Detailed information for compound 892534

Basic information

Technical information
  • TDR Targets ID: 892534
  • Name: propyl 4-(2-chloro-6-fluorophenyl)-1,6-dimeth yl-2-oxo-3,4-dihydropyrimidine-5-carboxylate
  • MW: 340.777 | Formula: C16H18ClFN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOC(=O)C1=C(C)N(C)C(=O)NC1c1c(F)cccc1Cl
  • InChi: 1S/C16H18ClFN2O3/c1-4-8-23-15(21)12-9(2)20(3)16(22)19-14(12)13-10(17)6-5-7-11(13)18/h5-7,14H,4,8H2,1-3H3,(H,19,22)
  • InChiKey: WGIVDIUEFDXMPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • propyl 4-(2-chloro-6-fluoro-phenyl)-1,6-dimethyl-2-oxo-3,4-dihydropyrimidine-5-carboxylate
  • 4-(2-chloro-6-fluorophenyl)-1,6-dimethyl-2-oxo-3,4-dihydropyrimidine-5-carboxylic acid propyl ester
  • 4-(2-chloro-6-fluoro-phenyl)-2-keto-1,6-dimethyl-3,4-dihydropyrimidine-5-carboxylic acid propyl ester
  • A2849/0120265

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.3397 0.3397
Loa Loa (eye worm) TK/ROR protein kinase 0.0028 0.4162 0.4162
Loa Loa (eye worm) hypothetical protein 0.0028 0.4162 0.4162
Schistosoma mansoni intermediate filament proteins 0.0026 0.3537 0.6116
Echinococcus granulosus lamin dm0 0.0026 0.3537 0.8349
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0375 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0375 0.0375
Echinococcus granulosus lamin 0.0026 0.3537 0.8349
Loa Loa (eye worm) hypothetical protein 0.0026 0.3537 0.3537
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.5545 0.5545
Echinococcus granulosus intermediate filament protein 0.0026 0.3537 0.8349
Onchocerca volvulus 0.0028 0.4162 1
Brugia malayi Protein kinase domain containing protein 0.0028 0.4162 0.4162
Leishmania major hypothetical protein, conserved 0.0028 0.4162 0.5
Loa Loa (eye worm) intermediate filament protein 0.0026 0.3537 0.3537
Brugia malayi intermediate filament protein 0.0026 0.3537 0.3537
Echinococcus multilocularis lamin 0.0026 0.3537 0.8349
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0028 0.4162 0.5
Schistosoma mansoni lamin 0.0026 0.3537 0.6116
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0375 0.0375
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.4162 0.5
Schistosoma mansoni hypothetical protein 0.0033 0.5545 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.3537 0.3537
Schistosoma mansoni hypothetical protein 0.0028 0.4162 0.7325
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.5545 0.5545
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.3537 0.3537
Schistosoma mansoni lamin 0.0026 0.3537 0.6116
Echinococcus multilocularis musashi 0.0026 0.3537 0.8349
Echinococcus multilocularis lamin dm0 0.0026 0.3537 0.8349
Loa Loa (eye worm) hypothetical protein 0.0049 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 1 1
Echinococcus multilocularis tissue type plasminogen activator 0.0028 0.4162 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0028 0.4162 0.5
Toxoplasma gondii kringle domain-containing protein 0.0028 0.4162 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.0375 0.0375
Brugia malayi Kringle domain containing protein 0.0028 0.4162 0.4162
Echinococcus granulosus tissue type plasminogen activator 0.0028 0.4162 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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