Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0457 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0328 | 0.5651 | 0.5192 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0457 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0457 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0404 | 0.8199 | 0.8009 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0188 | 0.0955 | 0.0955 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0404 | 0.8199 | 0.8009 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0275 | 0.3862 | 0.3213 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0457 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0215 | 0.1839 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0215 | 0.1839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.8199 | 0.8009 |
Schistosoma mansoni | patched 1 | 0.0188 | 0.0955 | 0.0955 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0457 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0215 | 0.1839 | 1 |
Brugia malayi | CHE-14 protein | 0.0188 | 0.0955 | 0.0955 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0275 | 0.3862 | 0.3213 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0457 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0457 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0275 | 0.3862 | 0.3862 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0457 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0215 | 0.1839 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0297 | 0.4615 | 0.4615 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0328 | 0.5651 | 0.5651 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0373 | 0.7162 | 0.7162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.