Detailed information for compound 892783

Basic information

Technical information
  • TDR Targets ID: 892783
  • Name: [2-methoxy-4-[(E)-(4-oxo-3-phenyl-2-sulfanyli dene-1,3-thiazolidin-5-ylidene)methyl]phenyl] 3-methylbenzoate
  • MW: 461.553 | Formula: C25H19NO4S2
  • H donors: 0 H acceptors: 2 LogP: 6.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC(=O)c1cccc(c1)C)/C=C\1/SC(=S)N(C1=O)c1ccccc1
  • InChi: 1S/C25H19NO4S2/c1-16-7-6-8-18(13-16)24(28)30-20-12-11-17(14-21(20)29-2)15-22-23(27)26(25(31)32-22)19-9-4-3-5-10-19/h3-15H,1-2H3/b22-15+
  • InChiKey: VAYWWTCEQJPWNX-PXLXIMEGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-methoxy-4-[(E)-(4-oxo-3-phenyl-2-thioxo-thiazolidin-5-ylidene)methyl]phenyl] 3-methylbenzoate
  • 3-methylbenzoic acid [2-methoxy-4-[(E)-(4-oxo-3-phenyl-2-thioxo-5-thiazolidinylidene)methyl]phenyl] ester
  • 3-methylbenzoic acid [4-[(E)-(4-keto-3-phenyl-2-thioxo-thiazolidin-5-ylidene)methyl]-2-methoxy-phenyl] ester
  • 5666-94-4
  • AH-034/34958030
  • STK069493
  • BIM-0009367.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0026 0.0062
Schistosoma mansoni jumonji domain containing protein 0.0077 0.105 0.1683
Echinococcus granulosus FTZ F1 alpha 0.001 0.0026 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0026 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0806 0.1953
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0167 0.0405
Brugia malayi hypothetical protein 0.0046 0.0582 0.141
Plasmodium vivax JmjC domain containing protein 0.001 0.0015 0.0257
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0167 0.0268
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.134 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.141
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0153 0.0372
Schistosoma mansoni amine oxidase 0.0046 0.0582 0.0932
Echinococcus multilocularis expressed protein 0.0378 0.5683 0.9107
Brugia malayi PXA domain containing protein 0.0019 0.0167 0.0405
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0167 0.0268
Mycobacterium tuberculosis Possible oxidoreductase 0.0046 0.0582 0.0619
Brugia malayi glutaminase DH11.1 0.0277 0.4127 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0026 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0026 0.0062
Schistosoma mansoni phd/f-box containing protein 0.001 0.0015 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0814 0.0814
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0026 0.0041
Schistosoma mansoni cpg binding protein 0.0031 0.0341 0.0547
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0167 0.0268
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0046 0.0582 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0167 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0597 0.1446
Brugia malayi amine oxidase, flavin-containing family protein 0.0046 0.0582 0.141
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0026 0.0041
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0015 0.0024
Brugia malayi hypothetical protein 0.0019 0.0167 0.0405
Schistosoma mansoni coup transcription factor 0.001 0.0026 0.0041
Echinococcus multilocularis 0.0046 0.0582 0.0932
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0046 0.0582 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0026 0.0062
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0167 0.0268
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0046 0.0582 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0026 0.0062
Brugia malayi CXXC zinc finger family protein 0.0029 0.0316 0.0765
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0015 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0026 0.0062
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.134 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0323 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0172 0.0275
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0046 0.0582 0.0932
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0026 0.0062
Brugia malayi hypothetical protein 0.0089 0.1241 0.3007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0405
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0026 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0026 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0026 0.0062
Schistosoma mansoni jumonji domain containing protein 0.001 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0026 0.0062
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0172 0.0275
Echinococcus granulosus dnaJ subfamily B 0.0414 0.6241 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0444 0.0711
Leishmania major UDP-galactopyranose mutase 0.0046 0.0582 0.4342
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.6241 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0046 0.0582 0.0582
Brugia malayi jmjC domain containing protein 0.001 0.0015 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0026 0.0062
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1728 0.4188
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.134 0.2147
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0167 0.0268
Trypanosoma cruzi UDP-galactopyranose mutase 0.0046 0.0582 0.4342
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0026 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0026 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0026 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0026 0.0041
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0167 0.0268
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0814 0.1305
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0026 0.0192
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0017 0.0206
Echinococcus multilocularis phd:f box containing protein 0.001 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0814 0.1305
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.141
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.134 0.3247
Chlamydia trachomatis protoporphyrinogen oxidase 0.0046 0.0582 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0582 0.0619
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.141
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Toxoplasma gondii histone lysine-specific demethylase 0.0046 0.0582 0.7145
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0015 0.0036
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0167 0.0268
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0167 0.0405
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1728 0.4188
Onchocerca volvulus 0.0046 0.0582 0.4342
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0172 0.0416
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0007 0.0016
Onchocerca volvulus 0.001 0.0026 0.0192
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0015 0.0024
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0167 0.0405
Schistosoma mansoni kinase 0.0049 0.0616 0.0987
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0015 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0405
Schistosoma mansoni amine oxidase 0.0046 0.0582 0.0932
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0172 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0026 0.0062
Echinococcus granulosus peregrin 0.003 0.0323 0.0517
Brugia malayi PHD-finger family protein 0.003 0.0323 0.0781
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0026 0.0062
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0814 0.0866
Loa Loa (eye worm) glutaminase 2 0.0277 0.4127 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.001 0.0015 0.0111
Echinococcus granulosus phd:f box containing protein 0.001 0.0015 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0026 0.0041
Schistosoma mansoni nuclear hormone receptor 0.001 0.0026 0.0041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.1356 0.2173
Brugia malayi nuclear hormone receptor 0.001 0.0026 0.0062
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0167 0.0268
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0015 0.0257
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0044 0.0757
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0167 0.0405
Plasmodium falciparum phd finger protein, putative 0.003 0.0323 0.5543
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0015 0.0183
Brugia malayi SWIRM domain containing protein 0.0046 0.0582 0.141
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0167 0.0405
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0026 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0167 0.0405
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0036
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0026 0.0041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.134 1
Schistosoma mansoni protein phosphatase 2C 0.001 0.0015 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0814 0.1305
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0017 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0172 0.0275
Brugia malayi jmjC domain containing protein 0.001 0.0015 0.0036
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0659 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0026 0.0041
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0017 0.0125
Schistosoma mansoni hypothetical protein 0.003 0.0323 0.0517
Schistosoma mansoni thyroid hormone receptor 0.001 0.0026 0.0041
Schistosoma mansoni thyroid hormone receptor 0.001 0.0026 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0026 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0405
Brugia malayi PXA domain containing protein 0.0019 0.0167 0.0405
Echinococcus granulosus jumonji domain containing protein 0.0041 0.05 0.0802
Treponema pallidum hypothetical protein 0.0009 0 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.1356 0.2173
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0026 0.0041
Entamoeba histolytica hypothetical protein 0.0019 0.0167 0.1246
Mycobacterium ulcerans monoamine oxidase 0.0046 0.0582 0.0582
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0026 0.0041
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0167 0.0268
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0048 0.0609 0.748
Schistosoma mansoni hypothetical protein 0.001 0.0017 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0444 0.0711
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0102
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0167 0.0268
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0167 0.0268
Loa Loa (eye worm) hypothetical protein 0.0089 0.1241 0.3007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0011
Brugia malayi AF-10 protein 0.001 0.0017 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0817 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0167 0.0405
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0026 0.0041
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0046 0.0582 0.0932
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0026 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0167 0.0405
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0167 0.0268
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0814 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0167 0.0268
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0046 0.0582 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0026 0.0062
Onchocerca volvulus 0.0029 0.0316 0.2356
Entamoeba histolytica hypothetical protein 0.0019 0.0167 0.1246
Mycobacterium ulcerans glutaminase 0.0277 0.4127 0.4127
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0167 0.0268
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.134 1
Echinococcus multilocularis peregrin 0.003 0.0323 0.0517
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0015 0.0036
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.134 0.3247
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0026 0.0041
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0167 0.0268
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0015 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0405
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0167 0.0268
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0613 0.9287 0.9874
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0167 0.0405
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0046 0.0582 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0026 0.0062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0026 0.0041
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0017 0.0125
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0026 0.0041
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0167 0.0268
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0172 0.0275
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0814 0.1305
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.134 0.2147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0444 0.0711
Plasmodium vivax hypothetical protein, conserved 0.003 0.0323 0.5543
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0323 0.0517
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1241 0.3007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0814 0.0814
Echinococcus granulosus lysine specific histone demethylase 1A 0.0046 0.0582 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0026 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0026 0.0062
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0167 0.0268
Schistosoma mansoni eyes absent homolog 0.0089 0.1241 0.1989
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0167 0.0405
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0026 0.0062
Schistosoma mansoni cpg binding protein 0.0029 0.0316 0.0506
Echinococcus granulosus cpg binding protein 0.0031 0.0341 0.0547
Echinococcus multilocularis cpg binding protein 0.0031 0.0341 0.0547
Mycobacterium ulcerans dehydrogenase 0.0046 0.0582 0.0582
Brugia malayi nuclear receptor NHR-88 0.001 0.0026 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.134 0.2147
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0015 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0026 0.0041
Trypanosoma brucei polo-like protein kinase 0.0096 0.134 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0316 0.0765
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0814 0.6077
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.134 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0323 0.0781
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0046 0.0582 0.0932
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0405
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0323 0.0781
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0026 0.0041
Entamoeba histolytica hypothetical protein 0.0019 0.0167 0.1246
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0167 0.0405
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0167 0.0405
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0172 0.0416
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.141
Brugia malayi jmjC domain containing protein 0.0097 0.1356 0.3285
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.05 0.0802
Brugia malayi jmjC domain containing protein 0.001 0.0015 0.0036
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0167 0.0268
Plasmodium falciparum protoporphyrinogen oxidase 0.0046 0.0582 1
Brugia malayi MH2 domain containing protein 0.0121 0.1728 0.4188
Loa Loa (eye worm) glutaminase 0.0277 0.4127 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0011
Brugia malayi jmjC domain containing protein 0.001 0.0015 0.0036
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0015 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0026 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0167 0.0405
Brugia malayi Bromodomain containing protein 0.003 0.0323 0.0781
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0167 0.0268
Schistosoma mansoni cpg binding protein 0.0031 0.0341 0.0547
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0323 0.0517
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0418 0.067
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0026 0.0192
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0167 0.0405
Loa Loa (eye worm) hypothetical protein 0.0051 0.0647 0.1568
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0167 0.0268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0026 0.0041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0026 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0015 0.0036
Brugia malayi PHD-finger family protein 0.0011 0.0042 0.0102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0026 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0167 0.0405
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.141
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0026 0.0041
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0015 0.0024
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0167 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0062
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0167 0.0268
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0814 0.0814
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0015 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0015 0.0111
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0026 0.0041
Leishmania major hypothetical protein, conserved 0.001 0.0015 0.0111
Mycobacterium ulcerans oxidoreductase 0.0046 0.0582 0.0582
Brugia malayi hypothetical protein 0.0019 0.0167 0.0405
Onchocerca volvulus Alhambra homolog 0.003 0.0323 0.2407
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0044 0.0757
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0167 0.0268
Schistosoma mansoni hypothetical protein 0.0414 0.6241 1
Brugia malayi jmjC domain containing protein 0.0037 0.0444 0.1075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0026 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0716 0.8793
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0597 0.1446
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0323 0.3961
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0036
Schistosoma mansoni glutaminase 0.0277 0.4127 0.6613
Echinococcus granulosus expressed protein 0.0378 0.5683 0.9107
Echinococcus granulosus lysine specific histone demethylase 1A 0.0046 0.0582 0.0932
Loa Loa (eye worm) hypothetical protein 0.0046 0.0582 0.141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0128 0.0205
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0323 0.3961
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.062 0.9405 0.9405
Giardia lamblia PHD finger protein 15 0.003 0.0323 0.2407
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0167 0.0405
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0582 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0046 0.0582 0.4342
Brugia malayi ecdysteroid receptor 0.001 0.0026 0.0062
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0167 0.0268
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0026 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0172 0.0275
Brugia malayi steroid hormone receptor 0.001 0.0026 0.0062
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0167 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.134 0.3247
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0015 0.0024
Echinococcus multilocularis protoporphyrinogen oxidase 0.0046 0.0582 0.0932
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0444 0.1075
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.062 0.9405 1
Giardia lamblia Kinase, PLK 0.0096 0.134 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.004 0.0065
Trichomonas vaginalis glutaminase, putative 0.0277 0.4127 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0026 0.0062
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.004 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0026 0.0062
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0167 0.0268

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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