Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0671 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3537 | 0.3071 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3537 | 0.3537 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0671 | 0.0671 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0671 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3537 | 0.3537 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0671 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3537 | 0.3071 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0671 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0671 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3537 | 0.3071 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0671 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0671 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3537 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0671 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0119 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.