Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0096 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0174 | 0.908 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0096 | 0 | 0.5 |
Mycobacterium ulcerans | signal peptidase I LepB | 0.0182 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0096 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0174 | 0.908 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0174 | 0.908 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0174 | 0.908 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0174 | 0.908 | 0.5 |
Mycobacterium tuberculosis | Probable signal peptidase I LepB (SPASE I) (leader peptidase I). | 0.0182 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0174 | 0.908 | 0.5 |
Treponema pallidum | signal peptidase I (sip) | 0.0131 | 0.4056 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0096 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0096 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0096 | 0 | 0.5 |
Treponema pallidum | signal peptidase I | 0.0131 | 0.4056 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0174 | 0.908 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Signal peptidase I | 0.0182 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.