Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | 0.0218 | 0.7835 | 0.7835 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0044 | 0.0325 | 0.0217 |
Schistosoma mansoni | glutaminase | 0.0268 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.7835 | 0.7835 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0132 | 0.5 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0039 | 0.0132 | 0.0132 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0062 | 0.1133 | 0.1076 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0218 | 0.7835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1133 | 0.1133 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0599 | 0.0599 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.9007 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.9007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.9007 | 0.9007 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0245 | 0.9007 | 0.9007 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.072 | 0.072 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0039 | 0.0132 | 0.0132 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0039 | 0.0132 | 0.5 |
Onchocerca volvulus | 0.005 | 0.0599 | 0.0364 | |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0325 | 0.0325 |
Brugia malayi | hypothetical protein | 0.0044 | 0.0325 | 0.0325 |
Echinococcus granulosus | caspase 2 | 0.0062 | 0.1133 | 0.1127 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0599 | 0.0599 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0132 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0062 | 0.1133 | 0.1127 |
Trichomonas vaginalis | glutaminase, putative | 0.0268 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0039 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.072 | 0.072 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0039 | 0.0132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0325 | 0.0325 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0039 | 0.0132 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0044 | 0.0325 | 0.0217 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.072 | 0.072 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.072 | 0.072 |
Brugia malayi | Cell death protein 3 precursor | 0.0062 | 0.1133 | 0.1133 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0039 | 0.0132 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0599 | 0.0599 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0062 | 0.1133 | 0.1133 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 45 nM | Ligand-dependent recruitment of steroid receptor coactivator 1 (SRC1) to Liver X receptor-alpha | ChEMBL. | 11985463 |
EC50 (binding) | = 45 nM | Ligand-dependent recruitment of steroid receptor coactivator 1 (SRC1) to Liver X receptor-alpha | ChEMBL. | 11985463 |
EC50 (binding) | = 425 nM | Effective concentration in LXR alpha-Gal4 receptor gene assay | ChEMBL. | 11985463 |
EC50 (binding) | = 425 nM | Effective concentration in LXR alpha-Gal4 receptor gene assay | ChEMBL. | 11985463 |
RE (functional) | = 1.1 | Relative efficacy compared to 24(S),25-epoxy cholesterol in Liver X receptor-alpha ligand-sensing assay | ChEMBL. | 11985463 |
RE (functional) | = 1.5 | Relative efficacy compared to 24(S),25-epoxy cholesterol in LXR alpha-Gal4 receptor gene assay | ChEMBL. | 11985463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.