Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.1481 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1481 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.1481 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1481 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0566 | 0.3151 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0566 | 0.3151 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0378 | 0.1738 | 0.1738 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1481 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0566 | 0.3151 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1481 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0566 | 0.3151 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.1481 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0566 | 0.3151 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1481 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1481 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0566 | 0.3151 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.