Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | nuclear hormone receptor | 0.0075 | 0.3899 | 0.3899 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | nuclear receptor NHR-88 | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0131 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0075 | 0.3899 | 0.3899 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.7054 | 0.8023 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | thyroid hormone receptor | 0.0075 | 0.3899 | 0.3899 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0075 | 0.3899 | 0.4435 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0075 | 0.3899 | 0.3899 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0075 | 0.3899 | 0.3899 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0075 | 0.3899 | 0.3899 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.012 | 0.8791 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0075 | 0.3899 | 0.4435 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0075 | 0.3899 | 0.3899 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0075 | 0.3899 | 0.3899 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.012 | 0.8791 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0075 | 0.3899 | 0.3899 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0075 | 0.3899 | 0.3899 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0075 | 0.3899 | 0.4435 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0075 | 0.3899 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.3899 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.012 | 0.8791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | steroid hormone receptor | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0075 | 0.3899 | 0.4435 |
Echinococcus granulosus | FTZ F1 alpha | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | coup transcription factor | 0.0075 | 0.3899 | 0.3899 |
Brugia malayi | ecdysteroid receptor | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0075 | 0.3899 | 0.4435 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0075 | 0.3899 | 0.4435 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0075 | 0.3899 | 0.4435 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0075 | 0.3899 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0075 | 0.3899 | 0.3899 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0112 | 0.7926 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0075 | 0.3899 | 0.4435 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0075 | 0.3899 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | nuclear hormone receptor | 0.0075 | 0.3899 | 0.4435 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0112 | 0.7926 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0075 | 0.3899 | 0.4435 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0075 | 0.3899 | 0.3899 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.3899 | 0.4435 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.012 | 0.8791 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0075 | 0.3899 | 0.4435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.