Detailed information for compound 891038

Basic information

Technical information
  • TDR Targets ID: 891038
  • Name: 6-[(2-methoxyphenyl)carbamoyl]bicyclo[2.2.1]h eptane-5-carboxylic acid
  • MW: 289.326 | Formula: C16H19NO4
  • H donors: 2 H acceptors: 3 LogP: 2.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)C1C2CCC(C1C(=O)O)C2
  • InChi: 1S/C16H19NO4/c1-21-12-5-3-2-4-11(12)17-15(18)13-9-6-7-10(8-9)14(13)16(19)20/h2-5,9-10,13-14H,6-8H2,1H3,(H,17,18)(H,19,20)
  • InChiKey: YOSJNPWFOUPEQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2-methoxyphenyl)carbamoyl]norbornane-2-carboxylic acid
  • 3-[[(2-methoxyphenyl)amino]-oxomethyl]-2-norbornanecarboxylic acid
  • IVK/0012939
  • Oprea1_204239

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Loa Loa (eye worm) hypothetical protein 0.008 0.3998 0.3998
Brugia malayi Cytochrome P450 family protein 0.0053 0.1681 0.1321
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0072 0.3278 0.277
Loa Loa (eye worm) nuclear hormone receptor 0.0072 0.3278 0.3278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0152 1 1
Brugia malayi nuclear hormone receptor 0.0072 0.3278 0.2988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.008 0.3998 0.3739
Echinococcus multilocularis ecdysone induced protein 78C 0.0152 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0072 0.3278 0.3278
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0208 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0152 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.3998 0.3544
Onchocerca volvulus 0.0152 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0072 0.3278 0.3278
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0152 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0152 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.3998 0.3739
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.3998 0.3739
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0072 0.3278 0.2988
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0072 0.3278 0.2988
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0152 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0152 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0152 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0152 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0152 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0072 0.3278 0.2988
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0152 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0152 1 1
Brugia malayi ecdysone receptor 0.0072 0.3278 0.2988
Brugia malayi nuclear receptor NHR-88 0.0152 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0072 0.3278 0.2988
Schistosoma mansoni steroid hormone receptor ad4bp 0.0152 1 1
Schistosoma mansoni nuclear hormone receptor 0.0072 0.3278 0.277
Brugia malayi nuclear hormone receptor family member odr-7 0.0072 0.3278 0.2988
Loa Loa (eye worm) hypothetical protein 0.008 0.3998 0.3998
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.3998 0.3998
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0152 1 1
Schistosoma mansoni coup transcription factor 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0152 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0152 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0152 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0072 0.3278 0.2988
Brugia malayi photoreceptor-specific nuclear receptor 0.0152 1 1
Brugia malayi steroid hormone receptor 0.0152 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0152 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0072 0.3278 0.2988
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0208 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0152 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0152 1 1
Brugia malayi hypothetical protein 0.008 0.3998 0.3739
Loa Loa (eye worm) DR-78 0.0072 0.3278 0.3278
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0152 1 1
Echinococcus granulosus FTZ F1 alpha 0.0152 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0152 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0072 0.3278 0.2988
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Brugia malayi tailless protein 0.0072 0.3278 0.2988
Brugia malayi nuclear receptor NHR-88 0.0072 0.3278 0.2988
Brugia malayi Nuclear hormone receptor E75 0.0072 0.3278 0.2988
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.1681 0.1681
Brugia malayi nuclear receptor NHR-67 0.0072 0.3278 0.2988
Schistosoma mansoni zinc finger protein 0.0072 0.3278 0.277
Brugia malayi hypothetical protein 0.0072 0.3278 0.2988
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0152 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0152 1 1
Brugia malayi conserved hypotetical protein 0.0072 0.3278 0.2988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0152 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0072 0.3278 0.277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Echinococcus multilocularis nuclear receptor nhr 48 0.0072 0.3278 0.2988
Loa Loa (eye worm) hypothetical protein 0.008 0.3998 0.3998
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0152 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0072 0.3278 0.2988
Brugia malayi nuclear receptor RXR 0.0072 0.3278 0.2988
Brugia malayi orphan nuclear receptor NR2E1 0.0072 0.3278 0.2988
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.008 0.3998 0.3998
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0152 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0152 1 1
Schistosoma mansoni nuclear hormone receptor 0.0072 0.3278 0.277
Echinococcus granulosus Nuclear hormone receptor HR96 0.0072 0.3278 0.2988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.3278 0.2988
Brugia malayi nuclear receptor RXR 0.008 0.3998 0.3739
Brugia malayi hypothetical protein 0.0072 0.3278 0.2988
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Schistosoma mansoni nuclear hormone receptor 0.0152 1 1
Schistosoma mansoni thyroid hormone receptor 0.0152 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0152 1 1
Schistosoma mansoni thyroid hormone receptor 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Schistosoma mansoni nuclear receptor 0.0072 0.3278 0.277
Brugia malayi Nuclear hormone receptor E75 0.0072 0.3278 0.2988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0152 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.008 0.3998 0.3544
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.008 0.3998 0.3739
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Schistosoma mansoni RAR-like nuclear receptor 0.0152 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0072 0.3278 0.2988
Brugia malayi Nuclear hormone receptor-like 1 0.0152 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0152 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Schistosoma mansoni nuclear receptor 0.0072 0.3278 0.277
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0152 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0152 1 1
Brugia malayi hypothetical protein 0.008 0.3998 0.3739
Schistosoma mansoni nuclear receptor nhr-48 0.0072 0.3278 0.277
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0152 1 1
Brugia malayi nuclear hormone receptor 0.0152 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0152 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.3998 0.3998
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0152 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0072 0.3278 0.2988
Loa Loa (eye worm) hypothetical protein 0.0072 0.3278 0.3278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.3278 0.2988
Echinococcus granulosus ecdysone induced protein 78C 0.0152 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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