Detailed information for compound 892421

Basic information

Technical information
  • TDR Targets ID: 892421
  • Name: ethyl 6-(4-bromophenyl)-4-furan-2-yl-2-oxocyc lohex-3-ene-1-carboxylate
  • MW: 389.24 | Formula: C19H17BrO4
  • H donors: 0 H acceptors: 2 LogP: 3.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1C(=O)C=C(CC1c1ccc(cc1)Br)c1ccco1
  • InChi: 1S/C19H17BrO4/c1-2-23-19(22)18-15(12-5-7-14(20)8-6-12)10-13(11-16(18)21)17-4-3-9-24-17/h3-9,11,15,18H,2,10H2,1H3
  • InChiKey: SERARALDUWHHHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-(4-bromophenyl)-4-(2-furyl)-2-oxo-cyclohex-3-ene-1-carboxylate
  • 6-(4-bromophenyl)-4-(2-furyl)-2-oxo-1-cyclohex-3-enecarboxylic acid ethyl ester
  • 6-(4-bromophenyl)-4-(2-furyl)-2-keto-cyclohex-3-ene-1-carboxylic acid ethyl ester
  • ethyl 6-(4-bromophenyl)-4-furan-2-yl-2-oxo-cyclohex-3-ene-1-carboxylate
  • EU-0053379
  • A2858/0120486

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.1096 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3033 0.3414
Schistosoma mansoni nAChR subunit 0.0037 0.1206 0.1636
Echinococcus multilocularis glycine receptor subunit beta 0.0079 0.3033 0.4116
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.3033 0.4116
Loa Loa (eye worm) ACC-1 protein 0.0079 0.3033 0.341
Brugia malayi Carboxylesterase family protein 0.0024 0.0667 0.0686
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.3033 0.4116
Loa Loa (eye worm) LGC-31 protein 0.0079 0.3033 0.341
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Onchocerca volvulus 0.0029 0.0894 0.0243
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Brugia malayi hypothetical protein 0.0024 0.0667 0.0686
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.2569 0.3486
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.2569 0.3486
Echinococcus multilocularis transient receptor potential ion channel A 0.01 0.392 0.532
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.1254 0.1702
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.1254 0.1363
Echinococcus granulosus neuroligin 0.0024 0.0667 0.0905
Brugia malayi Transient-receptor-potential like protein 0.0038 0.1287 0.1402
Onchocerca volvulus 0.0079 0.3033 0.2535
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.2569 0.3486
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.1254 1
Brugia malayi Pre-SET motif family protein 0.0213 0.8746 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.1254 0.1702
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.1287 0.1747
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.1096 1
Brugia malayi Carboxylesterase family protein 0.0142 0.5713 0.6503
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.1287 0.1747
Echinococcus granulosus acetylcholinesterase 0.0142 0.5713 0.7753
Schistosoma mansoni transient receptor potential channel 0.0103 0.4067 0.552
Echinococcus multilocularis nAChR subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) hypothetical protein 0.0038 0.1254 0.1358
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0076 0.0104
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Echinococcus multilocularis acetylcholinesterase 0.0142 0.5713 0.7753
Brugia malayi hypothetical protein 0.0037 0.1206 0.1307
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0079 0.3033 0.4116
Schistosoma mansoni neurotransmitter gated ion channel 0.0043 0.1468 0.1992
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0037 0.1206 0.1302
Schistosoma mansoni hypothetical protein 0.018 0.7369 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.114 0.1226
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0079 0.3033 0.4116
Onchocerca volvulus 0.0079 0.3033 0.2535
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3033 0.3414
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.3033 0.3414
Loa Loa (eye worm) hypothetical protein 0.0024 0.0656 0.0668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.097 0.1317
Echinococcus multilocularis nAChR subunit 0.0043 0.1468 0.1992
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.1254 1
Schistosoma mansoni transient receptor potential channel 0.0068 0.2569 0.3486
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3033 0.3414
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0142 0.5713 0.6501
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0037 0.1206 0.1307
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0667 0.0905
Loa Loa (eye worm) acetylcholine receptor protein 0.0037 0.1206 0.1302
Echinococcus granulosus pyruvate kinase 0.0034 0.1096 0.1487
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Loa Loa (eye worm) hypothetical protein 0.0065 0.2421 0.2705
Loa Loa (eye worm) carboxylesterase 0.0024 0.0667 0.0681
Onchocerca volvulus 0.0037 0.1206 0.0577
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0081 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.3033 0.3414
Echinococcus granulosus pyruvate kinase 0.0034 0.1096 0.1487
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0667 0.0905
Echinococcus granulosus nAChR subunit 0.0043 0.1468 0.1992
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0037 0.1206 0.1636
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.097 0.348
Trichomonas vaginalis set domain proteins, putative 0.0242 1 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0079 0.3033 0.3414
Schistosoma mansoni pyruvate kinase 0.0034 0.1096 0.1487
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.1096 0.423
Brugia malayi Carboxylesterase family protein 0.0142 0.5713 0.6503
Onchocerca volvulus 0.0031 0.097 0.0325
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Schistosoma mansoni pyruvate kinase 0.0017 0.0388 0.0526
Echinococcus granulosus cpg binding protein 0.0031 0.0965 0.131
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0037 0.1206 0.1307
Echinococcus granulosus transient receptor potential gamma protein 0.0103 0.4067 0.552
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.1254 0.1702
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3033 0.3414
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.1254 0.7362
Echinococcus multilocularis glycine receptor subunit beta 0.0079 0.3033 0.4116
Schistosoma mansoni cpg binding protein 0.0031 0.0965 0.131
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0079 0.3033 0.3414
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.1254 0.1702
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.2062 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0079 0.3033 0.341
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0667 0.0905
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.1254 0.0629
Schistosoma mansoni transient receptor potential channel 4 0.0103 0.4067 0.552
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0667 0.0905
Echinococcus granulosus nAChR subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Brugia malayi hypothetical protein 0.0037 0.1206 0.1307
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0079 0.3033 0.4116
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0079 0.3033 0.4116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.097 0.1317
Loa Loa (eye worm) hypothetical protein 0.0034 0.1096 0.1176
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.1468 0.161
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.1206 0.1636
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Loa Loa (eye worm) hypothetical protein 0.0154 0.6232 0.71
Echinococcus granulosus glycine receptor subunit beta 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Brugia malayi CXXC zinc finger family protein 0.0029 0.0894 0.0948
Schistosoma mansoni hypothetical protein 0.018 0.7369 1
Echinococcus granulosus acetylcholinesterase 0.0142 0.5713 0.7753
Onchocerca volvulus 0.0037 0.1206 0.0577
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0667 0.0905
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.1254 0.1702
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0079 0.3033 0.341
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.1096 0.1181
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Entamoeba histolytica hypothetical protein 0.0043 0.1468 1
Onchocerca volvulus Putative nachr subunit 0.0079 0.3033 0.2535
Schistosoma mansoni nAChR subunit 0.0037 0.1206 0.1636
Echinococcus multilocularis acetylcholinesterase 0.0142 0.5713 0.7753
Onchocerca volvulus 0.0037 0.1206 0.0577
Loa Loa (eye worm) hypothetical protein 0.0038 0.1287 0.1397
Brugia malayi Carboxylesterase family protein 0.0024 0.0667 0.0686
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0079 0.3033 0.3414
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.1254 0.0629
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0079 0.3033 0.4116
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0043 0.1468 0.1992
Brugia malayi Pre-SET motif family protein 0.0031 0.097 0.1036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.1254 0.1702
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.1254 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Chlamydia trachomatis pyruvate kinase 0.0034 0.1096 0.5
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0079 0.3033 0.4116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.1468 0.1992
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.1206 0.1636
Echinococcus granulosus glycine receptor subunit beta 0.0079 0.3033 0.4116
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0667 0.0905
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0079 0.3033 0.3414
Brugia malayi Cation transporter family protein 0.0079 0.3033 0.3414
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.1468 0.161
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.097 0.1317
Brugia malayi hypothetical protein 0.0037 0.1206 0.1307
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0079 0.3033 0.341
Echinococcus multilocularis cpg binding protein 0.0031 0.0965 0.131
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0031 0.097 0.1031
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0079 0.3033 0.3414
Brugia malayi excitatory GABA receptor EXP-1A 0.0079 0.3033 0.3414
Echinococcus multilocularis pyruvate kinase 0.0017 0.0388 0.0526
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.1096 0.1181
Echinococcus granulosus geminin 0.018 0.7369 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1206 0.1307
Echinococcus granulosus transient receptor potential ion channel A 0.01 0.392 0.532
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0079 0.3033 0.4116
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0079 0.3033 0.4116
Brugia malayi Carboxylesterase family protein 0.0024 0.0667 0.0686
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.097 0.1317
Brugia malayi hypothetical protein 0.0037 0.1206 0.1307
Echinococcus multilocularis carboxylesterase 5A 0.0142 0.5713 0.7753
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0037 0.1206 0.1636
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.1254 0.1702
Echinococcus multilocularis geminin 0.018 0.7369 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0142 0.5713 0.6501
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0656 0.0668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.097 0.1317
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.2569 0.3486
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.3033 0.4116
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.1254 0.1702
Schistosoma mansoni gliotactin 0.0024 0.0667 0.0905
Loa Loa (eye worm) hypothetical protein 0.0142 0.5713 0.6501
Brugia malayi Carboxylesterase family protein 0.0024 0.0667 0.0686
Loa Loa (eye worm) ACC-1 protein 0.0079 0.3033 0.341
Onchocerca volvulus 0.0079 0.3033 0.2535
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Schistosoma mansoni acetylcholinesterase 0.0024 0.0667 0.0905
Plasmodium vivax pyruvate kinase, putative 0.0034 0.1096 1
Onchocerca volvulus 0.0043 0.1468 0.0859
Echinococcus multilocularis transient receptor potential gamma protein 0.0103 0.4067 0.552
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.1206 0.1302
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.1096 0.046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3033 0.3414
Echinococcus granulosus pyruvate kinase 0.0017 0.0388 0.0526
Onchocerca volvulus 0.0043 0.1468 0.0859
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1096 0.1176
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.097 0.1317
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.097 0.1317
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0895 0.1215
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.1254 0.0629
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0079 0.3033 0.4116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.1254 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1096 0.046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0894 0.0943
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Mycobacterium ulcerans pyruvate kinase 0.0034 0.1096 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0079 0.3033 0.4116
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0079 0.3033 0.3414
Echinococcus granulosus pyruvate kinase 0.0017 0.0388 0.0526
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1096 0.1176
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0076 0.0104
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0667 0.0905
Echinococcus multilocularis pyruvate kinase 0.0034 0.1096 0.1487
Onchocerca volvulus 0.0079 0.3033 0.2535
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0667 0.0905
Plasmodium falciparum pyruvate kinase 0.0034 0.1096 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Brugia malayi Cation transporter family protein 0.0079 0.3033 0.3414
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Schistosoma mansoni pyruvate kinase 0.0034 0.1096 0.1487
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.2346 0.3183
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1206 0.1307
Loa Loa (eye worm) hypothetical protein 0.0103 0.4067 0.4603
Echinococcus multilocularis pyruvate kinase 0.0034 0.1096 0.1487
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1096 0.046
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Echinococcus multilocularis pyruvate kinase 0.0027 0.0789 0.1071
Schistosoma mansoni cpg binding protein 0.0031 0.0965 0.131
Echinococcus granulosus pyruvate kinase 0.0017 0.0388 0.0526
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0037 0.1206 0.1636
Brugia malayi Cation transporter family protein 0.0079 0.3033 0.3414
Schistosoma mansoni nAChR subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Echinococcus granulosus carboxylesterase 5A 0.0142 0.5713 0.7753
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) carboxylesterase 0.0142 0.5713 0.6501
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0079 0.3033 0.341
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0079 0.3033 0.4116
Echinococcus multilocularis neuroligin 0.0024 0.0667 0.0905
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0667 0.0905
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.8746 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.1206 0.1636
Onchocerca volvulus 0.0079 0.3033 0.2535
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1206 0.1307
Loa Loa (eye worm) GABA receptor subunit 0.0043 0.1468 0.1605
Schistosoma mansoni acetylcholine receptor subunit beta 0.0037 0.1206 0.1636
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0079 0.3033 0.4116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.5713 0.7753
Giardia lamblia Pyruvate kinase 0.0034 0.1096 0.8176
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0079 0.3033 0.4116
Echinococcus multilocularis pyruvate kinase 0.0017 0.0388 0.0526
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.3033 0.3414
Schistosoma mansoni neurotransmitter gated ion channel 0.0037 0.1206 0.1636
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0037 0.1206 0.1302
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605
Plasmodium vivax SET domain protein, putative 0.0031 0.097 0.8227
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0079 0.3033 0.3414
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0079 0.3033 0.341
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0667 0.0905
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0079 0.3033 0.4116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Schistosoma mansoni transient receptor potential channel 0.0068 0.2569 0.3486
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.1254 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.3033 0.341
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.3033 0.4116
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0079 0.3033 0.341
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.3033 0.4116
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.1096 0.5
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0079 0.3033 0.4116
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3033 0.3414
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1096 0.046
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1096 0.1176
Loa Loa (eye worm) carboxylesterase 0.0024 0.0667 0.0681
Schistosoma mansoni cpg binding protein 0.0029 0.0894 0.1213
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0079 0.3033 0.4116
Brugia malayi hypothetical protein 0.0154 0.6232 0.7102
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0043 0.1468 0.161
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0043 0.1468 0.161
Onchocerca volvulus 0.0154 0.6232 0.5962
Onchocerca volvulus 0.0079 0.3033 0.2535
Schistosoma mansoni acetylcholine receptor-related 0.0037 0.1206 0.1636
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0667 0.0905
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0037 0.1206 0.1307
Echinococcus multilocularis pyruvate kinase 0.0017 0.0388 0.0526
Brugia malayi hypothetical protein 0.0037 0.1206 0.1307
Loa Loa (eye worm) hypothetical protein 0.0024 0.0667 0.0681
Loa Loa (eye worm) hypothetical protein 0.0043 0.1468 0.1605

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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