Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0444 | 0.4291 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.012 | 0.0741 | 0.0668 |
Onchocerca volvulus | 0.0468 | 0.4559 | 1 | |
Brugia malayi | jmjC domain containing protein | 0.0104 | 0.057 | 0.1317 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0965 | 1 | 1 |
Echinococcus multilocularis | peregrin | 0.0086 | 0.0372 | 0.0297 |
Echinococcus granulosus | jun protein | 0.009 | 0.0421 | 0.0369 |
Brugia malayi | Pre-SET motif family protein | 0.0059 | 0.0078 | 0.0167 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0278 | 0.2471 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1979 | 0.1974 |
Onchocerca volvulus | 0.0082 | 0.0325 | 0.0516 | |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0327 | 0.0321 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0082 | 0.0327 | 0.0251 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.0341 | 0.0553 |
Plasmodium falciparum | phd finger protein, putative | 0.0086 | 0.0372 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0266 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0086 | 0.0372 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0266 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0269 | 0.2376 | 0.2371 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0059 | 0.0078 | 0.0024 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0266 | 0.0213 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0138 | 0.094 | 0.0869 |
Brugia malayi | jmjC domain containing protein | 0.0281 | 0.2512 | 0.585 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0266 | 0.026 |
Plasmodium vivax | hypothetical protein, conserved | 0.0086 | 0.0372 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0077 | 0.0277 | 0.0632 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0372 | 0.0297 |
Onchocerca volvulus | 0.0082 | 0.0327 | 0.0521 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0138 | 0.094 | 0.1618 |
Schistosoma mansoni | jumonji domain containing protein | 0.0224 | 0.1879 | 0.1816 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0278 | 0.2471 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.1001 | 0.3643 |
Echinococcus multilocularis | chromobox protein 1 | 0.0138 | 0.094 | 0.0869 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.3056 | 0.3002 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0266 | 0.6387 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0083 | 0.0341 | 0.0553 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0138 | 0.094 | 0.0869 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0266 | 0.6387 |
Brugia malayi | PHD-finger family protein | 0.0086 | 0.0372 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1044 | 0.1039 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0278 | 0.2471 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0281 | 0.2512 | 0.2472 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0208 | 0.0472 |
Echinococcus multilocularis | geminin | 0.0331 | 0.3056 | 0.3002 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0372 | 0.0366 |
Echinococcus granulosus | jumonji domain containing protein | 0.012 | 0.0741 | 0.069 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0077 | 0.0277 | 0.0409 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.1979 | 0.1916 |
Trichomonas vaginalis | chromobox protein, putative | 0.0138 | 0.094 | 0.1618 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0082 | 0.0327 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0078 | 0.0072 |
Trichomonas vaginalis | chromobox protein, putative | 0.0083 | 0.0341 | 0.0553 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0965 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0394 | 0.0388 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.3056 | 0.3002 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.0421 | 0.0968 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0082 | 0.0327 | 0.0251 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0082 | 0.0327 | 0.0749 |
Brugia malayi | hypothetical protein | 0.0233 | 0.1979 | 0.4604 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.1979 | 0.1935 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0412 | 0.3937 | 0.3933 |
Schistosoma mansoni | lipoxygenase | 0.0127 | 0.0821 | 0.0749 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0266 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0266 | 0.019 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0235 | 0.0159 |
Brugia malayi | Pre-SET motif family protein | 0.0412 | 0.3937 | 0.9174 |
Trichomonas vaginalis | glutaminase, putative | 0.0269 | 0.2376 | 0.4172 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0104 | 0.057 | 0.0564 |
Echinococcus granulosus | geminin | 0.0331 | 0.3056 | 0.3018 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.2747 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0086 | 0.0372 | 0.0366 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.0277 | 0.0439 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.0277 | 0.0439 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.009 | 0.0421 | 0.0345 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0086 | 0.0372 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0095 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0277 | 0.0271 |
Brugia malayi | Dopamine receptor protein 1 | 0.0439 | 0.4235 | 0.987 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0086 | 0.0372 | 0.032 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0086 | 0.0372 | 0.0297 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0104 | 0.057 | 0.0496 |
Echinococcus multilocularis | jun protein | 0.009 | 0.0421 | 0.0345 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0082 | 0.0325 | 0.0249 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0127 | 0.0821 | 0.0749 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0138 | 0.094 | 0.2179 |
Schistosoma mansoni | lipoxygenase | 0.0089 | 0.0403 | 0.0327 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0266 | 0.019 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.4235 | 0.4231 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.2747 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0086 | 0.0372 | 0.0622 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0104 | 0.057 | 0.0519 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0104 | 0.057 | 0.0496 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0177 | 0.1374 | 0.1369 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0127 | 0.0821 | 0.0771 |
Schistosoma mansoni | glutaminase | 0.0269 | 0.2376 | 0.2316 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.2747 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0269 | 0.2376 | 0.957 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.0372 | 0.0855 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.009 | 0.0421 | 0.0369 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0568 | 0.5653 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.016 | 0.1178 | 0.4137 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0568 | 0.5653 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0269 | 0.2376 | 0.5531 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0266 | 0.6387 |
Echinococcus granulosus | chromobox protein 1 | 0.0138 | 0.094 | 0.0891 |
Echinococcus granulosus | chromobox protein 1 | 0.0138 | 0.094 | 0.0891 |
Loa Loa (eye worm) | glutaminase | 0.0269 | 0.2376 | 0.2371 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0138 | 0.094 | 0.0934 |
Trichomonas vaginalis | set domain proteins, putative | 0.0468 | 0.4559 | 0.8054 |
Onchocerca volvulus | 0.0071 | 0.0208 | 0.0255 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0104 | 0.057 | 0.0496 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Schistosoma mansoni | jun-related protein | 0.0073 | 0.0235 | 0.0159 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0266 | 0.0606 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0965 | 1 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0086 | 0.0372 | 0.0297 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.2747 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0568 | 0.5653 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0281 | 0.2512 | 0.2454 |
Schistosoma mansoni | chromobox protein | 0.0138 | 0.094 | 0.0869 |
Echinococcus granulosus | peregrin | 0.0086 | 0.0372 | 0.032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.