038 0.521
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0058 0.0282 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0038 0.0769
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0018 0.0038 0.521
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0058 0.0282 0.2981
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0058 0.0282 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0018 0.0038 0.0038
Echinococcus granulosus multidrug resistance associated protein 1 0.0018 0.0038 0.0399
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0018 0.0038 0.0769
Loa Loa (eye worm) calpain family protein 1 0.0041 0.018 0.2793
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0271 0.2864
Echinococcus granulosus calpain A 0.0058 0.0287 0.3029
Leishmania major ABC-thiol transporter 0.0018 0.0038 0.0769
Trypanosoma brucei multidrug resistance protein E 0.0018 0.0038 0.521
Schistosoma mansoni multidrug resistance protein 0.0018 0.0038 0.0399
Schistosoma mansoni smdr1 0.0018 0.0038 0.0399
Trichomonas vaginalis abcb9, putative 0.0058 0.0282 1
Brugia malayi ABC transporter family protein 0.0018 0.0038 0.0585
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0287 0.3029
Echinococcus granulosus geminin 0.0165 0.0947 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0058 0.0282 1
Trichomonas vaginalis taga, putative 0.0058 0.0282 1
Echinococcus granulosus multidrug resistance protein 1 0.0058 0.0282 0.2981
Plasmodium vivax calpain, putative 0.0021 0.0056 0.0766
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0585
Brugia malayi hypothetical protein 0.0018 0.0038 0.0585
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 0.1476
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0017 0.0034 0.0358
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0018 0.0038 0.5
Entamoeba histolytica P-glycoprotein-2 0.0058 0.0282 1
Echinococcus granulosus calpain 5 0.0021 0.0056 0.0597
Leishmania major p-glycoprotein e 0.0018 0.0038 0.0769
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 0.1476
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0056 0.0597
Echinococcus multilocularis multidrug resistance protein 1 0.0058 0.0282 0.2981
Echinococcus multilocularis calpain 0.0021 0.0056 0.0597
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0287 0.3029
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0058 0.0282 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0018 0.0038 0.0769
Entamoeba histolytica P-glycoprotein 6, putative 0.0018 0.0038 0.0769
Entamoeba histolytica P-glycoprotein-1 0.0058 0.0282 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0018 0.0038 0.0585
Entamoeba histolytica multidrug resistance protein, putative 0.0018 0.0038 0.0769
Schistosoma mansoni multidrug resistance protein 0.0018 0.0038 0.0399
Entamoeba histolytica P-glycoprotein-2, putative 0.0058 0.0282 1
Trichomonas vaginalis ABC transporter, putative 0.0058 0.0282 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0018 0.0038 0.0399
Schistosoma mansoni multidrug resistance protein 0.0018 0.0038 0.0399
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0018 0.0038 0.0769
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0058 0.0282 1
Schistosoma mansoni hypothetical protein 0.0165 0.0947 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0056 0.0597
Trypanosoma brucei p-glycoprotein 0.0018 0.0038 0.521
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.3597
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0058 0.0282 0.2981
Echinococcus granulosus multidrug resistance protein 1 0.004 0.0175 0.1846
Entamoeba histolytica ATP-binding cassette protein, putative 0.0018 0.0038 0.0769
Giardia lamblia Multidrug resistance-associated protein 1 0.0018 0.0038 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0058 0.0282 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0017 0.0034 0.0623
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0058 0.0282 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0057 0.0278 0.294
Schistosoma mansoni multidrug resistance protein 0.0058 0.0282 0.2981
Echinococcus granulosus ATP binding cassette sub family B 0.0018 0.0038 0.0399
Trypanosoma brucei antigen, putative 0.0021 0.0056 1
Schistosoma mansoni multidrug resistance protein 0.0018 0.0038 0.0399
Loa Loa (eye worm) hypothetical protein 0.0018 0.0038 0.0585
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0056 1
Loa Loa (eye worm) ABC transporter 0.0018 0.0038 0.0585
Echinococcus multilocularis calpain 5 0.0021 0.0056 0.0597
Brugia malayi P-glycoprotein-like protein 0.0018 0.0038 0.0585
Onchocerca volvulus 0.0058 0.0282 1
Echinococcus multilocularis calpain A 0.0058 0.0287 0.3029
Trichomonas vaginalis ABC transporter, putative 0.0058 0.0282 1
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0056 1
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0056 0.0597
Echinococcus granulosus calpain A 0.0021 0.0056 0.0597
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0058 0.0282 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0018 0.0038 0.0399
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 1
Loa Loa (eye worm) calpain 5 0.0015 0.0017 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0058 0.0282 0.2981
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0018 0.0038 0.0038
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0056 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0058 0.0282 0.2981
Entamoeba histolytica ABC transporter, putative 0.0018 0.0038 0.0769
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0018 0.0038 0.521
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0056 0.0597
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0056 1
Brugia malayi calpain 7 0.0021 0.0056 0.0875
Plasmodium falciparum multidrug resistance protein 1 0.0058 0.0282 1
Entamoeba histolytica hypothetical protein 0.0018 0.0038 0.0769
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 1
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0056 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0058 0.0282 1
Echinococcus granulosus multidrug resistance protein 1 0.0058 0.0282 0.2981
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0056 1
Mycobacterium ulcerans proteasome PrcA 0.1628 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0056 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0018 0.0038 0.0156

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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