Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4147 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1947 | 0.1947 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1947 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.4147 | 0.3787 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4147 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.058 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4147 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.058 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.058 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.058 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.058 | 0.058 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1947 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1947 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1947 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.732 | 0.732 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1947 | 0.1452 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1947 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.058 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.732 | 0.7155 |
Brugia malayi | hypothetical protein | 0.0035 | 0.4147 | 0.4147 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.732 | 0.7155 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.058 | 0.058 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3882 | 0.3505 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.4147 | 0.3787 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.058 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4147 | 0.3787 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3882 | 0.3505 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.732 | 0.732 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1947 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.058 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1947 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.4147 | 0.3787 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.3882 | 0.3882 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1947 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.