Detailed information for compound 888313

Basic information

Technical information
  • TDR Targets ID: 888313
  • Name: methyl N-[2-[2-[(2-acetyl-4-fluorophenoxy)met hyl]morpholin-4-yl]-2-oxoethyl]carbamate
  • MW: 368.357 | Formula: C17H21FN2O6
  • H donors: 1 H acceptors: 3 LogP: 0.62 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)NCC(=O)N1CCOC(C1)COc1ccc(cc1C(=O)C)F
  • InChi: 1S/C17H21FN2O6/c1-11(21)14-7-12(18)3-4-15(14)26-10-13-9-20(5-6-25-13)16(22)8-19-17(23)24-2/h3-4,7,13H,5-6,8-10H2,1-2H3,(H,19,23)
  • InChiKey: QLPQODMYJQBQAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl N-[2-[2-[(2-acetyl-4-fluoro-phenoxy)methyl]morpholin-4-yl]-2-oxo-ethyl]carbamate
  • N-[2-[2-[(2-acetyl-4-fluorophenoxy)methyl]-4-morpholinyl]-2-oxoethyl]carbamic acid methyl ester
  • N-[2-[2-[(2-acetyl-4-fluoro-phenoxy)methyl]morpholin-4-yl]-2-keto-ethyl]carbamic acid methyl ester
  • methyl N-[2-[2-[(2-ethanoyl-4-fluoro-phenoxy)methyl]morpholin-4-yl]-2-oxo-ethyl]carbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0001 0.0227
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0091 0.0537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Onchocerca volvulus 0.0037 0.002 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0015 0.0015
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0002 0.0215
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0014 1
Echinococcus multilocularis protein patched 0.0045 0.0026 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 1.0841 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.0039 0.0038
Onchocerca volvulus 0.0101 0.0078 0.0407
Brugia malayi hypothetical protein 0.1832 0.1677 0.1677
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0005 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0017 0.1721
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0015 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0003 0.0002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0017 0.514
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0002 0.0001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0017 0.0016
Plasmodium vivax JmjC domain containing protein 0.0018 0.0002 0.0472
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0026 0.0025
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0002 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Schistosoma mansoni aryl hydrocarbon receptor 0.0105 0.0082 0.0081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.0107 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0043 0.0042
Loa Loa (eye worm) carboxylesterase 0.1832 0.1677 0.1677
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.001 0.0055
Echinococcus granulosus BC026374 protein S09 family 0.1832 0.1677 0.1677
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0045 0.4217
Onchocerca volvulus 0.0065 0.0045 0.0209
Loa Loa (eye worm) hypothetical protein 0.0098 0.0076 0.0076
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0015 0.0014
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.002 0.011
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0078 0.0078
Loa Loa (eye worm) beta-lactamase 0.0037 0.002 0.0019
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0091 0.009
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0011 0.0057
Brugia malayi hypothetical protein 0.0128 0.0104 0.0104
Onchocerca volvulus 0.1832 0.1677 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.002 0.011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0148 0.0122 0.0121
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.002 0.011
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0015 0.0015
Brugia malayi 6-phosphofructokinase 0.0115 0.0091 0.0091
Leishmania major protein kinase, putative 0.0027 0.001 0.0867
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0001 0.0112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0015 0.0014
Mycobacterium ulcerans lipase LipD 0.0037 0.002 0.011
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0014 0.3033
Plasmodium falciparum glutathione reductase 0.005 0.0031 1
Brugia malayi beta-lactamase family protein 0.0037 0.002 0.0019
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0081 0.0081
Mycobacterium leprae Probable lipase LipE 0.0037 0.002 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0019
Onchocerca volvulus 0.1832 0.1677 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0015 0.0015
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0014 0.1291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0015 0.0014
Echinococcus multilocularis BC026374 protein (S09 family) 0.1832 0.1677 0.1677
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0091 0.1432
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.001 0.0009
Loa Loa (eye worm) RecQ helicase 0.0024 0.0007 0.0007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0006 0.1496
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0017 0.0016
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0002 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0107 0.0633
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Brugia malayi CHE-14 protein 0.0045 0.0026 0.0026
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0004
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0014 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0015 0.0015
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.002 0.011
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0011 0.3151
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0002 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0045 0.0044
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0031 0.003
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0005 0.0005
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.009 0.0532
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0015 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.002 0.011
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.001 0.0009
Brugia malayi phosphofructokinase 0.0115 0.0091 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0015 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0148 0.0122 0.0121
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.001 0.0055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0006 0.0027
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0023
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.001 0.0055
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1832 0.1677 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.002 0.2045
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.002 0.011
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.002 0.0019
Onchocerca volvulus 0.0037 0.002 0.0055
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.0494 0.0442 0.0441
Schistosoma mansoni hypothetical protein 0.0043 0.0025 0.0024
Trichomonas vaginalis spcc417.12 protein, putative 0.1832 0.1677 1
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0015 0.0014
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.009 0.0532
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0049 0.0048
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.001 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0006 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0015 0.0015
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.0205 0.1215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0015 0.0014
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0005 0.0004
Loa Loa (eye worm) carboxylesterase 1.0841 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0081 0.008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0081 0.1266
Brugia malayi nuclear hormone receptor 0.0032 0.0015 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0015 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0091 0.8478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0091 0.0537
Plasmodium vivax hypothetical protein, conserved 0.0037 0.002 0.4309
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0015 0.0015
Echinococcus granulosus expressed protein 0.0419 0.0372 0.0371
Brugia malayi beta-lactamase family protein 0.0037 0.002 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0015 0.0014
Brugia malayi Carboxylesterase family protein 0.1832 0.1677 0.1677
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0091 0.2903
Onchocerca volvulus 0.1832 0.1677 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0019
Loa Loa (eye worm) glutaminase 2 0.0589 0.053 0.0529
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0049 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0076
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0091 0.0091
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0005 0.0004
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.001 0.1022
Echinococcus multilocularis expressed conserved protein 0.0098 0.0075 0.0074
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0049 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0045 0.0044
Schistosoma mansoni patched 1 0.0045 0.0026 0.0025
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0091 0.009
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0045 0.0045
Schistosoma mansoni gliotactin 0.1832 0.1677 0.1677
Schistosoma mansoni hypothetical protein 0.0043 0.0025 0.0024
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.001 0.0009
Brugia malayi intermediate filament protein 0.003 0.0013 0.0013
Schistosoma mansoni single-minded 0.0105 0.0082 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.002 0.011
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0017 0.0016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.001 0.0055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.0107 0.0106
Loa Loa (eye worm) hypoxia-induced factor 1 0.0325 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0017 0.0016
Loa Loa (eye worm) glutathione reductase 0.005 0.0031 0.0031
Echinococcus multilocularis lamin 0.003 0.0013 0.0012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0011 0.2332
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0007 0.0037
Schistosoma mansoni ap endonuclease 0.0022 0.0006 0.0005
Echinococcus multilocularis neuroligin 0.1832 0.1677 0.1677
Brugia malayi Pre-SET motif family protein 0.0065 0.0045 0.0045
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0002 0.0123
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0005 0.0005
Brugia malayi 6-phosphofructokinase 0.0115 0.0091 0.0091
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0002 0.0001
Mycobacterium tuberculosis Carboxylesterase LipT 0.1832 0.1677 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0019
Echinococcus granulosus phd:f box containing protein 0.0018 0.0002 0.0001
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0014 0.4201
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0005 0.0004
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0107 0.0633
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0004
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0091 0.1432
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0005 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0015 0.0015
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0017 0.0092
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0673 0.0607 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0006 0.0074
Schistosoma mansoni ap endonuclease 0.0022 0.0006 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0007 0.0037
Echinococcus granulosus single minded 2 0.0078 0.0057 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0006 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0015 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.001 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.002 0.011
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0015 0.0014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0015 0.0014
Trichomonas vaginalis esterase, putative 0.0037 0.002 0.011
Schistosoma mansoni coup transcription factor 0.0032 0.0015 0.0014
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0005 0.0004
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0004
Onchocerca volvulus 0.0098 0.0076 0.0392
Loa Loa (eye worm) hypothetical protein 1.0841 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0673 0.0607 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0011 0.0057
Echinococcus granulosus lamin dm0 0.003 0.0013 0.0012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0006 0.0005
Onchocerca volvulus 0.0037 0.002 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0015 0.0015
Onchocerca volvulus 0.1832 0.1677 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0006 0.0501
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0005 0.0005
Onchocerca volvulus 0.003 0.0013 0.0017
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0002 0.0001
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0005 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Toxoplasma gondii exonuclease III APE 0.0022 0.0006 0.0532
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0004
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0005 0.1146
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0005 0.0005
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0002 0.0367
Echinococcus multilocularis lamin dm0 0.003 0.0013 0.0012
Echinococcus granulosus L aminoadipate semialdehyde 0.0098 0.0076 0.0075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0049 0.0048
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.009 0.0532
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0014 0.1291
Mycobacterium tuberculosis Conserved protein 0.0037 0.002 0.011
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0004
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0005 0.0004
Mycobacterium ulcerans putative regulatory protein 0.0078 0.0057 0.0332
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0005 0.0004
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0014 0.3033
Echinococcus multilocularis L aminoadipate semialdehyde 0.0098 0.0076 0.0075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.002 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.009 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0023
Brugia malayi jmjC domain containing protein 0.0069 0.0049 0.0049
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.001 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.002 0.011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0005 0.0005
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0011 0.0894
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.0107 1
Brugia malayi Carboxylesterase family protein 0.1832 0.1677 0.1677
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.002 0.2045
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.009 0.2874
Schistosoma mansoni acetylcholinesterase 0.1832 0.1677 0.1677
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0076
Echinococcus granulosus acetylcholinesterase 1.0841 1 1
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0023
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0017 0.1721
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0005 0.0004
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1832 0.1677 0.1677
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.001 0.1022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.009 0.0532
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0015 0.0014
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.001 0.1022
Mycobacterium ulcerans carboxylesterase, LipT 0.1832 0.1677 1
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 1.0841 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0031 0.003
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0081 0.008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.002 0.011
Mycobacterium ulcerans glutaminase 0.0589 0.053 0.3153
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0006 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0107 0.0106
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.001 0.0055
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1832 0.1677 1
Echinococcus granulosus expressed conserved protein 0.0098 0.0075 0.0074
Brugia malayi jmjC domain containing protein 0.0018 0.0002 0.0002
Echinococcus granulosus intermediate filament protein 0.003 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.002 0.2045
Schistosoma mansoni lamin 0.003 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0352 0.031 0.031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0037 0.002 0.1734
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0015 0.0014
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0005 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.002 0.0019
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0002 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.002 0.011
Brugia malayi hypothetical protein 0.0022 0.0005 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0006 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0015 0.0028
Schistosoma mansoni hypothetical protein 0.0043 0.0025 0.0024
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0001 0.0112
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1832 0.1677 0.1677
Brugia malayi jmjC domain containing protein 0.0069 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1832 0.1677 0.1677
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0015 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0015 0.0015
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0014 0.0146
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0002 0.0215
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0091 0.0537
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0015 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0015 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Trichomonas vaginalis set domain proteins, putative 0.0516 0.0462 0.2747
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0329 0.0289 0.1715
Leishmania major trypanothione reductase 0.005 0.0031 0.2838
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0002 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0002 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.002 0.011
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0014 0.0209
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0005 0.0004
Plasmodium vivax SET domain protein, putative 0.0065 0.0045 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0102 0.0602
Mycobacterium tuberculosis Probable reductase 0.0114 0.009 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0005 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0015 0.0015
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0011 1
Schistosoma mansoni hypothetical protein 0.0043 0.0025 0.0024
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0005 0.0005
Loa Loa (eye worm) intermediate filament protein 0.003 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0015 0.0014
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0002 0.0001
Echinococcus multilocularis musashi 0.003 0.0013 0.0012
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0005 0.0004
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0002 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0011 0.001
Brugia malayi steroid hormone receptor 0.0032 0.0015 0.0015
Trichomonas vaginalis glutaminase, putative 0.0589 0.053 0.3153
Echinococcus multilocularis protein dispatched 1 0.0051 0.0032 0.0031
Brugia malayi Carboxylesterase family protein 0.1832 0.1677 0.1677
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0091 0.0537
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0006 0.0005
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0329 0.0289 0.1715
Toxoplasma gondii thioredoxin reductase 0.005 0.0031 0.2918
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0005 0.0005
Echinococcus granulosus acetylcholinesterase 1.0841 1 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.001 0.0055
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.001 0.0055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0015 0.0014
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Onchocerca volvulus 0.003 0.0013 0.0017
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0005 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0015 0.0014
Echinococcus multilocularis expressed protein 0.0419 0.0372 0.0371
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0015 0.0014
Echinococcus multilocularis para nitrobenzyl esterase 0.1832 0.1677 0.1677
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0002 0.0001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1832 0.1677 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0014 0.0076
Schistosoma mansoni glutaminase 0.0589 0.053 0.0529
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.001 0.0009
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0335 0.0295 0.0294
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0102 0.0602
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0026 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0091 0.0537
Trypanosoma brucei trypanothione reductase 0.005 0.0031 0.3347
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0002 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0107 0.0633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0673 0.0607 0.3611
Brugia malayi bHLH-PAS transcription factor 0.0078 0.0057 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0006 0.0501
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0091 0.009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0017 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0453 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.001 0.0867
Echinococcus multilocularis acetylcholinesterase 1.0841 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0002 0.0002
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0011 0.0996
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0014 0.0209
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0002 0.0002
Loa Loa (eye worm) glutaminase 0.0589 0.053 0.0529
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0015 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0045 0.0044
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0017 0.1554
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.001 0.1022
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0017 0.1459
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0031 0.018
Echinococcus granulosus bloom syndrome protein 0.0024 0.0007 0.0006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0091 0.1487
Schistosoma mansoni hypothetical protein 0.0365 0.0323 0.0322
Treponema pallidum fructose-bisphosphate aldolase 0.0673 0.0607 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.002 0.011
Echinococcus multilocularis geminin 0.0365 0.0323 0.0322
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0002 0.0123
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0026 0.0026
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0011 0.0057
Brugia malayi hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis transfer RNA-Lys 0.0078 0.0057 0.0056
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0006 0.0006
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0005 0.0004
Brugia malayi nuclear receptor NHR-88 0.0032 0.0015 0.0015
Echinococcus granulosus carboxylesterase 5A 1.0841 1 1
Onchocerca volvulus 0.0078 0.0057 0.0279
Schistosoma mansoni lamin 0.003 0.0013 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0181 0.0152 0.0151
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0049 0.0048
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0017 0.1721
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0006 0.0006
Schistosoma mansoni intermediate filament proteins 0.003 0.0013 0.0012
Loa Loa (eye worm) acetylcholinesterase 1 1.0841 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0494 0.0442 0.0441
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0045 0.0044
Brugia malayi Carboxylesterase family protein 0.1832 0.1677 0.1677
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0045 0.0044
Schistosoma mansoni survival motor neuron protein 0.0101 0.0078 0.0077
Brugia malayi hypothetical protein 0.0494 0.0442 0.0441
Brugia malayi Carboxylesterase family protein 1.0841 1 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0101 0.0078 0.0077
Echinococcus granulosus para nitrobenzyl esterase 0.1832 0.1677 0.1677
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0005 0.0004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0006 0.4748
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0098 0.0076 0.0075
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0007 0.0007
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.001 0.0055
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0122 0.0121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0015 0.0014
Mycobacterium ulcerans beta-lactamase 0.0037 0.002 0.011
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0017 0.1554
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0091 0.1432
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.0107 0.0633
Loa Loa (eye worm) hypothetical protein 0.1832 0.1677 0.1677
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.001 0.727
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0006 0.1226
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.002 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0015 0.0015
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.002 0.011
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0002 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0102 0.0602
Echinococcus multilocularis carboxylesterase 5A 1.0841 1 1
Brugia malayi glutathione reductase 0.005 0.0031 0.0031
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0011 0.75
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0091 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0017 0.0016
Mycobacterium tuberculosis Conserved protein 0.0037 0.002 0.011
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0015 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0045 0.0044
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0017 0.1721
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0005 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1832 0.1677 0.1677
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0049 0.0049
Leishmania major hypothetical protein, conserved 0.0018 0.0002 0.0104
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0102 0.3296
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0049 0.0048
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0006 0.0425
Brugia malayi PXA domain containing protein 0.0022 0.0005 0.0005
Onchocerca volvulus 0.1832 0.1677 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.002 0.0019
Echinococcus granulosus lamin 0.003 0.0013 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0026 0.015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.002 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0076
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0012
Onchocerca volvulus 0.0516 0.0462 0.2707
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0091 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.001 0.1022
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0107 0.0106
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0001 0.0227
Toxoplasma gondii ABC1 family protein 0.0037 0.002 0.1826
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0091 0.0537
Echinococcus granulosus neuroligin 0.1832 0.1677 0.1677
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0031 0.3347
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0026 0.0025
Loa Loa (eye worm) carboxylesterase 0.1832 0.1677 0.1677
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0015 0.0014
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0002 0.0123
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0049 0.0048
Echinococcus multilocularis survival motor neuron protein 1 0.0494 0.0442 0.0441
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0013 0.0013
Plasmodium vivax glutathione reductase, putative 0.005 0.0031 0.6908
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0104 0.0081 0.0081
Echinococcus granulosus geminin 0.0365 0.0323 0.0322
Brugia malayi ecdysteroid receptor 0.0032 0.0015 0.0015
Schistosoma mansoni neuroligin 3 (S09 family) 0.1832 0.1677 0.1677
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0083 0.0082
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0098 0.0076 0.0076
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0017 0.3661
Plasmodium falciparum thioredoxin reductase 0.005 0.0031 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.001 0.0055
Echinococcus multilocularis acetylcholinesterase 1.0841 1 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.002 0.011
Brugia malayi hypoxia-induced factor 1 0.0325 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0028 0.0011 0.0093
Leishmania major protein kinase, putative 0.0027 0.001 0.0867
Brugia malayi beta-lactamase 0.0037 0.002 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0031 0.6908
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1832 0.1677 0.1677
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0148 0.0122 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0005 0.0004
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0091 0.0091
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0006 0.0501
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0014 0.1291
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0015 0.0015
Giardia lamblia Fructose-bisphosphate aldolase 0.0673 0.0607 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0006 0.0074
Brugia malayi isocitrate dehydrogenase 0.0034 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0014 0.0076
Brugia malayi Pre-SET motif family protein 0.0453 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.0035
Brugia malayi PAS domain containing protein 0.0105 0.0082 0.0082
Brugia malayi hypothetical protein 0.0352 0.031 0.031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0017 0.0016
Brugia malayi PXA domain containing protein 0.0022 0.0005 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0181 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0005 0.0005
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0026 0.0025
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0011 0.0157
Brugia malayi Thioredoxin reductase 0.005 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0019
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0329 0.0289 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0011 0.1055
Schistosoma mansoni thyroid hormone receptor 0.0181 0.0152 0.0151
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.0019
Schistosoma mansoni BC026374 protein (S09 family) 0.1832 0.1677 0.1677
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0014 0.4201
Brugia malayi glutaminase DH11.1 0.0589 0.053 0.0529
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0365 0.0323 0.0322
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0005 0.0023
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.001 0.1022
Brugia malayi nuclear receptor RXR 0.0017 0.0001 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0037 0.002 0.0331
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0011 0.0996
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0015 0.0028
Onchocerca volvulus 0.0032 0.0015 0.0028
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0015 0.0014
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0091 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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