Detailed information for compound 888414

Basic information

Technical information
  • TDR Targets ID: 888414
  • Name: 2-methyl-1-[2-(2-pyridin-3-yl1,3-thiazole-4-c arbonyl)pyrazolidin-1-yl]prop-2-en-1-one
  • MW: 328.389 | Formula: C16H16N4O2S
  • H donors: 0 H acceptors: 4 LogP: 2.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=C)C(=O)N1CCCN1C(=O)c1csc(n1)c1cccnc1
  • InChi: 1S/C16H16N4O2S/c1-11(2)15(21)19-7-4-8-20(19)16(22)13-10-23-14(18-13)12-5-3-6-17-9-12/h3,5-6,9-10H,1,4,7-8H2,2H3
  • InChiKey: LFQSCQDCSMASRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-1-[2-[2-(3-pyridyl)thiazole-4-carbonyl]pyrazolidin-1-yl]prop-2-en-1-one
  • 2-methyl-1-[2-[oxo-[2-(3-pyridyl)-4-thiazolyl]methyl]-1-pyrazolidinyl]prop-2-en-1-one
  • 2-methyl-1-[2-[(2-pyridin-3-yl-1,3-thiazol-4-yl)carbonyl]pyrazolidin-1-yl]prop-2-en-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0938 0.2923
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0101 0.0315
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2157 0.6724
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0067 0.0067
Brugia malayi Smad1 0.0008 0.0065 0.0202
Brugia malayi oxidoreductase 0.0008 0.0067 0.0208
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0101 0.0138
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0342 0.7298 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0933 0.1279
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0285 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0101 0.0101
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0067 0.0208
Schistosoma mansoni carbonyl reductase 0.0008 0.0067 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0285 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0065 0.0202
Schistosoma mansoni smad1 5 8 and 0.0008 0.0065 0.0089
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0067 0.0067
Brugia malayi ecdysteroid receptor 0.001 0.0101 0.0315
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0101 0.0101
Schistosoma mansoni nuclear hormone receptor 0.001 0.0101 0.0138
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1215 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0065 0.0065
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0101 0.0138
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1215 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0101 0.0315
Wolbachia endosymbiont of Brugia malayi molecular chaperone DnaK 0.0009 0.0084 0.0775
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0067 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0938 0.0938
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0067 0.0092
Trichomonas vaginalis heat shock protein, putative 0.0009 0.0084 0.0775
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0067 0.0092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0285 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0101 0.0315
Plasmodium vivax heat shock protein 70, putative 0.0009 0.0084 0.0775
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0101 0.0315
Brugia malayi MH2 domain containing protein 0.0008 0.0065 0.0202
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0067 0.0067
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative 0.0009 0.0084 0.0775
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0101 0.0315
Trypanosoma brucei heat shock 70 kDa protein, mitochondrial precursor, putative 0.0009 0.0084 0.0775
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0101 0.0315
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.2727 0.8501
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0067 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0101 0.0101
Onchocerca volvulus 0.0009 0.0084 0.496
Brugia malayi MH2 domain containing protein 0.0008 0.0065 0.0202
Schistosoma mansoni hypothetical protein 0.0048 0.0938 0.1285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Schistosoma mansoni carbonyl reductase 0.0008 0.0067 0.0092
Brugia malayi TAR-binding protein 0.0131 0.2727 0.8501
Echinococcus multilocularis geminin 0.0342 0.7298 0.7298
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0933 0.0933
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.3208 1
Leishmania major heat shock 70-related protein 1, mitochondrial precursor, putative 0.0009 0.0084 0.0147
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0067 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0933 0.0933
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0101 0.0315
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0285 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0048 0.0938 0.1285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0933 0.291
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2498 0.7787
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Entamoeba histolytica mitochondrial-type heat shock protein 70 0.0009 0.0084 0.0775
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0285 1
Echinococcus granulosus oxidoreductase 0.0008 0.0067 0.0067
Schistosoma mansoni ap endonuclease 0.0018 0.0285 0.0391
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Loa Loa (eye worm) hypothetical protein 0.0009 0.0084 0.0261
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Schistosoma mansoni smad 0.0008 0.0065 0.0089
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0101 0.0101
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1215 0.1665
Onchocerca volvulus Heat shock 70 kDa protein F, mitochondrial homolog 0.0009 0.0084 0.496
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0101 0.0138
Echinococcus multilocularis heat shock protein 70 0.0009 0.0084 0.0084
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2498 0.7787
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0067 0.0208
Echinococcus multilocularis heat shock 70 kDa protein, mitochondrial precursor, putative 0.0009 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0065 0.0065
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi RNA binding protein 0.0131 0.2727 0.8501
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0067 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi nuclear hormone receptor 0.001 0.0101 0.0315
Echinococcus granulosus neuropeptide receptor A26 0.0466 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0067 0.0067
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0067 0.0067
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0067 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0101 0.0315
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0101 0.0315
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0101 0.0315
Leishmania major heat shock 70-related protein 1, mitochondrial precursor, putative 0.0009 0.0084 0.0147
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) Smad1 0.0008 0.0065 0.0202
Loa Loa (eye worm) RNA binding protein 0.0131 0.2727 0.8501
Echinococcus granulosus smad 0.0008 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0101 0.0315
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1215 0.1215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0101 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0101 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0101 0.0315
Echinococcus granulosus heat shock protein 70 0.0009 0.0084 0.0084
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Schistosoma mansoni carbonyl reductase 0.0008 0.0067 0.0092
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0101 0.0315
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0101 0.0315
Loa Loa (eye worm) hypothetical protein 0.0048 0.0938 0.2923
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0285 1
Echinococcus granulosus geminin 0.0342 0.7298 0.7298
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0101 1
Schistosoma mansoni heat shock protein 70 0.0009 0.0084 0.0115
Schistosoma mansoni heat shock protein 70 0.0009 0.0084 0.0115
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0131 0.2727 0.3737
Schistosoma mansoni hypothetical protein 0.0105 0.2157 0.2956
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.3208 1
Trichomonas vaginalis heat shock protein, putative 0.0009 0.0084 0.0775
Echinococcus multilocularis Smad4 0.0008 0.0065 0.0065
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0285 0.0889
Echinococcus granulosus tar DNA binding protein 0.0131 0.2727 0.2727
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0067 0.0067
Entamoeba histolytica heat shock protein 70, mitochondrial, putative 0.0009 0.0084 0.0775
Brugia malayi MH1 domain containing protein 0.0008 0.0065 0.0202
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0101 0.0101
Leishmania major heat shock 70-related protein 1, mitochondrial precursor, putative 0.0009 0.0084 0.0147
Echinococcus multilocularis neuropeptide receptor A26 0.0466 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0285 0.1902
Trypanosoma brucei heat shock 70 kDa protein, mitochondrial precursor, putative 0.0009 0.0084 0.0775
Loa Loa (eye worm) hypothetical protein 0.0009 0.0084 0.0261
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0101 0.0101
Leishmania major heat shock 70-related protein 1, mitochondrial precursor, putative 0.0009 0.0084 0.0147
Leishmania major heat shock 70-related protein 1, mitochondrial precursor, putative 0.0009 0.0084 0.0147
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0067 0.0067
Mycobacterium ulcerans chaperone protein DnaK1 0.0009 0.0084 0.0147
Plasmodium falciparum heat shock protein 70 0.0009 0.0084 0.0775
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0101 0.0101
Schistosoma mansoni thyroid hormone receptor 0.001 0.0101 0.0138
Loa Loa (eye worm) hypothetical protein 0.0105 0.2157 0.6724
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0065 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0933 0.0933
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0285 0.1902
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0067 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0285 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi steroid hormone receptor 0.001 0.0101 0.0315
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0285 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0101 0.0315
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1215 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1215 0.1215
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0101 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN DNAK (HEAT SHOCK PROTEIN 70) (HEAT SHOCK 70 KDA PROTEIN) (HSP70) 0.0009 0.0084 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Trypanosoma brucei heat shock 70 kDa protein, mitochondrial precursor, putative 0.0009 0.0084 0.0775
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0065 0.0089
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0067 0.0067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0101 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0101 0.0315
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0067 0.0067
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0101 0.0101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.3208 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.3208 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0933 0.1279
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi MH1 domain containing protein 0.0008 0.0065 0.0202
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Toxoplasma gondii exonuclease III APE 0.0018 0.0285 0.1902
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0938 0.2923
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0067 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0101 0.0315
Schistosoma mansoni ap endonuclease 0.0018 0.0285 0.0391
Echinococcus multilocularis GPCR, family 2 0.0048 0.0938 0.0938
Toxoplasma gondii heat shock protein 0.0009 0.0084 0.0147
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0938 0.0938
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Schistosoma mansoni thyroid hormone receptor 0.001 0.0101 0.0138
Schistosoma mansoni Smad4 0.0008 0.0065 0.0089
Brugia malayi hypothetical protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0067 0.0208
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0101 0.0138
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0101 0.0315
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0067 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0101 0.0101
Brugia malayi nuclear receptor NHR-88 0.001 0.0101 0.0315
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0285 0.1902
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0067 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0131 0.2727 0.3737
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Trypanosoma cruzi heat shock 70 kDa protein, mitochondrial precursor, putative 0.0009 0.0084 0.0775
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0101 0.0315
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0933 0.1279
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0285 0.0889
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0101 0.0315
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0067 0.0067
Echinococcus granulosus GPCR family 2 0.0048 0.0938 0.0938
Echinococcus multilocularis neuropeptide s receptor 0.0466 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0067 0.0067
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0285 1
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0067 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1215 1
Loa Loa (eye worm) TAR-binding protein 0.0131 0.2727 0.8501
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0067 0.0067
Onchocerca volvulus 0.001 0.0101 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Echinococcus multilocularis tar DNA binding protein 0.0131 0.2727 0.2727
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0101 0.0101
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0067 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Schistosoma mansoni smad1 5 8 and 0.0008 0.0065 0.0089
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0101 0.0101
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0067 0.0067
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0067 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0131 0.2727 0.3737
Loa Loa (eye worm) dehydrogenase 0.0008 0.0067 0.0208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0938 0.0938
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0101 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0067 0.0208
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0101 0.0138
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0101 0.0138
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0067 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0008 0.0067 0.0208
Echinococcus granulosus hypothetical protein 0.0008 0.0067 0.0067
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0101 0.0101
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0285 1
Echinococcus granulosus hypothetical protein 0.0008 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1215 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0065 0.0065
Loa Loa (eye worm) oxidoreductase 0.0008 0.0067 0.0208
Echinococcus granulosus FTZ F1 alpha 0.001 0.0101 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0101 0.0101
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0067 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0101 0.0315
Schistosoma mansoni hypothetical protein 0.0048 0.0938 0.1285
Echinococcus multilocularis oxidoreductase 0.0008 0.0067 0.0067
Brugia malayi hypothetical protein 0.0008 0.0067 0.0208
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0067 0.0208
Entamoeba histolytica heat shock protein 70, mitochondrial, putative 0.0009 0.0084 0.0775
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1215 0.1665
Mycobacterium tuberculosis Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70) 0.0009 0.0084 0.0147
Echinococcus multilocularis smad 0.0008 0.0065 0.0065
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1215 1
Mycobacterium ulcerans molecular chaperone DnaK 0.0009 0.0084 0.0147
Brugia malayi Heat shock 70 kDa protein F, mitochondrial precursor, putative 0.0009 0.0084 0.0261
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Chlamydia trachomatis chaperone protein DnaK 0.0009 0.0084 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0067 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0933 0.0933
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0067 0.0092
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0101 0.0315
Loa Loa (eye worm) dehydrogenase 0.0008 0.0067 0.0208
Loa Loa (eye worm) hypothetical protein 0.001 0.0101 0.0315
Schistosoma mansoni coup transcription factor 0.001 0.0101 0.0138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0067 0.0208
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Brugia malayi MH2 domain containing protein 0.012 0.2498 0.7787
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0067 0.0067
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0285 0.0285
Entamoeba histolytica heat shock protein70, mitochondrial, putative 0.0009 0.0084 0.0775
Echinococcus granulosus Smad4 0.0008 0.0065 0.0065
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0067 0.0092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0101 0.0138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0938 0.0938
Schistosoma mansoni tar DNA-binding protein 0.0131 0.2727 0.3737
Echinococcus granulosus stress 70 protein mitochondrial 0.0009 0.0084 0.0084
Schistosoma mansoni smad1 5 8 and 0.0008 0.0065 0.0089
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0933 0.291
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0101 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0101 0.0315
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0938 0.2923
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0067 0.0208
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0067 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0067 0.0208
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0342 0.7298 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.2727 0.3737
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.2727 0.8501
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0048 0.0938 0.1285
Entamoeba histolytica heat shock protein 70, mitochondrial, putative 0.0009 0.0084 0.0775

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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