Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3145 | 0.3145 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0094 | 0.0985 | 0.0985 |
Echinococcus granulosus | acetylcholinesterase | 0.0556 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1465 | 0.1465 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0094 | 0.0985 | 0.6722 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1465 | 0.1465 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Echinococcus multilocularis | geminin | 0.0205 | 0.3145 | 0.3145 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0985 | 0.0985 |
Loa Loa (eye worm) | carboxylesterase | 0.0556 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0094 | 0.0985 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0985 | 0.0985 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0229 | 0.0229 |
Echinococcus multilocularis | acetylcholinesterase | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0094 | 0.0985 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Echinococcus granulosus | carboxylesterase 5A | 0.0556 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1465 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0094 | 0.0985 | 0.2154 |
Echinococcus multilocularis | neuroligin | 0.0094 | 0.0985 | 0.0985 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0229 | 0.0229 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0985 | 0.0985 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0229 | 0.0229 |
Onchocerca volvulus | 0.0094 | 0.0985 | 0.6722 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.4572 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0229 | 0.0229 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0094 | 0.0985 | 0.0985 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0094 | 0.0985 | 0.0985 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0229 | 0.0229 |
Echinococcus granulosus | geminin | 0.0205 | 0.3145 | 0.3145 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0094 | 0.0985 | 0.2154 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1465 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0556 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Schistosoma mansoni | acetylcholinesterase | 0.0094 | 0.0985 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0556 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0094 | 0.0985 | 0.2154 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.3145 | 0.3145 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0094 | 0.0985 | 1 |
Schistosoma mansoni | gliotactin | 0.0094 | 0.0985 | 0.0985 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0094 | 0.0985 | 0.0985 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0556 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0094 | 0.0985 | 0.0985 |
Onchocerca volvulus | 0.0094 | 0.0985 | 0.6722 | |
Onchocerca volvulus | 0.0094 | 0.0985 | 0.6722 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0229 | 0.0229 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0229 | 0.0229 |
Brugia malayi | Carboxylesterase family protein | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0094 | 0.0985 | 0.0985 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0094 | 0.0985 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0094 | 0.0985 | 0.0985 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0094 | 0.0985 | 0.0985 |
Onchocerca volvulus | 0.0094 | 0.0985 | 0.6722 | |
Echinococcus granulosus | acetylcholinesterase | 0.0556 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1465 | 0.1465 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0985 | 0.0985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.