Detailed information for compound 892444

Basic information

Technical information
  • TDR Targets ID: 892444
  • Name: 6-[(E)-2-(4-methoxyphenyl)ethenyl]-1,3-dimeth yl-5-nitropyrimidine-2,4-dione
  • MW: 317.297 | Formula: C15H15N3O5
  • H donors: 0 H acceptors: 4 LogP: 1.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/c1n(C)c(=O)n(c(=O)c1[N+](=O)[O-])C
  • InChi: 1S/C15H15N3O5/c1-16-12(9-6-10-4-7-11(23-3)8-5-10)13(18(21)22)14(19)17(2)15(16)20/h4-9H,1-3H3/b9-6+
  • InChiKey: DORJPRXOQFWKQJ-RMKNXTFCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[2-(4-methoxyphenyl)ethenyl]-1,3-dimethyl-5-nitropyrimidine-2,4-dione
  • 6-[(E)-2-(4-methoxyphenyl)vinyl]-1,3-dimethyl-5-nitro-pyrimidine-2,4-dione
  • 6-[2-(4-methoxyphenyl)vinyl]-1,3-dimethyl-5-nitro-pyrimidine-2,4-dione
  • 6-[(E)-2-(4-methoxyphenyl)vinyl]-1,3-dimethyl-5-nitropyrimidine-2,4-dione
  • 6-[2-(4-methoxyphenyl)vinyl]-1,3-dimethyl-5-nitropyrimidine-2,4-dione
  • 6-[2-(4-methoxyphenyl)vinyl]-1,3-dimethyl-5-nitro-pyrimidine-2,4-quinone
  • 6-[(E)-2-(4-methoxyphenyl)vinyl]-1,3-dimethyl-5-nitro-pyrimidine-2,4-quinone
  • 6-[(E)-2-(4-methoxyphenyl)ethenyl]-1,3-dimethyl-5-nitro-pyrimidine-2,4-dione
  • 6-[2-(4-methoxyphenyl)ethenyl]-1,3-dimethyl-5-nitro-pyrimidine-2,4-dione
  • 741-86-6
  • NSC86919
  • BAS 03160865
  • MLS000718977
  • SMR000291245
  • 6-[2-(4-Methoxy-phenyl)-vinyl]-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione
  • A2836/0119746
  • ZINC04580244

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0354 0.0373
Brugia malayi Dihydrofolate reductase 0.0971 0.992 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.2552
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0056 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0354 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.032 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.032 0.0302
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0354 0.0876
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0371 0.3767 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Trichomonas vaginalis hypothetical protein 0.0007 0.0026 0.0094
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0397 0.1431
Entamoeba histolytica Ran family GTPase 0.0026 0.0221 0.5271
Echinococcus multilocularis pyruvate kinase 0.002 0.0161 0.0136
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0234 0.021
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.0197
Brugia malayi Muscleblind-like protein 0.018 0.1808 0.1801
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0354 0.0876
Leishmania major pyruvate kinase 0.0039 0.0354 0.0876
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0354 0.0876
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.0197
Echinococcus granulosus pyruvate kinase 0.0039 0.0354 0.0331
Echinococcus multilocularis pyruvate kinase 0.0039 0.0354 0.0328
Schistosoma mansoni cpg binding protein 0.0033 0.0299 0.0281
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0371 0.3767 1
Schistosoma mansoni dihydrofolate reductase 0.0971 0.992 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0616 0.1577
Echinococcus granulosus snurportin 1 0.0372 0.377 0.3785
Schistosoma mansoni ran 0.0026 0.0221 0.0203
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0397 0.038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0129
Brugia malayi hypothetical protein 0.0175 0.1748 0.1741
Loa Loa (eye worm) hypothetical protein 0.0175 0.1748 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0077 0.0051
Brugia malayi pyruvate kinase 0.0008 0.0042 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.032 0.0784
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0299 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.032 0.0302
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0397 0.0371
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0397 0.0371
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0316 0.029
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0354 0.0331
Chlamydia trachomatis dihydrofolate reductase 0.0971 0.992 1
Echinococcus granulosus pyruvate kinase 0.002 0.0161 0.0137
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.377 0.3785
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0077 0.0051
Loa Loa (eye worm) hypothetical protein 0.018 0.1808 0.1801
Echinococcus multilocularis snurportin 1 0.0372 0.377 0.3754
Schistosoma mansoni cpg binding protein 0.0035 0.0318 0.0301
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0129
Loa Loa (eye worm) hypothetical protein 0.0039 0.0354 0.0331
Echinococcus multilocularis muscleblind protein 1 0.018 0.1808 0.1787
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0036 0.0129
Brugia malayi Pre-SET motif family protein 0.0241 0.2431 0.2431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0397 0.0374
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0371 0.3767 1
Trichomonas vaginalis ran, putative 0.0026 0.0221 0.0799
Leishmania major importin beta-1 subunit, putative 0.0028 0.0248 0.0593
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0971 0.992 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0299 0.0276
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0161 0.0362
Entamoeba histolytica hypothetical protein 0.0028 0.0248 0.5993
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0221 0.0522
Echinococcus granulosus cpg binding protein 0.0035 0.0318 0.0295
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0397 0.0371
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0371 0.3767 1
Onchocerca volvulus 0.0175 0.1748 0.5862
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0221 0.0522
Trichomonas vaginalis helicase, putative 0.0008 0.0036 0.0129
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0397 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0248 0.0895
Schistosoma mansoni cpg binding protein 0.0035 0.0318 0.0301
Echinococcus granulosus pyruvate kinase 0.0039 0.0354 0.0331
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0354 0.0331
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0354 0.0222
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0221 0.0522
Leishmania major GTP-binding protein, putative 0.0026 0.0221 0.0522
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0221 0.0197
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0248 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0078 0.0053
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0299 0.0276
Brugia malayi RNA, U transporter 1 0.0099 0.0974 0.0958
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0042 0.0016
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0248 0.0895
Echinococcus multilocularis muscleblind protein 0.018 0.1808 0.1787
Brugia malayi Pre-SET motif family protein 0.0035 0.032 0.0297
Schistosoma mansoni importin-beta 2 0.0007 0.0026 0.0006
Schistosoma mansoni pyruvate kinase 0.0039 0.0354 0.0337
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0316 0.0774
Giardia lamblia Pyruvate kinase 0.0039 0.0354 0.8176
Echinococcus multilocularis dihydrofolate reductase 0.0971 0.992 0.992
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0354 0.0331
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0397 1
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0354 0.0222
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0056 0.003
Schistosoma mansoni hypothetical protein 0.0372 0.377 0.3788
Schistosoma mansoni ran 0.0026 0.0221 0.0203
Brugia malayi Importin beta-1 subunit 0.0035 0.0316 0.0293
Onchocerca volvulus 0.0274 0.2771 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.032 0.0294
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0234 0.5615
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0397 0.038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0248 0.0895
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0056 0.003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0397 0.099
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.2431 0.2431
Loa Loa (eye worm) hypothetical protein 0.018 0.1808 0.1801
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0129
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0354 0.0331
Plasmodium falciparum importin beta, putative 0.0035 0.0316 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0371 0.3767 1
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0161 0.0362
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0371 0.3767 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0316 0.0774
Echinococcus multilocularis pyruvate kinase 0.002 0.0161 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0397 0.1431
Echinococcus granulosus pyruvate kinase 0.002 0.0161 0.0137
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0354 0.0222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0129
Echinococcus multilocularis cpg binding protein 0.0035 0.0318 0.0293
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0397 0.0494
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0077 0.0051
Loa Loa (eye worm) dihydrofolate reductase 0.0971 0.992 1
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0354 0.1276
Trichomonas vaginalis set domain proteins, putative 0.0274 0.2771 1
Echinococcus granulosus dihydrofolate reductase 0.0971 0.992 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0397 0.0494
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0354 0.0373
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0042 0.0016
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0397 0.0374
Onchocerca volvulus 0.0035 0.032 0.0084
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0316 0.0774
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0076 0.005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0693 0.068
Plasmodium vivax SET domain protein, putative 0.0035 0.032 0.0784
Schistosoma mansoni pyruvate kinase 0.0039 0.0354 0.0337
Plasmodium falciparum pyruvate kinase 2 0.002 0.0161 0.0362
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0221 0.0196
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0397 0.0374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0316 0.0293
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0129
Leishmania major pyruvate kinase 0.0039 0.0354 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0036 0.0129
Echinococcus multilocularis pyruvate kinase 0.003 0.027 0.0245
Echinococcus multilocularis pyruvate kinase 0.0039 0.0354 0.0328
Echinococcus granulosus importin subunit beta 1 0.0035 0.0316 0.0293
Schistosoma mansoni pyruvate kinase 0.002 0.0161 0.0142
Echinococcus multilocularis pyruvate kinase 0.002 0.0161 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.032 0.0297
Loa Loa (eye worm) hypothetical protein 0.0027 0.0234 0.021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0036 0.0129
Echinococcus granulosus pyruvate kinase 0.002 0.0161 0.0137
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0397 0.099
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0056 0.003
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0221 0.0522
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0056 0.003
Echinococcus granulosus muscleblind protein 0.018 0.1808 0.1801
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.032 0.0302
Brugia malayi dihydrofolate reductase family protein 0.0971 0.992 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.032 0.0294
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0971 0.992 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0971 0.992 1
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0397 0.0374
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0397 0.1431
Plasmodium falciparum pyruvate kinase 0.0039 0.0354 0.0876
Plasmodium vivax importin-beta 2, putative 0.0035 0.0316 0.0774
Loa Loa (eye worm) hypothetical protein 0.0043 0.0397 0.0374
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0354 0.1276
Schistosoma mansoni importin beta-1 0.0035 0.0316 0.0298
Loa Loa (eye worm) hypothetical protein 0.0035 0.032 0.0297
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0354 0.0331

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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