TDR Targets

Basic information

Technical information

TDR Targets ID: 89186
Name: ethyl 2-[2-amino-3-(4-chlorobenzoyl)-5,7-dihy dro-4H-thieno[2,3-c]pyridin-6-yl]acetate
MW: 378.873 | Formula: C18H19ClN2O3S
H donors: 1 H acceptors: 2 LogP: 3.97 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CN1CCc2c(C1)sc(c2C(=O)c1ccc(cc1)Cl)N
InChi: 1S/C18H19ClN2O3S/c1-2-24-15(22)10-21-8-7-13-14(9-21)25-18(20)16(13)17(23)11-3-5-12(19)6-4-11/h3-6H,2,7-10,20H2,1H3
InChiKey: MFBXKDKZGFIBNE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-amino-3-[(4-chlorophenyl)-oxomethyl]-5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl]acetic acid ethyl ester
ethyl 2-[2-azanyl-3-(4-chlorophenyl)carbonyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl]ethanoate
2-[2-amino-3-(4-chlorobenzoyl)-5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl]acetic acid ethyl ester
ethyl 2-[2-amino-3-(4-chlorobenzoyl)-5,7-dihydro-4H-thieno[5,4-c]pyridin-6-yl]acetate
2-[2-amino-3-[(4-chlorophenyl)-oxomethyl]-5,7-dihydro-4H-thieno[5,4-c]pyridin-6-yl]acetic acid ethyl ester
2-[2-amino-3-(4-chlorobenzoyl)-5,7-dihydro-4H-thieno[5,4-c]pyridin-6-yl]acetic acid ethyl ester
ethyl 2-[2-amino-3-(4-chlorophenyl)carbonyl-5,7-dihydro-4H-thieno[5,4-c]pyridin-6-yl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	aminopeptidase N	0.0106	0.2637	0.275
Loa Loa (eye worm)	inositol-1	0.0037	0.0647	0.0674
Brugia malayi	Peroxidasin	0.0162	0.4241	0.4241
Mycobacterium tuberculosis	Hypothetical protein	0.0074	0.1717	0.4145
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0646	0.1065
Loa Loa (eye worm)	glutamate receptor	0.0023	0.0232	0.0242
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0647	0.0006
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0058	0.1229	0.1229
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0029	0.0389	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0037	0.0646	0.1441
Onchocerca volvulus		0.0162	0.4241	0.4102
Loa Loa (eye worm)	animal heme peroxidase	0.0162	0.4241	0.4422
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0106	0.2637	0.6236
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0058	0.1229	0.1697
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0647	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0235	0.0245
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0235	0.0421
Schistosoma mansoni	metabotropic glutamate receptor	0.0029	0.0392	0.0867
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0029	0.0389	0.0405
Brugia malayi	Peptidase family M1 containing protein	0.0106	0.2637	0.2637
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0069	0.1557	0.1557
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0037	0.0646	0.0673
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0067	0.1492	0.3305
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0029	0.0389	0.0389
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0029	0.0389	0.0405
Brugia malayi	hypothetical protein	0.0106	0.2637	0.2637
Echinococcus multilocularis	peroxidasin	0.0162	0.4241	0.4241
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0235	0.0421
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0646	0.0645
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1652	0.1722
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0053	0.1101	0.1101
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0058	0.1229	0.1697
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0106	0.2637	0.5841
Onchocerca volvulus	Chorion peroxidase homolog	0.0162	0.4241	0.4102
Loa Loa (eye worm)	animal heme peroxidase	0.0162	0.4241	0.4422
Onchocerca volvulus		0.0162	0.4241	0.4102
Brugia malayi	Animal haem peroxidase family protein	0.0162	0.4241	0.4241
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0389	0.0388
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0037	0.0646	0.1441
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0235	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0066	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0029	0.0389	0.0388
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0037	0.0646	0.1429
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0389	0.0389
Loa Loa (eye worm)	TATA binding protein associated factor	0.0037	0.0646	0.0673
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Brugia malayi	ecdysteroid receptor	0.0347	0.9591	0.9591
Schistosoma mansoni	metabotropic glutamate receptor	0.0049	0.0985	0.2181
Loa Loa (eye worm)	blistered cuticle protein 3	0.0162	0.4241	0.4422
Mycobacterium ulcerans	thymidylate synthase	0.0157	0.4087	1
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0037	0.0646	0.1065
Loa Loa (eye worm)	prolyl oligopeptidase	0.0171	0.4514	0.4707
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0647	0.0004
Onchocerca volvulus	Protein ultraspiracle homolog	0.0029	0.0389	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Mycobacterium ulcerans	aminopeptidase N PepN	0.0037	0.0646	0.1441
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0157	0.4087	1
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0037	0.0646	0.0645
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0029	0.0389	0.0388
Onchocerca volvulus	Peroxidasin homolog	0.0162	0.4241	0.4102
Brugia malayi	metabotropic glutamate receptor type 2	0.0029	0.0392	0.0392
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0029	0.0389	0.086
Schistosoma mansoni	coup transcription factor	0.0029	0.0389	0.086
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0647	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0171	0.4514	0.4514
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0029	0.0389	0.0388
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0389	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0069	0.1557	0.3449
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Echinococcus granulosus	aminopeptidase N	0.0361	1	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0646	0.0673
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0029	0.0389	0.086
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0029	0.0389	0.086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0029	0.0389	0.0405
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0647	0.1444
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0029	0.0389	0.0388
Onchocerca volvulus		0.0106	0.2637	0.246
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0058	0.1229	0.2723
Echinococcus multilocularis	aminopeptidase N	0.0361	1	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0106	0.2637	0.5787
Brugia malayi	photoreceptor-specific nuclear receptor	0.0029	0.0389	0.0389
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0049	0.0985	0.0985
Brugia malayi	hypothetical protein	0.0044	0.0837	0.0837
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0157	0.4087	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0106	0.2637	0.5787
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0066	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0255	0.6929	0.7224
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0171	0.4514	0.4382
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0069	0.1557	0.2649
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0157	0.4087	0.9054
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0389	0.0388
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0533	0.0774
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0058	0.1229	0.2581
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0029	0.0389	0.0388
Onchocerca volvulus	Bile acid receptor homolog	0.0347	0.9591	0.9581
Onchocerca volvulus	Peroxidase homolog	0.0162	0.4241	0.4102
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0106	0.2637	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0029	0.0389	0.0389
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0029	0.0389	0.0405
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0066	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0029	0.0389	0.0389
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0037	0.0646	0.0645
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0235	0.0421
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0029	0.0389	0.0389
Brugia malayi	Inositol-1	0.0037	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Trypanosoma cruzi	aminopeptidase, putative	0.0106	0.2637	0.5787
Brugia malayi	steroid hormone receptor	0.0029	0.0389	0.0389
Brugia malayi	Peptidase family M1 containing protein	0.0037	0.0646	0.0646
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0647	0.1432
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0157	0.4087	1
Brugia malayi	prolyl oligopeptidase family protein	0.0058	0.1229	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1557	0.1624
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0647	0.0006
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0049	0.0985	0.0985
Onchocerca volvulus		0.0029	0.0389	0.0157
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0059	0.126	0.126
Brugia malayi	Animal haem peroxidase family protein	0.0162	0.4241	0.4241
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Echinococcus multilocularis	thymidylate synthase	0.0157	0.4087	0.4087
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0029	0.0389	0.0388
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0029	0.0389	0.0405
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0235	0.0421
Brugia malayi	Steroid receptor seven-up type 2	0.0029	0.0389	0.0389
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0171	0.4514	0.4514
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0235	0.0421
Onchocerca volvulus		0.0162	0.4241	0.4102
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Trypanosoma brucei	Aminopeptidase M1, putative	0.0106	0.2637	0.5787
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0533	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0324	0.892	0.93
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0106	0.2637	0.5787
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Loa Loa (eye worm)	animal heme peroxidase	0.0162	0.4241	0.4422
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0072	0.1652	0.1651
Brugia malayi	thymidylate synthase	0.0157	0.4087	0.4087
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0235	0.0235
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0037	0.0646	0.1429
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0235	0.0245
Schistosoma mansoni	retinoic acid receptor RXR	0.0029	0.0389	0.086
Loa Loa (eye worm)	hypothetical protein	0.0347	0.9591	1
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0037	0.0646	0.1429
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0235	0.0421
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0066	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0235	0.0235
Brugia malayi	Animal haem peroxidase family protein	0.0162	0.4241	0.4241
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0037	0.0646	0.1441
Mycobacterium ulcerans	aminopeptidase N PepN	0.0106	0.2637	0.6394
Echinococcus multilocularis	FTZ F1 alpha	0.0029	0.0389	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0058	0.1229	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0066	0.0069
Loa Loa (eye worm)	thymidylate synthase	0.0157	0.4087	0.4261
Onchocerca volvulus		0.0037	0.0646	0.042
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0106	0.2637	1
Schistosoma mansoni	peroxidasin	0.0162	0.4241	0.9395
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Brugia malayi	hypothetical protein	0.0037	0.0646	0.0646
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0389	0.086
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0157	0.4087	1
Brugia malayi	hypothetical protein	0.0074	0.1717	0.1717
Brugia malayi	nuclear receptor NHR-88	0.0029	0.0389	0.0389
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0029	0.0389	0.0389
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0066	0.0068
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0074	0.1717	0.3112
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.0389	0.086
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0647	0.1068
Onchocerca volvulus	Dual oxidase homolog	0.0162	0.4241	0.4102
Loa Loa (eye worm)	glutamate receptor	0.0059	0.126	0.1314
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0066	0.0069
Brugia malayi	prolyl oligopeptidase family protein	0.0171	0.4514	0.4514
Brugia malayi	TATA binding protein associated factor	0.0037	0.0646	0.0646
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0292	0.8008	0.835
Echinococcus granulosus	FTZ F1 alpha	0.0029	0.0389	0.0388
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0106	0.2637	0.6236
Brugia malayi	Animal haem peroxidase family protein	0.0162	0.4241	0.4241
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0029	0.0389	0.0388
Loa Loa (eye worm)	animal heme peroxidase	0.0162	0.4241	0.4422
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0389	0.0388
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Schistosoma mansoni	RAR-like nuclear receptor	0.0029	0.0389	0.086
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0157	0.4087	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0646	0.0673
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.1717	0.5378
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0389	0.086
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0029	0.0389	0.086
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0647	0.0006
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0157	0.4087	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Brugia malayi	nuclear hormone receptor	0.0029	0.0389	0.0389
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0647	0.5
Echinococcus granulosus	peroxidasin	0.0162	0.4241	0.4241
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1557	0.1624
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0389	0.0389
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0647	0.0004
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0106	0.2637	0.5787
Echinococcus granulosus	ecdysone induced protein 78C	0.0029	0.0389	0.0388
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0157	0.4087	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0235	0.0486
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0029	0.0389	0.0388
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0029	0.0389	0.0405
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0647	0.0646
Brugia malayi	Animal haem peroxidase family protein	0.0162	0.4241	0.4241
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0072	0.1652	0.1651
Onchocerca volvulus		0.0361	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0389	0.0405
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0058	0.1229	0.1697
Brugia malayi	hypothetical protein	0.0162	0.4241	0.4241
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0389	0.086
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0647	0.0004
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0029	0.0389	0.086
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0029	0.0389	0.0388
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0647	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Brugia malayi	Blistered cuticle protein 3	0.0162	0.4241	0.4241
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0837	0.0873
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0029	0.0389	0.0389
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0235	0.0486
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0647	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0235	0.0245
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0029	0.0389	0.0389
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0029	0.0389	0.086
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0058	0.1229	0.1229
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0058	0.1229	0.1697
Loa Loa (eye worm)	steroid hormone receptor	0.0029	0.0389	0.0405
Onchocerca volvulus	Peroxidasin homolog	0.0162	0.4241	0.4102
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0171	0.4514	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0037	0.0646	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0646	0.0673
Onchocerca volvulus		0.0157	0.4087	0.3945
Schistosoma mansoni	peroxidasin	0.0162	0.4241	0.9395
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0029	0.0389	0.0405
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0389	0.0389
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0029	0.0389	0.0388
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0037	0.0646	0.1441
Echinococcus multilocularis	ecdysone induced protein 78C	0.0029	0.0389	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0106	0.2637	0.5841
Entamoeba histolytica	aminopeptidase, putative	0.0106	0.2637	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0106	0.2637	0.2637
Onchocerca volvulus	Peroxidase homolog	0.0162	0.4241	0.4102
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0157	0.4087	1
Echinococcus granulosus	thymidylate synthase	0.0157	0.4087	0.4087
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0106	0.2637	0.2637
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4241	0.4422
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0235	0.0421

Activities

Activity type	Activity value	Assay description	Source	Reference
Response (functional)	0 %	Percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 1 microM; An increase of cAmp content of cells	ChEMBL.	10987425
Response (functional)	0 %	Percentage of response to 10 uM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 10 microM; An increase of cAmp content of cells	ChEMBL.	10987425
Response (functional)	= 10 %	Percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 0.1 microM concentration	ChEMBL.	10987425
Response (functional)	= 10 %	Percentage of response to 10 microM of PD81723 on CHO cells expressing the cloned human A1-adenosine receptor at 0.1 microM concentration	ChEMBL.	10987425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL58123
PubChem: 15434450

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 89186