Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.7371 | 0.7371 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0.6218 | 0.6188 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.7371 | 0.7371 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0158 | 0.7371 | 0.735 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0184 | 0.9921 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0146 | 0.6249 | 0.6219 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0184 | 1 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0184 | 0.9921 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0146 | 0.6249 | 0.6219 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0184 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0146 | 0.6249 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0146 | 0.6249 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0146 | 0.6249 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.6218 | 0.6218 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0146 | 0.6249 | 0.6219 |
Schistosoma mansoni | protein kinase | 0.0184 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0146 | 0.6249 | 0.6219 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0146 | 0.6249 | 0.6219 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0146 | 0.6218 | 0.6188 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0146 | 0.6249 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0146 | 0.6249 | 0.6219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.