Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.4318 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.2054 | 0.4667 | 0.4667 |
Giardia lamblia | CDC8 | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.4318 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.4318 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4318 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4318 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4318 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4318 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2054 | 0.4667 | 0.4667 |
Chlamydia trachomatis | thymidylate kinase | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.4318 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4318 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2054 | 0.4667 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4318 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.4318 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4318 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0073 | 0 | 0.5 |
Onchocerca volvulus | 0.4318 | 1 | 1 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.4318 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0073 | 0 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0073 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2054 | 0.4667 | 0.4667 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.