Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.3387 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.3387 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.3387 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3387 | 0.3387 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3387 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.3387 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3387 | 0.3387 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.3387 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.3387 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.3387 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.9362 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.