Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.268 | 0.3578 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.1213 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0005 | 0.0071 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Schistosoma mansoni | cript-related | 0.0005 | 0.0071 | 0.0071 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.268 | 0.3578 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4688 | 0.6332 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.268 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4403 | 0.4403 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.268 | 0.5 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0956 | 0.1213 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0005 | 0.0071 | 0.0265 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.268 | 1 |
Schistosoma mansoni | carbon catabolite repressor protein | 0.0005 | 0.0071 | 0.0071 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.268 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.268 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0005 | 0.0071 | 0.0265 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0005 | 0.0071 | 0.0199 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0005 | 0.0071 | 0.0199 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.268 | 0.2966 |
Plasmodium falciparum | carbon catabolite repressor protein 4, putative | 0.0005 | 0.0071 | 0.0265 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0005 | 0.0071 | 0.0265 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.268 | 1 |
Entamoeba histolytica | inositol polyphosphate-5-phosphatase, putative | 0.0005 | 0.0071 | 0.0265 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.268 | 0.3578 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0796 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.1213 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0005 | 0.0071 | 0.0265 |
Onchocerca volvulus | 0.0035 | 0.4403 | 1 | |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0005 | 0.0071 | 0.0199 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0005 | 0.0071 | 0.0199 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4688 | 0.6332 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.268 | 1 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0005 | 0.0071 | 0.0071 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.268 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0651 | 0.0796 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0005 | 0.0071 | 0.0265 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0936 | 0.1186 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Entamoeba histolytica | sphingomyelinase C precursor, putative | 0.0005 | 0.0071 | 0.0265 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0005 | 0.0071 | 0.0199 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0005 | 0.0071 | 0.0199 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0005 | 0.0071 | 0.0199 |
Plasmodium falciparum | carbon catabolite repressor protein 4, putative | 0.0005 | 0.0071 | 0.0265 |
Plasmodium falciparum | exodeoxyribonuclease III, putative | 0.0005 | 0.0071 | 0.0265 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.268 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.268 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8869 | 1 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase family protein | 0.0005 | 0.0071 | 0.0265 |
Schistosoma mansoni | ocrl type II inositol 5-phosphatase | 0.0005 | 0.0071 | 0.0071 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.268 | 0.268 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.268 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0796 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.268 | 0.268 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.5942 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.268 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.5942 |
Plasmodium falciparum | endonuclease/exonuclease/phosphatase family protein, putative | 0.0005 | 0.0071 | 0.0265 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase domain containing protein | 0.0005 | 0.0071 | 0.0265 |
Entamoeba histolytica | inositol polyphosphate 5-phosphatase, putative | 0.0005 | 0.0071 | 0.0265 |
Schistosoma mansoni | hypothetical protein | 0.0005 | 0.0071 | 0.0071 |
Schistosoma mansoni | synaptojanin | 0.0005 | 0.0071 | 0.0071 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 0.1969 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.1969 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0651 | 0.0796 |
Schistosoma mansoni | nocturnin | 0.0005 | 0.0071 | 0.0071 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.268 | 0.3578 |
Schistosoma mansoni | synaptojanin | 0.0005 | 0.0071 | 0.0071 |
Entamoeba histolytica | endonuclease/exonuclease/phosphatase domain containing protein | 0.0005 | 0.0071 | 0.0265 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7362 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7362 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.1969 |
Plasmodium falciparum | DNase I-like protein, putative | 0.0005 | 0.0071 | 0.0265 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0005 | 0.0071 | 0.0199 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.268 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.268 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.