Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3285 | 0.3273 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0164 | 0.0499 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Schistosoma mansoni | ras GTP exchange factor | 0.0008 | 0.0018 | 0.0054 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0164 | 0.0146 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0164 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0164 | 0.0146 | |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0008 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0164 | 0.0499 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0.0018 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.