Detailed information for compound 892887

Basic information

Technical information
  • TDR Targets ID: 892887
  • Name: N-(4-carbamoylphenyl)-2-nitrobenzamide
  • MW: 285.255 | Formula: C14H11N3O4
  • H donors: 2 H acceptors: 4 LogP: 1.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1[N+](=O)[O-])Nc1ccc(cc1)C(=O)N
  • InChi: 1S/C14H11N3O4/c15-13(18)9-5-7-10(8-6-9)16-14(19)11-3-1-2-4-12(11)17(20)21/h1-8H,(H2,15,18)(H,16,19)
  • InChiKey: CRHLHAYVXATWKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-carbamoylphenyl)-2-nitro-benzamide
  • N-(4-aminocarbonylphenyl)-2-nitro-benzamide
  • BIM-0006380.P001
  • Oprea1_875167
  • CBMicro_006314
  • ZINC00435978
  • STK180691
  • Oprea1_426084

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.337 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.337 1
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0191 0.0191
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.1651 0.1651
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Echinococcus multilocularis heat shock protein 90 0.0032 0.3093 0.3093
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 1 1
Echinococcus granulosus heat shock protein 0.0032 0.3093 0.3093
Loa Loa (eye worm) hypothetical protein 0.0064 1 1
Plasmodium vivax histone deacetylase 1, putative 0.0064 1 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.337 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Mycobacterium leprae Conserved hypothetical protein 0.0034 0.337 1
Mycobacterium leprae putative cytochrome p450 0.0034 0.337 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.337 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.3093 0.3093
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Loa Loa (eye worm) heat shock protein 90 0.0032 0.3093 0.3093
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.337 1
Echinococcus multilocularis 0.0034 0.337 0.337
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.337 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.1651 0.1344
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.337 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.337 1
Plasmodium vivax endoplasmin, putative 0.0032 0.3093 0.3093
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.337 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.337 1
Toxoplasma gondii histone deacetylase HDAC2 0.0064 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.3093 0.1728
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.3093 0.3093
Echinococcus granulosus endoplasmin 0.0026 0.1651 0.1651
Schistosoma mansoni endoplasmin 0.0032 0.3093 0.3093
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Trypanosoma cruzi histone deacetylase 1, putative 0.0064 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0064 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.337 1
Echinococcus multilocularis histone deacetylase 3 0.0064 1 1
Plasmodium falciparum histone deacetylase 1 0.0064 1 1
Giardia lamblia Histone deacetylase 0.0064 1 1
Loa Loa (eye worm) histone deacetylase 3 0.0064 1 1
Echinococcus multilocularis heat shock protein 0.0032 0.3093 0.3093
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.1651 0.1651
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Echinococcus multilocularis heat shock protein 90 0.0026 0.1651 0.1651
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.337 1
Toxoplasma gondii histone deacetylase HDAC3 0.0064 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.337 0.337
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.337 0.337
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.337 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.337 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.3093 0.3093
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.337 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.337 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.337 1
Schistosoma mansoni heat shock protein 0.0032 0.3093 0.3093
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 1 1
Schistosoma mansoni histone deacetylase 0.0064 1 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.337 1
Entamoeba histolytica histone deacetylase, putative 0.0064 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.337 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.337 1
Leishmania major cytochrome p450-like protein 0.0034 0.337 0.337
Trichomonas vaginalis heat shock protein, putative 0.0026 0.1651 0.1344
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.337 1
Echinococcus granulosus histone deacetylase 1 0.0064 1 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.337 1
Brugia malayi Cytochrome P450 family protein 0.0034 0.337 0.337
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.337 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.337 1
Brugia malayi Endoplasmin precursor 0.0032 0.3093 0.3093
Trypanosoma brucei histone deacetylase 1 0.0064 1 1
Treponema pallidum heat shock protein 90 0.0026 0.1651 0.5
Trichomonas vaginalis histone deacetylase, putative 0.0064 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.3093 0.3093
Echinococcus multilocularis histone deacetylase 1 0.0064 1 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Trichomonas vaginalis heat shock protein, putative 0.0026 0.1651 0.1344
Plasmodium vivax heat shock protein 86, putative 0.0032 0.3093 0.3093
Leishmania major histone deacetylase, putative 0.0064 1 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.337 1
Brugia malayi histone deacetylase 1 (HD1) 0.0064 1 1
Echinococcus granulosus heat shock protein 90 0.0032 0.3093 0.3093
Schistosoma mansoni endoplasmin 0.0032 0.3093 0.3093
Trypanosoma cruzi histone deacetylase 1, putative 0.0064 1 1
Brugia malayi Histone deacetylase 1 0.0064 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0064 1 1
Brugia malayi Cytochrome P450 family protein 0.0034 0.337 0.337
Trichomonas vaginalis histone deacetylase, putative 0.0064 1 1
Echinococcus multilocularis endoplasmin 0.0026 0.1651 0.1651
Brugia malayi heat shock protein 90 0.0032 0.3093 0.3093
Trichomonas vaginalis histone deacetylase, putative 0.0064 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.1651 0.5
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Loa Loa (eye worm) endoplasmin 0.0032 0.3093 0.3093
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.337 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.337 0.337
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.3093 0.3093
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.3093 0.3093
Leishmania major cytochrome p450-like protein 0.0034 0.337 0.337
Schistosoma mansoni cytochrome P450 0.0034 0.337 0.337
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.337 0.337
Loa Loa (eye worm) cytochrome P450 0.0034 0.337 0.337
Loa Loa (eye worm) CYP4Cod1 0.0034 0.337 0.337
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.337 1
Leishmania major cytochrome p450-like protein 0.0034 0.337 0.337
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.337 1
Echinococcus granulosus histone deacetylase 3 0.0064 1 1
Loa Loa (eye worm) histone deacetylase 1 0.0064 1 1
Plasmodium falciparum heat shock protein 90 0.0032 0.3093 0.3093
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.337 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.3093 0.3093
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.3093 0.3093
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Trichomonas vaginalis histone deacetylase, putative 0.0064 1 1
Leishmania major histone deacetylase, putative 0.0064 1 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Schistosoma mansoni histone deacetylase 0.0064 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.337 0.337
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.337 0.337
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.337 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.337 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0064 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.337 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Brugia malayi Cytochrome P450 family protein 0.0034 0.337 0.337
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Echinococcus granulosus heat shock protein 90 0.0026 0.1651 0.1651
Trypanosoma brucei cytochrome P450, putative 0.0034 0.337 0.337
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.337 0.337
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.337 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.337 1
Brugia malayi Cytochrome P450 family protein 0.0034 0.337 0.337
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.337 0.337
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.337 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.337 1
Schistosoma mansoni hypothetical protein 0.0034 0.337 0.337
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.337 0.337
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.337 1
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.3093 0.3093
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.337 0.337
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.337 1
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.1651 0.1651
Toxoplasma gondii heat shock protein HSP90 0.0032 0.3093 0.3093
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Trichomonas vaginalis heat shock protein, putative 0.0032 0.3093 0.284
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Trypanosoma brucei heat shock protein, putative 0.0032 0.3093 0.3093
Brugia malayi cytochrome P450 0.0034 0.337 0.337
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093
Plasmodium falciparum endoplasmin, putative 0.002 0.0355 0.0355
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.337 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.1651 0.1651
Schistosoma mansoni heat shock protein 0.0032 0.3093 0.3093
Onchocerca volvulus Histone deacetylase 10 homolog 0.0018 0 0.5
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.337 0.337
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.337 0.337
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.337 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.337 1
Leishmania major heat shock protein 83-1 0.0032 0.3093 0.3093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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