Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2442 | 0.3603 | 0.3452 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.2442 | 0.3603 | 0.3603 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.2783 | 0.4227 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0602 | 0.023 | 0.023 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0768 | 0.0533 | 0.0533 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.2442 | 0.3603 | 0.3603 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.2442 | 0.3603 | 0.3452 |
Echinococcus granulosus | Protein patched homolog 1 | 0.2442 | 0.3603 | 0.3603 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.5932 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.2442 | 0.3603 | 0.3603 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.5932 | 1 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0602 | 0.023 | 0.023 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.5932 | 1 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0611 | 0.0246 | 0.0246 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2783 | 0.4227 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.2442 | 0.3603 | 0.3603 |
Loa Loa (eye worm) | hypothetical protein | 0.5932 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.2442 | 0.3603 | 0.3603 |
Echinococcus multilocularis | serotonin receptor | 0.0602 | 0.023 | 0.023 |
Echinococcus granulosus | hypothetical protein | 0.0826 | 0.064 | 0.064 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2783 | 0.4227 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.2442 | 0.3603 | 0.3603 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.2783 | 0.4227 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.5932 | 1 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0602 | 0.023 | 0.023 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.5932 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.2442 | 0.3603 | 0.3603 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.2442 | 0.3603 | 0.3603 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.5932 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.5932 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.5932 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.