Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0869 | 0.5726 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0112 | 0.0594 | 0.063 |
Echinococcus multilocularis | methionine synthase reductase | 0.0536 | 0.3472 | 0.336 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0112 | 0.0594 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0112 | 0.0594 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0332 | 0.2088 | 0.3194 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0099 | 0.0504 | 0.034 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0869 | 0.5726 | 1 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0099 | 0.0504 | 0.034 |
Trypanosoma brucei | oligopeptidase b | 0.0112 | 0.0594 | 0.0172 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0112 | 0.0594 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.038 | 0.0404 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0869 | 0.5726 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0099 | 0.0504 | 0.034 |
Trypanosoma cruzi | reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0869 | 0.5726 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0332 | 0.2088 | 0.3033 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0081 | 0.038 | 0.0214 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.017 | 0.018 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0073 | 0.033 | 0.0163 |
Leishmania major | p450 reductase, putative | 0.0869 | 0.5726 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1413 | 0.9419 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1413 | 0.9419 | 0.9409 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1413 | 0.9419 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0265 | 0.0281 |
Trypanosoma brucei | prolyl endopeptidase | 0.0112 | 0.0594 | 0.0172 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0869 | 0.5726 | 0.5653 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0112 | 0.0594 | 0.063 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Loa Loa (eye worm) | diaphorase | 0.0099 | 0.0504 | 0.0535 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0332 | 0.2088 | 0.3298 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0112 | 0.0594 | 0.0172 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0112 | 0.0594 | 0.125 |
Brugia malayi | diaphorase | 0.0099 | 0.0504 | 0.0535 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0081 | 0.038 | 0.0404 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0332 | 0.2088 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0869 | 0.5726 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0332 | 0.2088 | 0.3194 |
Brugia malayi | flavodoxin family protein | 0.0332 | 0.2088 | 0.2217 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0112 | 0.0594 | 0.0399 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0081 | 0.038 | 0.0152 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0112 | 0.0594 | 0.125 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0112 | 0.0594 | 0.125 |
Chlamydia trachomatis | sulfite reductase | 0.0536 | 0.3472 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0869 | 0.5726 | 1 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0081 | 0.038 | 0.0214 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0332 | 0.2088 | 0.3194 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0073 | 0.033 | 0.035 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0332 | 0.2088 | 0.3033 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0112 | 0.0594 | 0.0546 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0475 | 0.3057 | 0.2937 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0332 | 0.2088 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.2297 | 0.2438 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0332 | 0.2088 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0112 | 0.0594 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0869 | 0.5726 | 0.6079 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0869 | 0.5726 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0475 | 0.3057 | 0.2937 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0081 | 0.038 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.038 | 0.0404 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0869 | 0.5726 | 0.6079 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0099 | 0.0504 | 0.0231 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0112 | 0.0594 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.038 | 0.0404 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0536 | 0.3472 | 0.3686 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0099 | 0.0504 | 0.0462 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0099 | 0.0504 | 0.034 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0332 | 0.2088 | 0.3033 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0438 | 0.2803 | 0.2678 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0431 | 0.2758 | 0.2633 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0536 | 0.3472 | 0.336 |
Echinococcus granulosus | methionine synthase reductase | 0.0536 | 0.3472 | 0.336 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0475 | 0.3057 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0112 | 0.0594 | 0.0797 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1413 | 0.9419 | 0.9409 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0332 | 0.2088 | 0.2217 |
Leishmania major | cytochrome P450 reductase, putative | 0.077 | 0.5057 | 0.8717 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0112 | 0.0594 | 0.125 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0869 | 0.5726 | 0.5653 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0112 | 0.0594 | 0.0431 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1413 | 0.9419 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Brugia malayi | FAD binding domain containing protein | 0.0869 | 0.5726 | 0.6079 |
Plasmodium vivax | hypothetical protein, conserved | 0.0112 | 0.0594 | 0.0172 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0112 | 0.0594 | 0.0172 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0869 | 0.5726 | 0.5653 |
Brugia malayi | flavodoxin family protein | 0.0869 | 0.5726 | 0.6079 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0869 | 0.5726 | 1 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0099 | 0.0504 | 0.0462 |
Plasmodium falciparum | peptidase, putative | 0.0112 | 0.0594 | 0.0172 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0332 | 0.2088 | 0.3298 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0099 | 0.0504 | 0.0535 |
Giardia lamblia | Hypothetical protein | 0.077 | 0.5057 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0475 | 0.3057 | 0.4888 |
Onchocerca volvulus | 0.0099 | 0.0504 | 0.0137 | |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.1499 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0112 | 0.0594 | 0.063 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0332 | 0.2088 | 0.3298 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0112 | 0.0594 | 0.0456 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0869 | 0.5726 | 0.5653 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0332 | 0.2088 | 0.3033 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Trypanosoma cruzi | p450 reductase, putative | 0.0869 | 0.5726 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0332 | 0.2088 | 0.3033 |
Echinococcus granulosus | prolyl endopeptidase | 0.0112 | 0.0594 | 0.0431 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0112 | 0.0594 | 0.0431 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0112 | 0.0594 | 0.0172 |
Toxoplasma gondii | hypothetical protein | 0.0112 | 0.0594 | 0.0797 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0112 | 0.0594 | 0.0399 |
Trypanosoma cruzi | oligopeptidase b | 0.0112 | 0.0594 | 0.0399 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0112 | 0.0594 | 0.0399 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Trypanosoma cruzi | p450 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0112 | 0.0594 | 0.0399 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0431 | 0.2758 | 0.8883 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.038 | 0.0404 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1413 | 0.9419 | 0.9409 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0594 | 0.063 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0081 | 0.038 | 0.0404 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0112 | 0.0594 | 0.0172 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0081 | 0.038 | 0.0214 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0073 | 0.033 | 0.035 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0099 | 0.0504 | 0.0231 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Brugia malayi | FAD binding domain containing protein | 0.0536 | 0.3472 | 0.3686 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0431 | 0.2758 | 0.8883 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0475 | 0.3057 | 0.5006 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0112 | 0.0594 | 0.0546 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0112 | 0.0594 | 0.0431 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0112 | 0.0594 | 0.125 |
Trypanosoma cruzi | oligopeptidase b | 0.0112 | 0.0594 | 0.0399 |
Plasmodium vivax | flavodoxin domain containing protein | 0.077 | 0.5057 | 0.8717 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0081 | 0.038 | 0.0404 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0112 | 0.0594 | 0.0172 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0332 | 0.2088 | 1 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0073 | 0.033 | 0.0163 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0099 | 0.0504 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0594 | 0.0546 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0112 | 0.0594 | 0.0797 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Giardia lamblia | Flavohemoprotein lateral transfer candidate | 0.0099 | 0.0504 | 0.0264 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0869 | 0.5726 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.0376 | 0.0209 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0112 | 0.0594 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0594 | 0.063 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.017 | 0.018 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0869 | 0.5726 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.077 | 0.5057 | 0.8766 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0475 | 0.3057 | 0.5006 |
Brugia malayi | hypothetical protein | 0.0363 | 0.2297 | 0.2438 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0869 | 0.5726 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0099 | 0.0504 | 0.034 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0112 | 0.0594 | 0.063 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Schistosoma mansoni | cytochrome B5 | 0.0099 | 0.0504 | 0.034 |
Schistosoma mansoni | voltage-gated potassium channel | 0.008 | 0.0376 | 0.0209 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.077 | 0.5057 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0869 | 0.5726 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0099 | 0.0504 | 0.0231 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0475 | 0.3057 | 0.4888 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Leishmania major | oligopeptidase b | 0.0112 | 0.0594 | 0.0172 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0594 | 0.063 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0332 | 0.2088 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0475 | 0.3057 | 0.3245 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.1499 | 1 | 1 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0081 | 0.038 | 0.0152 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0112 | 0.0594 | 0.0431 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0081 | 0.038 | 0.0152 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0112 | 0.0594 | 0.0172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.038 | 0.0152 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0112 | 0.0594 | 0.125 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0332 | 0.2088 | 0.3298 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0475 | 0.3057 | 0.2937 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0112 | 0.0594 | 0.0236 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0475 | 0.3057 | 0.4888 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0112 | 0.0594 | 1 |
Treponema pallidum | flavodoxin | 0.0332 | 0.2088 | 1 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0099 | 0.0504 | 0.0535 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0869 | 0.5726 | 0.5653 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.038 | 0.0152 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0112 | 0.0594 | 0.0431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.96 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | = 1.73 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 102.4 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 102.5 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.