Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.032 | 0.7817 | 0.7817 |
Echinococcus multilocularis | cyclin B3 1 | 0.0232 | 0.5203 | 0.5203 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0373 | 0.9393 | 0.9393 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0122 | 0.1968 | 0.1968 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0287 | 0.683 | 0.683 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0373 | 0.9393 | 0.9393 |
Entamoeba histolytica | protein kinase , putative | 0.0373 | 0.9393 | 0.9393 |
Brugia malayi | Protein kinase domain containing protein | 0.0287 | 0.683 | 0.683 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0287 | 0.683 | 0.683 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0287 | 0.683 | 0.683 |
Leishmania major | hypothetical protein, conserved | 0.0122 | 0.1968 | 0.1968 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0287 | 0.683 | 0.683 |
Schistosoma mansoni | cyclin B | 0.0394 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 0.0115 | 0.0115 |
Brugia malayi | cell division control protein 2 homolog | 0.0287 | 0.683 | 0.683 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0287 | 0.683 | 0.683 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Leishmania major | p450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0373 | 0.9393 | 0.9393 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0122 | 0.1968 | 0.1968 |
Brugia malayi | flavodoxin family protein | 0.0122 | 0.1968 | 0.1968 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0122 | 0.1968 | 0.1968 |
Toxoplasma gondii | aurora kinase | 0.0373 | 0.9393 | 1 |
Echinococcus granulosus | cyclins | 0.0232 | 0.5203 | 0.5203 |
Echinococcus granulosus | cyclin b3 | 0.0232 | 0.5203 | 0.5203 |
Schistosoma mansoni | protein kinase | 0.0373 | 0.9393 | 0.9393 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0122 | 0.1968 | 0.1968 |
Giardia lamblia | Aurora kinase | 0.0373 | 0.9393 | 0.9393 |
Schistosoma mansoni | cyclin B3 | 0.0232 | 0.5203 | 0.5203 |
Trichomonas vaginalis | cyclin B, putative | 0.0394 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0232 | 0.5203 | 0.5203 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0161 | 0.3117 | 0.3117 |
Echinococcus multilocularis | cyclin B | 0.0394 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0287 | 0.683 | 0.7271 |
Entamoeba histolytica | cyclin family protein | 0.0232 | 0.5203 | 0.5203 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.032 | 0.7817 | 0.7817 |
Brugia malayi | serine/threonine kinase 12 | 0.0373 | 0.9393 | 0.9393 |
Trichomonas vaginalis | AGC family protein kinase | 0.0373 | 0.9393 | 0.9393 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0232 | 0.5203 | 0.5203 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0287 | 0.683 | 0.683 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0198 | 0.4194 | 0.4194 |
Echinococcus multilocularis | cyclin b3 | 0.0232 | 0.5203 | 0.5203 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0394 | 1 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0122 | 0.1968 | 0.2096 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0287 | 0.683 | 0.683 |
Trichomonas vaginalis | cyclin D, putative | 0.0232 | 0.5203 | 0.5203 |
Leishmania major | cytochrome P450 reductase, putative | 0.0284 | 0.674 | 0.674 |
Entamoeba histolytica | cyclin family protein | 0.0232 | 0.5203 | 0.5203 |
Giardia lamblia | Kinase, CMGC CDK | 0.0287 | 0.683 | 0.683 |
Loa Loa (eye worm) | AUR protein kinase | 0.0373 | 0.9393 | 0.9393 |
Entamoeba histolytica | protein kinase, putative | 0.0373 | 0.9393 | 0.9393 |
Trichomonas vaginalis | cyclins, putative | 0.0232 | 0.5203 | 0.5203 |
Loa Loa (eye worm) | AUR protein kinase | 0.0373 | 0.9393 | 0.9393 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.683 | 0.683 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0287 | 0.683 | 0.683 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0373 | 0.9393 | 0.9393 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0122 | 0.1968 | 0.1968 |
Trichomonas vaginalis | cyclins, putative | 0.0218 | 0.4797 | 0.4797 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0122 | 0.1968 | 0.2096 |
Schistosoma mansoni | cytochrome P450 reductase | 0.032 | 0.7817 | 0.7817 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0122 | 0.1968 | 0.1968 |
Giardia lamblia | Hypothetical protein | 0.0284 | 0.674 | 0.674 |
Echinococcus granulosus | cyclins | 0.0232 | 0.5203 | 0.5203 |
Giardia lamblia | Cyclin A | 0.0232 | 0.5203 | 0.5203 |
Brugia malayi | FAD binding domain containing protein | 0.0198 | 0.4194 | 0.4194 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0287 | 0.683 | 0.683 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0284 | 0.674 | 0.674 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0287 | 0.683 | 0.683 |
Giardia lamblia | Kinase, CMGC CDK | 0.0287 | 0.683 | 0.683 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0287 | 0.683 | 0.683 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0287 | 0.683 | 0.7271 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.683 | 0.683 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0122 | 0.1968 | 0.1968 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0287 | 0.683 | 0.683 |
Trypanosoma cruzi | p450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0159 | 0.3045 | 0.3045 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0122 | 0.1968 | 0.1968 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0394 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.032 | 0.7817 | 0.7817 |
Trichomonas vaginalis | cyclins, putative | 0.0394 | 1 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0373 | 0.9393 | 0.9393 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Trichomonas vaginalis | cyclin D, putative | 0.0232 | 0.5203 | 0.5203 |
Trichomonas vaginalis | AGC family protein kinase | 0.0373 | 0.9393 | 0.9393 |
Plasmodium falciparum | cyclin | 0.0232 | 0.5203 | 0.5539 |
Trichomonas vaginalis | sulfite reductase, putative | 0.032 | 0.7817 | 0.7817 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0287 | 0.683 | 0.683 |
Entamoeba histolytica | cyclin, putative | 0.0394 | 1 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0394 | 1 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0232 | 0.5203 | 0.5203 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.6592 | 0.6592 |
Trichomonas vaginalis | cyclin B, putative | 0.0394 | 1 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0232 | 0.5203 | 0.5203 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.032 | 0.7817 | 0.7817 |
Trichomonas vaginalis | cyclin B, putative | 0.0232 | 0.5203 | 0.5203 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0394 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0287 | 0.683 | 0.683 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0373 | 0.9393 | 0.9393 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0287 | 0.683 | 0.683 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0373 | 0.9393 | 1 |
Leishmania major | cyclin | 0.0394 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0232 | 0.5203 | 0.5203 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0373 | 0.9393 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0232 | 0.5203 | 0.5203 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0373 | 0.9393 | 0.9393 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0394 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3142 | 0.3142 |
Echinococcus granulosus | aurora kinase A | 0.0373 | 0.9393 | 0.9393 |
Entamoeba histolytica | protein kinase, putative | 0.0373 | 0.9393 | 0.9393 |
Trichomonas vaginalis | AGC family protein kinase | 0.0373 | 0.9393 | 0.9393 |
Chlamydia trachomatis | sulfite reductase | 0.0198 | 0.4194 | 0.5 |
Trypanosoma cruzi | cyclin 6, putative | 0.0394 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.032 | 0.7817 | 0.8323 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0287 | 0.683 | 0.683 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0159 | 0.3045 | 0.3242 |
Giardia lamblia | Hypothetical protein | 0.0232 | 0.5203 | 0.5203 |
Echinococcus granulosus | methionine synthase reductase | 0.0198 | 0.4194 | 0.4194 |
Trypanosoma brucei | aurora B kinase | 0.0373 | 0.9393 | 0.9393 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0122 | 0.1968 | 0.1968 |
Loa Loa (eye worm) | AUR protein kinase | 0.0373 | 0.9393 | 0.9393 |
Leishmania major | protein kinase, putative | 0.0373 | 0.9393 | 0.9393 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.032 | 0.7817 | 0.8323 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.7817 | 0.7817 |
Plasmodium vivax | hypothetical protein, conserved | 0.0122 | 0.1968 | 0.2096 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0287 | 0.683 | 0.683 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0373 | 0.9393 | 0.9393 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.032 | 0.7817 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.032 | 0.7817 | 0.7817 |
Trichomonas vaginalis | cyclins, putative | 0.0394 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0284 | 0.674 | 0.674 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0122 | 0.1968 | 0.1968 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0373 | 0.9393 | 0.9393 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0373 | 0.9393 | 0.9393 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0198 | 0.4194 | 0.4194 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.032 | 0.7817 | 0.7817 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0122 | 0.1968 | 0.1968 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0122 | 0.1968 | 0.1968 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0287 | 0.683 | 0.683 |
Toxoplasma gondii | hypothetical protein | 0.0176 | 0.3548 | 0.3777 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0287 | 0.683 | 0.683 |
Trypanosoma cruzi | cyclin, putative | 0.0394 | 1 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0232 | 0.5203 | 0.5203 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0122 | 0.1968 | 0.1968 |
Echinococcus granulosus | cyclin dependent kinase | 0.0287 | 0.683 | 0.683 |
Brugia malayi | FAD binding domain containing protein | 0.032 | 0.7817 | 0.7817 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.032 | 0.7817 | 0.7817 |
Trichomonas vaginalis | cyclin B, putative | 0.0394 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0287 | 0.683 | 0.683 |
Echinococcus granulosus | cyclins | 0.0232 | 0.5203 | 0.5203 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0122 | 0.1968 | 0.1968 |
Plasmodium falciparum | protein kinase 5 | 0.0287 | 0.683 | 0.7271 |
Brugia malayi | flavodoxin family protein | 0.032 | 0.7817 | 0.7817 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0287 | 0.683 | 0.683 |
Onchocerca volvulus | 0.0394 | 1 | 1 | |
Trichomonas vaginalis | cyclin B, putative | 0.0394 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0394 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0394 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0373 | 0.9393 | 0.9393 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0159 | 0.3045 | 0.3242 |
Echinococcus multilocularis | cyclins | 0.0232 | 0.5203 | 0.5203 |
Trichomonas vaginalis | cyclin A, putative | 0.0394 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0122 | 0.1968 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.032 | 0.7817 | 0.7817 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0287 | 0.683 | 0.683 |
Echinococcus multilocularis | methionine synthase reductase | 0.0198 | 0.4194 | 0.4194 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 0.0115 | 0.0115 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0287 | 0.683 | 0.683 |
Schistosoma mansoni | cyclins | 0.0232 | 0.5203 | 0.5203 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0232 | 0.5203 | 0.5203 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0284 | 0.674 | 0.7176 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.032 | 0.7817 | 0.7817 |
Echinococcus granulosus | cyclin B | 0.0394 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0232 | 0.5203 | 0.5203 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0373 | 0.9393 | 0.9393 |
Trichomonas vaginalis | cyclins, putative | 0.0394 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0232 | 0.5203 | 0.5203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.