Detailed information for compound 888015

Basic information

Technical information
  • TDR Targets ID: 888015
  • Name: 3-(3,4-dimethylphenyl)-1-[2-(4-ethoxyphenyl)e thyl]thiourea
  • MW: 328.472 | Formula: C19H24N2OS
  • H donors: 2 H acceptors: 0 LogP: 4.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)CCNC(=S)Nc1ccc(c(c1)C)C
  • InChi: 1S/C19H24N2OS/c1-4-22-18-9-6-16(7-10-18)11-12-20-19(23)21-17-8-5-14(2)15(3)13-17/h5-10,13H,4,11-12H2,1-3H3,(H2,20,21,23)
  • InChiKey: BLSLPEGPLRHGDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_008989

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0552 0.7641
Plasmodium falciparum plasmepsin III 0.0023 0.0004 0.0019
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0021 0.0059
Echinococcus granulosus cathepsin b 0.0133 0.1268 0.3623
Brugia malayi Cytochrome P450 family protein 0.0039 0.0197 0.0293
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0068 0.0519 0.1916
Plasmodium falciparum importin beta, putative 0.003 0.0091 0.05
Trypanosoma cruzi kinesin, putative 0.0071 0.0561 0.2072
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0914 0.1361
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0026 0.0142
Trichomonas vaginalis ABC transporter, putative 0.0053 0.0357 0.4938
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0044 0.025 0.0923
Echinococcus granulosus importin subunit beta 1 0.003 0.0091 0.026
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0057 0.0209
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0254 0.0378
Brugia malayi hypothetical protein 0.0025 0.0026 0.0039
Trypanosoma brucei oligopeptidase b 0.0103 0.0924 0.3412
Schistosoma mansoni calpain C (C02 family) 0.0102 0.0912 0.2657
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0044 0.025 0.0729
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0057 0.0084
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0044 0.025 0.3465
Toxoplasma gondii prolyl endopeptidase 0.0259 0.271 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0053 0.0357 0.0401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0295 0.044
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0096 0.1335
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0023 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Plasmodium falciparum peptidase, putative 0.0027 0.0057 0.0311
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0027 0.0057 0.0209
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0053 0.0357 0.0401
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0552 0.0202
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0004 0.0019
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0232 0.2399 0.2118
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0567 0.0845
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Trypanosoma cruzi 20S proteasome subunit 0.0044 0.025 0.0923
Entamoeba histolytica hypothetical protein 0.0025 0.0026 0.0358
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.0357 0.4938
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0004 0.0019
Trypanosoma brucei proteasome beta 6 subunit 0.0068 0.0519 0.1916
Brugia malayi hypothetical protein 0.0102 0.0914 0.1361
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0068 0.0519 0.1916
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0044 0.025 0.0923
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0053 0.0357 0.1316
Onchocerca volvulus 0.0071 0.0552 0.2026
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0053 0.0357 0.0401
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0068 0.0519 0.1916
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.1268 0.3694
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0057 0.0785
Brugia malayi calpain 7 0.0102 0.0912 0.1358
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0031 0.0096 0.0356
Echinococcus multilocularis calpain A 0.0286 0.3016 0.3395
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0085 0.0722 1
Leishmania major calpain family cysteine protease-like protein 0.0031 0.0096 0.0356
Plasmodium falciparum plasmepsin I 0.0023 0.0004 0.0019
Schistosoma mansoni ets-related 0.0218 0.224 0.6526
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0096 0.1335
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.074
Trypanosoma brucei Calpain-like protein CALP1.3 0.0031 0.0096 0.0356
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0286 0.3014 0.861
Brugia malayi MH1 domain containing protein 0.0024 0.0021 0.0031
Echinococcus granulosus snurportin 1 0.0323 0.3433 0.9806
Loa Loa (eye worm) hypothetical protein 0.0071 0.0552 0.0822
Trypanosoma brucei kinesin, putative 0.0071 0.0561 0.2072
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0053 0.0357 0.0531
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Loa Loa (eye worm) multidrug resistance protein 3 0.0053 0.0357 0.0531
Loa Loa (eye worm) hypothetical protein 0.0071 0.0552 0.0822
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Echinococcus multilocularis tumor protein p63 0.0329 0.35 0.3939
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0021 0.006
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0096 0.0356
Brugia malayi hypothetical protein 0.0023 0.0004 0.0005
Brugia malayi cathepsin B-like cysteine proteinase 0.0133 0.1268 0.1888
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0044 0.0248 0.0916
Onchocerca volvulus 0.0168 0.1671 0.6163
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0085 0.0722 0.2665
Onchocerca volvulus Peroxidasin homolog 0.0102 0.0914 0.3366
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0026 0.0142
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0057 0.0785
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0103 0.0924 0.0589
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0053 0.035 0.1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0053 0.0357 0.1019
Trypanosoma brucei Calpain-like protein 2 0.0031 0.0096 0.0356
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0914 0.1361
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0004 0.0019
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0552 0.1576
Trypanosoma brucei calpain-like protein, putative 0.0102 0.0912 0.3366
Loa Loa (eye worm) calpain 5 0.0071 0.0561 0.0836
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0912 0.3366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0254 0.0726
Trypanosoma cruzi oligopeptidase b 0.0103 0.0924 0.3412
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0044 0.025 0.1372
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0286 0.3014 0.878
Plasmodium falciparum plasmepsin II 0.0023 0.0004 0.0019
Echinococcus multilocularis calpain family protein 1, d 0.0199 0.2022 0.2275
Echinococcus multilocularis cathepsin b 0.0133 0.1268 0.1427
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0197 0.0727
Echinococcus granulosus calpain 0.0102 0.0912 0.2606
Trichomonas vaginalis esterase, putative 0.0071 0.0552 0.7641
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0027 0.0057 0.0209
Mycobacterium ulcerans proteasome PrcA 0.0897 1 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0096 0.0356
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0096 0.1335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.074
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0026 0.0096
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Echinococcus granulosus Smad4 0.0024 0.0021 0.0059
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0031 0.0096 0.0356
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0053 0.0357 0.1316
Mycobacterium tuberculosis Probable peptidase 0.0103 0.0924 0.0589
Brugia malayi calpain 5 0.0071 0.0561 0.0836
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.027 0.2837 0.8266
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0914 0.1361
Leishmania major importin beta-1 subunit, putative 0.0025 0.0026 0.0095
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0023 0.0004 0.0049
Echinococcus multilocularis ATP binding cassette sub family B 0.0053 0.035 0.0394
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Mycobacterium tuberculosis Conserved protein 0.0071 0.0552 0.0202
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0026 0.0096
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0254 0.074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0005
Leishmania major hypothetical protein, unknown function 0.0031 0.0096 0.0356
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0026 0.0358
Echinococcus multilocularis Smad4 0.0024 0.0021 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0254 0.0378
Trichomonas vaginalis calpain, putative 0.0031 0.0096 0.1335
Trypanosoma brucei prolyl oligopeptidase, putative 0.0103 0.0924 0.3412
Echinococcus multilocularis calpain 0.0102 0.0912 0.1026
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0031 0.0096 0.0356
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0102 0.0912 0.3366
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0005
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0091 0.0337
Loa Loa (eye worm) hypothetical protein 0.0259 0.271 0.4035
Leishmania major proteasome beta 5 subunit, putative 0.0085 0.0722 0.2665
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Echinococcus multilocularis smad 0.0024 0.0021 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0666 0.0992
Echinococcus granulosus Dipeptidyl peptidase 9 0.0027 0.0057 0.0162
Toxoplasma gondii hypothetical protein 0.0027 0.0057 0.0209
Toxoplasma gondii hypothetical protein 0.0031 0.0096 0.0356
Entamoeba histolytica P-glycoprotein-5 0.0053 0.0357 0.4938
Echinococcus granulosus prolyl endopeptidase 0.0259 0.271 0.7741
Brugia malayi beta-lactamase family protein 0.0071 0.0552 0.0822
Schistosoma mansoni multidrug resistance protein 0.0053 0.0357 0.1039
Plasmodium vivax plasmepsin IV, putative 0.0023 0.0004 0.0019
Giardia lamblia Proteasome subunit beta type 1 0.0068 0.0519 0.7189
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Schistosoma mansoni smad1 5 8 and 0.0024 0.0021 0.006
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.0357 0.4938
Loa Loa (eye worm) proteasome subunit beta type 1 0.0068 0.0519 0.0773
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0897 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0552 0.2036
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Loa Loa (eye worm) calpain 0.0102 0.0912 0.1358
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.0357 0.4938
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0068 0.0519 0.1916
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0053 0.0357 0.0401
Brugia malayi Ets-domain containing protein 0.0072 0.0567 0.0845
Trichomonas vaginalis ABC transporter, putative 0.0053 0.0357 0.4938
Giardia lamblia Proteasome subunit beta type 2 0.0044 0.025 0.3465
Onchocerca volvulus 0.0071 0.0552 0.2026
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Onchocerca volvulus Peroxidasin homolog 0.0102 0.0914 0.3366
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0259 0.271 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0027 0.0057 0.0165
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0085 0.0722 0.0379
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Plasmodium vivax calpain, putative 0.0102 0.0912 0.5002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.045 0.4895 0.4706
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0103 0.0924 0.3412
Mycobacterium ulcerans beta-lactamase 0.0071 0.0552 0.0362
Toxoplasma gondii aspartyl protease ASP3 0.0182 0.1823 0.673
Echinococcus multilocularis snurportin 1 0.0323 0.3433 0.3863
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0552 0.0362
Echinococcus granulosus proteasome prosome macropain 0.0085 0.0722 0.2063
Trypanosoma cruzi oligopeptidase b 0.0103 0.0924 0.3412
Echinococcus granulosus tumor protein p63 0.0329 0.35 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0096 0.1335
Loa Loa (eye worm) calpain family protein 1 0.027 0.2837 0.4225
Echinococcus granulosus peroxidasin 0.0102 0.0914 0.2612
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0057 0.0785
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0057 0.0209
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0027 0.0057 0.0165
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0027 0.0057 0.0064
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0085 0.0722 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.0357 0.4938
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0057 0.0209
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.8886 1
Plasmodium falciparum proteasome subunit beta type-5 0.0085 0.0722 0.396
Trypanosoma brucei hypothetical protein 0.0031 0.0096 0.0356
Schistosoma mansoni peroxidasin 0.0102 0.0914 0.2664
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0053 0.0357 0.1019
Brugia malayi Cytochrome P450 family protein 0.0081 0.0666 0.0992
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0021 0.0023
Trypanosoma brucei Calpain-like protein 1.1 0.0031 0.0096 0.0356
Onchocerca volvulus Peroxidase homolog 0.0102 0.0914 0.3366
Trichomonas vaginalis abcb9, putative 0.0053 0.0357 0.4938
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.1268 0.3694
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0103 0.0924 0.0742
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0103 0.0924 0.3412
Schistosoma mansoni Smad4 0.0024 0.0021 0.006
Loa Loa (eye worm) beta-lactamase 0.0071 0.0552 0.0822
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0026 0.0095
Schistosoma mansoni calpain-2 (C02 family) 0.0031 0.0096 0.0281
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Onchocerca volvulus 0.0053 0.0357 0.1305
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0254 0.0726
Onchocerca volvulus 0.0102 0.0914 0.3366
Entamoeba histolytica protein kinase, putative 0.0071 0.0561 0.7776
Mycobacterium tuberculosis Conserved protein 0.0071 0.0552 0.0202
Schistosoma mansoni smdr2 0.0053 0.0357 0.1039
Schistosoma mansoni peroxidasin 0.0102 0.0914 0.2664
Loa Loa (eye worm) calpain D 0.0031 0.0096 0.0144
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Schistosoma mansoni calpain-7 (C02 family) 0.0102 0.0912 0.2657
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Leishmania major cytochrome p450-like protein 0.0039 0.0197 0.0727
Schistosoma mansoni cathepsin D (A01 family) 0.0208 0.2127 0.6197
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0133 0.1268 0.3694
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0914 0.1361
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0552 0.2036
Loa Loa (eye worm) blistered cuticle protein 3 0.0102 0.0914 0.1361
Echinococcus granulosus calpain A 0.0102 0.0912 0.2606
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Brugia malayi Peroxidasin 0.0102 0.0914 0.1361
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0057 0.0084
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0057 0.0785
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0552 0.0202
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.1268 0.3694
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0057 0.0084
Entamoeba histolytica P-glycoprotein-2 0.0053 0.0357 0.4938
Echinococcus multilocularis multidrug resistance protein 1 0.0037 0.0172 0.0194
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0021 0.0059
Leishmania major oligopeptidase b 0.0103 0.0924 0.3412
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0096 0.0356
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0914 0.1361
Brugia malayi calpain 5 0.0031 0.0096 0.0144
Entamoeba histolytica P-glycoprotein-1 0.0053 0.0357 0.4938
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0552 0.7641
Loa Loa (eye worm) hypothetical protein 0.003 0.0091 0.0136
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.3433 0.5111
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0912 0.3366
Echinococcus granulosus calpain 7 C02 family 0.0102 0.0912 0.2606
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0027 0.0057 0.0209
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0197 0.0293
Plasmodium vivax aspartyl protease, putative 0.0182 0.1823 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0085 0.0722 0.018
Trichomonas vaginalis taga, putative 0.0053 0.0357 0.4938
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0552 0.7641
Brugia malayi MH2 domain containing protein 0.0353 0.3778 0.5626
Entamoeba histolytica calpain family cysteine protease, putative 0.0031 0.0096 0.1335
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Brugia malayi Ets-domain containing protein 0.0072 0.0567 0.0845
Schistosoma mansoni smad1 5 8 and 0.0024 0.0021 0.006
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0103 0.0924 0.0394
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0039
Toxoplasma gondii aspartyl protease ASP1 0.0023 0.0004 0.0013
Trichomonas vaginalis calpain, putative 0.0031 0.0096 0.1335
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0552 0.7641
Brugia malayi aspartic protease BmAsp-1, identical 0.0023 0.0004 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Schistosoma mansoni calpain (C02 family) 0.0102 0.0912 0.2657
Loa Loa (eye worm) proteasome subunit beta type 2 0.0044 0.025 0.0373
Loa Loa (eye worm) hypothetical protein 0.0053 0.035 0.0521
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Loa Loa (eye worm) calpain family protein 1 0.0199 0.2022 0.3011
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0552 0.7641
Brugia malayi Importin beta-1 subunit 0.003 0.0091 0.0136
Trypanosoma cruzi kinesin, putative 0.0071 0.0561 0.2072
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Brugia malayi calpain family protein 1 0.027 0.2837 0.4225
Brugia malayi proteasome subunit beta type 2 0.0044 0.025 0.0373
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Echinococcus multilocularis peroxidasin 0.0102 0.0914 0.1029
Brugia malayi calpain D 0.0031 0.0096 0.0144
Plasmodium vivax aspartyl protease, putative 0.0023 0.0004 0.0019
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0053 0.0357 0.1316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0254 0.0286
Echinococcus granulosus multidrug resistance protein 1 0.0037 0.0172 0.0492
Brugia malayi beta-lactamase 0.0071 0.0552 0.0822
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0044 0.0248 0.0916
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Toxoplasma gondii ABC1 family protein 0.0071 0.0552 0.2036
Schistosoma mansoni multidrug resistance protein 0.0053 0.0357 0.1039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.0357 0.4938
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0552 0.0202
Onchocerca volvulus Peroxidase homolog 0.0102 0.0914 0.3366
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trypanosoma brucei calpain-like protein, putative 0.0102 0.0912 0.3366
Plasmodium falciparum plasmepsin X 0.0182 0.1823 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0552 0.0202
Entamoeba histolytica P-glycoprotein 5, putative 0.0053 0.0357 0.4938
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0021 0.0031
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0004 0.0005
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0023 0.0004 0.001
Trichomonas vaginalis ABC transporter, putative 0.0053 0.0357 0.4938
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0912 0.3366
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0259 0.271 0.7894
Leishmania major hypothetical protein, conserved 0.0071 0.0552 0.2036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0552 0.0362
Plasmodium vivax importin-beta 2, putative 0.003 0.0091 0.05
Echinococcus multilocularis proteasome (prosome, macropain) 0.0085 0.0722 0.0813
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Giardia lamblia Cathepsin B precursor 0.0044 0.0248 0.3437
Trypanosoma brucei cysteine peptidase C (CPC) 0.0044 0.0248 0.0916
Loa Loa (eye worm) hypothetical protein 0.0071 0.0552 0.0822
Brugia malayi hypothetical protein 0.0023 0.0004 0.0005
Brugia malayi MH2 domain containing protein 0.0024 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0168 0.1671 0.2489
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Schistosoma mansoni calpain-7 (C02 family) 0.0102 0.0912 0.2657
Toxoplasma gondii cathepsin B 0.0044 0.0248 0.0916
Schistosoma mansoni smad1 5 8 and 0.0024 0.0021 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0552 0.1607
Brugia malayi calpain family protein 1 0.027 0.2837 0.4225
Trypanosoma brucei calpain, putative 0.0031 0.0096 0.0356
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Echinococcus multilocularis geminin 0.0165 0.1635 0.184
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0044 0.025 0.0923
Plasmodium vivax plasmepsin V, putative 0.0023 0.0004 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0021 0.0031
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0053 0.0357 0.1019
Schistosoma mansoni smad 0.0024 0.0021 0.006
Entamoeba histolytica P-glyco protein 6, putative 0.0053 0.0357 0.4938
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0027 0.0057 0.0209
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Onchocerca volvulus Chorion peroxidase homolog 0.0102 0.0914 0.3366
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0133 0.1268 0.468
Entamoeba histolytica P-glycoprotein-2, putative 0.0053 0.0357 0.4938
Plasmodium vivax multidrug resistance protein 1, putative 0.0053 0.0357 0.1955
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Leishmania major kinesin, putative 0.0071 0.0561 0.2072
Brugia malayi Angiotensin-converting enzyme family protein 0.061 0.6715 1
Brugia malayi Fli-1 protein 0.0218 0.224 0.3336
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0552 0.3026
Brugia malayi RNA, U transporter 1 0.0086 0.0728 0.1084
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0057 0.0785
Trypanosoma brucei calpain-like protein, putative 0.0102 0.0912 0.3366
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0567 0.1621
Trichomonas vaginalis abcb9, putative 0.0053 0.0357 0.4938
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0027 0.0057 0.0196
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0053 0.0357 0.4938
Schistosoma mansoni importin beta-1 0.003 0.0091 0.0266
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0914 0.1361
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0044 0.025 0.3465
Brugia malayi Smad1 0.0024 0.0021 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0353 0.3778 0.5626
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Brugia malayi multidrug resistance protein 3 0.0053 0.0357 0.0531
Loa Loa (eye worm) hypothetical protein 0.0199 0.2022 0.3011
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.0357 0.1019
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0068 0.0519 0.7189
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0552 0.0822
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0102 0.0912 0.3366
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0103 0.0924 0.3412
Schistosoma mansoni cathepsin D (A01 family) 0.0208 0.2127 0.6197
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0552 0.0202
Plasmodium vivax proteasome subunit beta type-2, putative 0.0044 0.025 0.1372
Schistosoma mansoni hypothetical protein 0.0165 0.1635 0.4763
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Brugia malayi MH1 domain containing protein 0.0024 0.0021 0.0031
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0057 0.0785
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0027 0.0057 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0044 0.025 0.0729
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0068 0.0519 0.7189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0912 0.3366
Plasmodium falciparum plasmepsin V 0.0023 0.0004 0.0019
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0197 0.0293
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0053 0.0357 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0552 0.0202
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Mycobacterium ulcerans lipase LipD 0.0071 0.0552 0.0362
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0057 0.0209
Trypanosoma brucei antigen, putative 0.0102 0.0912 0.3366
Loa Loa (eye worm) hypothetical protein 0.0071 0.0552 0.0822
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0004 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0552 0.0202
Schistosoma mansoni hypothetical protein 0.0165 0.1635 0.4763
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0091 0.0337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0248 0.0723
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0023 0.0004 0.0013
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0053 0.0357 0.4938
Echinococcus multilocularis importin subunit beta 1 0.003 0.0091 0.0103
Loa Loa (eye worm) hypothetical protein 0.024 0.2487 0.3703
Plasmodium falciparum multidrug resistance protein 1 0.0053 0.0357 0.1955
Schistosoma mansoni hypothetical protein 0.0323 0.3433 1
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0914 0.1361
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Trichomonas vaginalis hypothetical protein 0.0031 0.0096 0.1335
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0057 0.0311
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0053 0.0357 0.4938
Plasmodium falciparum plasmepsin IV 0.0023 0.0004 0.0019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Loa Loa (eye worm) hypothetical protein 0.0071 0.0552 0.0822
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Loa Loa (eye worm) hypothetical protein 0.0061 0.0448 0.0668
Loa Loa (eye worm) hypothetical protein 0.0053 0.0357 0.0531
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0295 0.0861
Onchocerca volvulus 0.0071 0.0552 0.2026
Loa Loa (eye worm) hypothetical protein 0.027 0.2837 0.4225
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0057 0.0084
Giardia lamblia Cathepsin B precursor 0.0044 0.0248 0.3437
Echinococcus granulosus multidrug resistance protein 1 0.0037 0.0172 0.0492
Schistosoma mansoni multidrug resistance protein 0.0053 0.0357 0.1039
Echinococcus granulosus cathepsin b 0.0133 0.1268 0.3623
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0057 0.0785
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0021 0.0023
Schistosoma mansoni hypothetical protein 0.0031 0.0096 0.0281
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0026 0.0096
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0085 0.0722 1
Echinococcus multilocularis multidrug resistance protein 1 0.0053 0.0357 0.0401
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0096 0.1335
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0068 0.0519 0.1512
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0096 0.0356
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0567 0.0639
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0053 0.0357 0.4938
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0057 0.0084
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0286 0.3014 0.3392
Brugia malayi proteasome subunit beta type 1 0.0068 0.0519 0.0773
Plasmodium falciparum plasmepsin VI 0.0023 0.0004 0.0019
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0197 0.0727
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0057 0.0165
Trichomonas vaginalis calpain, putative 0.0031 0.0096 0.1335
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0914 0.1361
Echinococcus multilocularis calpain 7 (C02 family) 0.0102 0.0912 0.1026
Trypanosoma brucei calpain, putative 0.0031 0.0096 0.0356
Leishmania major p-glycoprotein 0.0053 0.0357 0.1316
Loa Loa (eye worm) hypothetical protein 0.0071 0.0552 0.0822
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0144
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0057 0.0084
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0023 0.0004 0.0013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0096 0.0356
Leishmania major calpain protease-like protein 0.0031 0.0096 0.0356
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0552 0.1607
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0286 0.3014 0.878
Brugia malayi MH2 domain containing protein 0.0024 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0084
Brugia malayi Pepsin A precursor 0.0023 0.0004 0.0005
Trypanosoma brucei calpain-like protein, putative 0.0102 0.0912 0.3366
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.0357 0.1019
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Loa Loa (eye worm) hypothetical protein 0.0053 0.0357 0.0531
Brugia malayi Blistered cuticle protein 3 0.0102 0.0914 0.1361
Loa Loa (eye worm) hypothetical protein 0.0102 0.0914 0.1361
Trichomonas vaginalis ABC transporter, putative 0.0053 0.0357 0.4938
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0552 0.0202
Echinococcus granulosus calpain 5 0.0102 0.0912 0.2606
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0552 0.0822
Trichomonas vaginalis abcb9, putative 0.0053 0.0357 0.4938
Toxoplasma gondii aspartyl protease 0.0023 0.0004 0.0013
Echinococcus multilocularis multidrug resistance protein 1 0.0053 0.0357 0.0401
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Mycobacterium ulcerans hypothetical protein 0.0071 0.0552 0.0362
Echinococcus multilocularis prolyl endopeptidase 0.0259 0.271 0.3049
Brugia malayi aspartic protease BmAsp-2, identical 0.0023 0.0004 0.0005
Brugia malayi beta-lactamase family protein 0.0071 0.0552 0.0822
Trypanosoma brucei cysteine peptidase, putative 0.0031 0.0096 0.0356
Plasmodium falciparum calpain 0.0031 0.0096 0.0529
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0085 0.0722 0.2665
Echinococcus multilocularis cathepsin b 0.0133 0.1268 0.1427
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0044 0.025 0.0715
Onchocerca volvulus Dual oxidase homolog 0.0102 0.0914 0.3366
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0096 0.1335
Leishmania major hypothetical protein, conserved 0.0031 0.0096 0.0356
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0085 0.0722 0.1075
Brugia malayi Proteasome A-type and B-type family protein 0.0085 0.0722 0.1075
Entamoeba histolytica calpain large subunit domain III containing protein 0.0071 0.0561 0.7776
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0248 0.3437
Brugia malayi prolyl oligopeptidase family protein 0.0259 0.271 0.4035
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0053 0.0357 0.0401
Onchocerca volvulus 0.0102 0.0914 0.3366
Brugia malayi Eukaryotic aspartyl protease family protein 0.0023 0.0004 0.0005
Echinococcus multilocularis hypothetical protein 0.0102 0.0912 0.1026
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.0357 0.1019
Giardia lamblia Cathepsin B precursor 0.0044 0.0248 0.3437
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0103 0.0924 0.3412
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0053 0.0357 0.1019
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0044 0.025 0.3465
Trypanosoma cruzi prolyl endopeptidase 0.0259 0.271 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0259 0.271 1
Onchocerca volvulus 0.0102 0.0914 0.3366
Echinococcus multilocularis calpain 5 0.0102 0.0912 0.1026
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0552 0.2036
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0026 0.0142
Brugia malayi ABC transporter family protein 0.0053 0.0357 0.0531
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0091 0.0337
Plasmodium vivax aspartyl protease, putative 0.0182 0.1823 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Trypanosoma brucei prolyl endopeptidase 0.0259 0.271 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.061 0.6715 1
Leishmania major hypothetical protein, conserved 0.0025 0.0026 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0197 0.0293
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0057 0.0785
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0004 0.001
Trypanosoma cruzi conserved protein 0.0031 0.0096 0.0356
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0068 0.0519 0.0584
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0057 0.0165
Trypanosoma brucei Calpain-like protein 1.2 0.0031 0.0096 0.0356
Onchocerca volvulus 0.0048 0.0295 0.1079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0084
Schistosoma mansoni Mername-AA248 (C02 family) 0.0102 0.0912 0.2657
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0259 0.271 0.7894
Loa Loa (eye worm) fli-1 protein 0.0218 0.224 0.3336
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0102 0.0912 0.3366
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0068 0.0519 0.1483
Brugia malayi Cytochrome P450 family protein 0.0039 0.0197 0.0293
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0057 0.0162
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0031 0.0096 0.1335
Plasmodium vivax proteasome subunit beta type-5, putative 0.0085 0.0722 0.396
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0037 0.0172 0.2384
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0085 0.0722 0.2104
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0027 0.0057 0.0209
Plasmodium vivax proteasome subunit beta type-1, putative 0.0068 0.0519 0.2847
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0102 0.0912 0.3366
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0027 0.0057 0.0209
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0085 0.0722 0.2665
Echinococcus granulosus smad 0.0024 0.0021 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0026 0.0096
Plasmodium falciparum plasmepsin VII 0.0023 0.0004 0.0019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Toxoplasma gondii proteasome subunit beta type, putative 0.0085 0.0722 0.2665
Schistosoma mansoni gabp alpha 0.0072 0.0567 0.1653
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0914 0.1361
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0197 0.0727
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0552 0.0621
Leishmania major proteasome beta 2 subunit, putative 0.0044 0.025 0.0923
Echinococcus granulosus calpain A 0.0286 0.3016 0.8618
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0057 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Loa Loa (eye worm) Smad1 0.0024 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0005
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0027 0.0057 0.0162
Echinococcus granulosus geminin 0.0165 0.1635 0.467
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0057 0.0785
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0057 0.0785
Loa Loa (eye worm) transcription factor SMAD2 0.0353 0.3778 0.5626
Loa Loa (eye worm) hypothetical protein 0.0133 0.1268 0.1888
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0096 0.0356
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0057 0.0785
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0068 0.0519 0.2847
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0023 0.0004 0.0004
Loa Loa (eye worm) cathepsin B 0.0044 0.0248 0.037
Plasmodium falciparum plasmepsin IX 0.0182 0.1823 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0023 0.0004 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0254 0.0286
Entamoeba histolytica P-glycoprotein-2 0.0053 0.0357 0.4938
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0044 0.025 0.0282
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0026 0.0358
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0026 0.0358
Mycobacterium ulcerans proteasome PrcB 0.0085 0.0722 0.0536

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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