Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0117 | 0.0247 | 0.0248 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0396 | 0.2209 | 0.2209 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0396 | 0.2209 | 0.347 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0149 | 0.0471 | 0.0616 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0961 | 0.6185 | 0.6185 |
Echinococcus granulosus | carboxylesterase 5A | 0.0149 | 0.0471 | 0.0616 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0396 | 0.2209 | 0.347 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0345 | 0.1849 | 0.2879 |
Echinococcus multilocularis | protein dispatched 1 | 0.0396 | 0.2209 | 0.347 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0961 | 0.6185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0338 | 0.0397 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0451 | 0.2597 | 1 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0345 | 0.1849 | 0.2879 |
Schistosoma mansoni | patched 1 | 0.0396 | 0.2209 | 0.2209 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0294 | 0.1495 | 0.1979 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0837 | 0.5316 | 0.8466 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0149 | 0.0471 | 0.0616 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0405 | 0.0115 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0396 | 0.2209 | 0.347 |
Echinococcus multilocularis | prolyl endopeptidase | 0.013 | 0.0338 | 0.0397 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0396 | 0.2209 | 0.347 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.013 | 0.0338 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 0.0471 | 0.0616 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.0516 | 0.0539 |
Echinococcus granulosus | prolyl endopeptidase | 0.013 | 0.0338 | 0.0397 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0961 | 0.6185 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0451 | 0.2597 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0149 | 0.0471 | 0.0616 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0177 | 0.0669 | 0.027 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.0405 | 0.0115 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0961 | 0.6185 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0961 | 0.6185 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0961 | 0.6185 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0451 | 0.2597 | 0.5 |
Toxoplasma gondii | MAPEG family protein | 0.0345 | 0.1849 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.013 | 0.0338 | 0.0338 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.1495 | 0.1979 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0149 | 0.0471 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0471 | 0.0616 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0405 | 0.0115 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.0247 | 0.0247 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 0.0471 | 0.0616 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0396 | 0.2209 | 0.347 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0451 | 0.2597 | 1 |
Schistosoma mansoni | peroxidasin | 0.0095 | 0.0096 | 0.0096 |
Echinococcus multilocularis | protein patched | 0.0396 | 0.2209 | 0.347 |
Brugia malayi | Carboxylesterase family protein | 0.0149 | 0.0471 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0471 | 0.0616 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0961 | 0.6185 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0396 | 0.2209 | 0.347 |
Loa Loa (eye worm) | carboxylesterase | 0.0149 | 0.0471 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.0961 | 0.6185 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0149 | 0.0471 | 0.0616 |
Brugia malayi | Carboxylesterase family protein | 0.0149 | 0.0471 | 0.0616 |
Schistosoma mansoni | peroxidasin | 0.0095 | 0.0096 | 0.0096 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0117 | 0.0247 | 0.0248 |
Brugia malayi | prolyl oligopeptidase family protein | 0.013 | 0.0338 | 0.0397 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.1495 | 0.1979 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0837 | 0.5316 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0294 | 0.1495 | 0.1979 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0345 | 0.1849 | 0.1849 |
Brugia malayi | CHE-14 protein | 0.0396 | 0.2209 | 0.347 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0177 | 0.0669 | 0.0841 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0961 | 0.6185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.2209 | 0.347 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0961 | 0.6185 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.013 | 0.0338 | 0.0338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.