Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0679 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0342 | 0.4402 | 0.4402 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0679 | 1 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.026 | 0.3033 | 0.3033 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0679 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.026 | 0.3033 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.026 | 0.3033 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.026 | 0.3033 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0679 | 1 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0077 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0337 | 0.4316 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0679 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0679 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0337 | 0.4316 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0679 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0602 | 0.8717 | 0.8159 |
Giardia lamblia | Hypothetical protein | 0.0602 | 0.8717 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0679 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0679 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0337 | 0.4316 | 0.4316 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0679 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0679 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0419 | 0.5684 | 0.5684 |
Leishmania major | hypothetical protein, conserved | 0.026 | 0.3033 | 0.3033 |
Echinococcus granulosus | methionine synthase reductase | 0.0419 | 0.5684 | 0.5684 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.026 | 0.3033 | 0.3033 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.026 | 0.3033 | 0.3033 |
Echinococcus multilocularis | methionine synthase reductase | 0.0419 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.026 | 0.3033 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0679 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.026 | 0.3033 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.026 | 0.3033 | 0.3033 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0679 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0419 | 0.5684 | 0.5684 |
Chlamydia trachomatis | sulfite reductase | 0.0419 | 0.5684 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0679 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0679 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0679 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0543 | 0.7739 | 0.7739 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.026 | 0.3033 | 0.3033 |
Leishmania major | cytochrome P450 reductase, putative | 0.0602 | 0.8717 | 0.8717 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0679 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0602 | 0.8717 | 0.8717 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0602 | 0.8717 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.026 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0077 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.026 | 0.3033 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0679 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0679 | 1 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.026 | 0.3033 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0679 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.026 | 0.3033 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0419 | 0.5684 | 0.5684 |
Plasmodium vivax | hypothetical protein, conserved | 0.026 | 0.3033 | 0.3033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0679 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0679 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.