TDR Targets

Basic information

Technical information

TDR Targets ID: 894509
Name: carboxymethyl-hydroxy-di(phenyl)phosphanium
MW: 260.225 | Formula: C14H13O3P
H donors: 1 H acceptors: 3 LogP: 2.09 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CP(=O)(c1ccccc1)c1ccccc1
InChi: 1S/C14H13O3P/c15-14(16)11-18(17,12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10H,11H2,(H,15,16)
InChiKey: DDTNHSJIKJRPTF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-di(phenyl)phosphorylacetic acid
carboxymethyl-hydroxy-di(phenyl)phosphonium
2-di(phenyl)phosphorylethanoic acid
1831-63-6
AF-936/31256051
CBMicro_011876
MLS000104683
SMR000054616
Diphenylphosphinylacetic acid
BIM-0012082.P001
NSC193778
(Diphenylphosphoryl)acetic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0029	0.0108	0.0091
Plasmodium vivax	acyl-CoA synthetase, putative	0.0079	0.042	0.042
Schistosoma mansoni	hexokinase	0.1622	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0193	0.0186
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0031	0.012	0.0103
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0034	0.0138	0.0111
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0031	0.0119	0.073
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0017	0.001
Loa Loa (eye worm)	hypothetical protein	0.013	0.0734	0.0718
Leishmania major	GTP-binding protein, putative	0.0016	0.0028	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Mycobacterium ulcerans	acyl-CoA synthetase	0.0106	0.0586	0.3856
Loa Loa (eye worm)	jmjC domain-containing protein	0.0055	0.0266	0.0249
Echinococcus multilocularis	pyruvate kinase	0.0031	0.0119	0.0112
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0138	0.0122
Echinococcus multilocularis	GPCR, family 2	0.0029	0.0108	0.0101
Brugia malayi	ImpB/MucB/SamB family protein	0.0079	0.0418	0.0402
Plasmodium falciparum	ataxin-2 like protein, putative	0.0045	0.0208	0.0208
Echinococcus multilocularis	geminin	0.0607	0.3698	0.3694
Echinococcus granulosus	dna polymerase kappa	0.0034	0.0138	0.0132
Trichomonas vaginalis	importin beta-1, putative	0.0018	0.0038	0.0934
Schistosoma mansoni	acetyl-CoA synthetase	0.0031	0.012	0.0103
Loa Loa (eye worm)	PHD-finger family protein	0.0026	0.0091	0.0074
Plasmodium falciparum	hexokinase	0.1622	1	1
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0239	0.1413	1
Echinococcus multilocularis	jumonji domain containing protein	0.0037	0.0155	0.0148
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0119	0.0102
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0068	0.0061
Schistosoma mansoni	hypothetical protein	0.0029	0.0108	0.0091
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0017	0.001
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0031	0.0119	0.0102
Schistosoma mansoni	cpg binding protein	0.0055	0.0267	0.0251
Giardia lamblia	Pyruvate kinase	0.0031	0.0119	0.828
Schistosoma mansoni	hypothetical protein	0.0029	0.0108	0.0091
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Entamoeba histolytica	hypothetical protein	0.0067	0.0344	0.0316
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Echinococcus granulosus	PHD finger protein rhinoceros	0.0026	0.0091	0.0084
Loa Loa (eye worm)	hexokinase	0.1622	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0073	0.0056
Schistosoma mansoni	pyruvate kinase	0.0016	0.0025	0.0008
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0031	0.012	0.0103
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0031	0.012	0.0114
Echinococcus granulosus	dnaJ subfamily B	0.0739	0.4517	0.4514
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.0193	0.0176
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0106	0.0586	0.056
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0068	0.3745
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0031	0.012	0.0103
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0026	0.0091	0.0074
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0056	0.0272	0.0255
Trichomonas vaginalis	antibiotic synthetase, putative	0.0031	0.012	0.8363
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.012	0.0103
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.012	0.0103
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0239	0.1413	0.1413
Schistosoma mansoni	hypothetical protein	0.0026	0.0091	0.0074
Leishmania major	DNA polymerase eta, putative	0.0079	0.0418	0.0402
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0031	0.012	0.0103
Trypanosoma brucei	pyruvate kinase 1, putative	0.0031	0.0119	0.0102
Onchocerca volvulus		0.0031	0.012	0.003
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0031	0.012	0.0391
Entamoeba histolytica	hexokinase 2	0.1622	1	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0068	0.0051
Mycobacterium ulcerans	DNA polymerase IV	0.0034	0.0138	0.0526
Loa Loa (eye worm)	histone methyltransferase	0.0016	0.0026	0.0009
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0031	0.012	0.0011
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0029	0.0108	0.0101
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0018	0.0038	0.0934
Loa Loa (eye worm)	pyruvate kinase	0.0031	0.0119	0.0102
Schistosoma mansoni	pyruvate kinase	0.0031	0.0119	0.0102
Onchocerca volvulus	Hexokinase homolog	0.1017	0.6246	0.6212
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0031	0.012	0.0011
Schistosoma mansoni	hypothetical protein	0.0237	0.1397	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0318	0.0302
Echinococcus multilocularis	importin subunit beta 1	0.0022	0.0064	0.0058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0193	0.0186
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0106	0.0586	0.3856
Trypanosoma brucei	unspecified product	0.0024	0.0073	0.0056
Treponema pallidum	hexokinase (hxk)	0.1622	1	1
Treponema pallidum	hypothetical protein	0.0239	0.1413	0.1354
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0075	0.0393	0.2691
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0079	0.042	0.0403
Loa Loa (eye worm)	pyruvate kinase-PB	0.0022	0.0061	0.0044
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0068	0.0061
Loa Loa (eye worm)	pyruvate kinase	0.0031	0.0119	0.0102
Echinococcus multilocularis	pyruvate kinase	0.0024	0.0079	0.0072
Trypanosoma brucei	pyruvate kinase 1	0.0031	0.0119	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0031	0.012	0.0103
Echinococcus granulosus	importin subunit beta 1	0.0022	0.0064	0.0058
Onchocerca volvulus	Pyruvate kinase homolog	0.0031	0.0119	0.0028
Brugia malayi	Latrophilin receptor protein 2	0.0029	0.0108	0.0091
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.012	0.074
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0031	0.012	0.0391
Trichomonas vaginalis	antibiotic synthetase, putative	0.0031	0.012	0.8363
Loa Loa (eye worm)	hexokinase	0.1017	0.6246	0.624
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0068	0.0051
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0068	0.0051
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0092	0.05	0.0483
Brugia malayi	AMP-binding enzyme family protein	0.0106	0.0586	0.057
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.011	0.061	0.0594
Brugia malayi	Hexokinase family protein	0.0502	0.3044	0.3032
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0031	0.012	0.0391
Mycobacterium ulcerans	hypothetical protein	0.0106	0.0586	0.3856
Schistosoma mansoni	ap endonuclease	0.0023	0.0068	0.0051
Echinococcus multilocularis	pyruvate kinase	0.0016	0.0025	0.0019
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0106	0.0586	0.3856
Leishmania major	4-coumarate:coa ligase-like protein	0.0106	0.0586	0.057
Leishmania major	hexokinase, putative	0.1622	1	1
Mycobacterium ulcerans	DNA polymerase IV	0.0034	0.0138	0.0526
Entamoeba histolytica	pyruvate kinase, putative	0.0022	0.0061	0.0033
Echinococcus granulosus	peregrin	0.0026	0.0091	0.0084
Brugia malayi	latrophilin 2 splice variant baaae	0.0063	0.0318	0.0302
Echinococcus granulosus	pyruvate kinase	0.0031	0.0119	0.0112
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Brugia malayi	Muscleblind-like protein	0.013	0.0734	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0079	0.042	0.0403
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1507	0.929	0.9289
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0029	0.0108	0.0101
Echinococcus multilocularis	lysine specific demethylase 5A	0.0032	0.0125	0.0119
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0016	0.0026	0.002
Echinococcus multilocularis	hexokinase type 2	0.1622	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0106	0.0586	0.3856
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0031	0.012	0.0103
Trypanosoma brucei	hexokinase	0.1622	1	1
Brugia malayi	Hexokinase family protein	0.1017	0.6246	0.624
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0031	0.0119	0.0102
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0031	0.012	0.0103
Giardia lamblia	PHD finger protein 15	0.0026	0.0091	0.5786
Plasmodium falciparum	importin beta, putative	0.0022	0.0064	0.0064
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0144	0.0127
Mycobacterium ulcerans	acyl-CoA synthetase	0.0106	0.0586	0.3856
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0034	0.0138	0.0869
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0031	0.012	0.0114
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0239	0.1413	1
Schistosoma mansoni	ap endonuclease	0.0023	0.0068	0.0051
Plasmodium vivax	pyruvate kinase, putative	0.0031	0.0119	0.0119
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0031	0.012	0.074
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0075	0.0393	0.2691
Toxoplasma gondii	propionate-CoA ligase	0.0031	0.012	0.0103
Schistosoma mansoni	hypothetical protein	0.0607	0.3698	0.3687
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Mycobacterium ulcerans	acyl-CoA synthetase	0.0106	0.0586	0.3856
Trypanosoma cruzi	DNA polymerase eta, putative	0.0056	0.0272	0.0255
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0031	0.012	0.012
Brugia malayi	hexokinase type II	0.0516	0.3129	0.3118
Plasmodium falciparum	pyruvate kinase 2	0.0016	0.0025	0.0025
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0017	0.0017
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.012	0.074
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.012	0.0103
Leishmania major	pyruvate kinase	0.0031	0.0119	0.0102
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.012	0.074
Toxoplasma gondii	LsmAD domain-containing protein	0.0045	0.0208	0.0191
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0073	0.0056
Echinococcus multilocularis	hexokinase	0.1622	1	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0031	0.0119	0.0028
Brugia malayi	F/Y-rich N-terminus family protein	0.0024	0.0079	0.0062
Schistosoma mansoni	cpg binding protein	0.0055	0.0267	0.0251
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0034	0.0138	0.0122
Onchocerca volvulus		0.0031	0.012	0.003
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0068	0.3595
Trypanosoma brucei	hexokinase	0.1622	1	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0079	0.0418	0.0402
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.002	0.0053	0.0046
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0031	0.012	0.074
Loa Loa (eye worm)	hypothetical protein	0.0279	0.1657	0.1643
Schistosoma mansoni	cpg binding protein	0.0052	0.0249	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0031	0.012	0.0103
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.012	0.0103
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Onchocerca volvulus		0.0031	0.012	0.003
Schistosoma mansoni	DNA polymerase eta	0.0079	0.0418	0.0402
Echinococcus granulosus	pyruvate kinase	0.0016	0.0025	0.0019
Echinococcus multilocularis	dna polymerase kappa	0.0034	0.0138	0.0132
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0031	0.012	0.074
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0034	0.0138	0.0132
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0087	0.0464	0.0458
Echinococcus multilocularis	muscleblind protein	0.013	0.0734	0.0727
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0016	0.0028	0.0021
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0031	0.012	0.0391
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0068	0.3595
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0068	0.0051
Schistosoma mansoni	hypothetical protein	0.0063	0.0318	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0586	0.057
Schistosoma mansoni	pyruvate kinase	0.0031	0.0119	0.0102
Echinococcus granulosus	hexokinase	0.1622	1	1
Echinococcus granulosus	muscleblind protein	0.013	0.0734	0.0727
Trypanosoma cruzi	PAB1-binding protein , putative	0.0045	0.0208	0.0191
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0031	0.012	0.0391
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0106	0.0586	0.056
Plasmodium vivax	importin-beta 2, putative	0.0022	0.0064	0.0064
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0031	0.012	0.0011
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0016	0.0028	0.0028
Onchocerca volvulus	Pyruvate kinase homolog	0.0031	0.0119	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0516	0.3129	0.3118
Mycobacterium ulcerans	pyruvate kinase	0.0031	0.0119	0.0381
Brugia malayi	jmjC domain containing protein	0.0087	0.0464	0.0448
Plasmodium vivax	pyruvate kinase 2, putative	0.0016	0.0025	0.0025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0193	0.0176
Toxoplasma gondii	pyruvate kinase PyK1	0.0031	0.0119	0.0102
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0016	0.0028	0.0233
Echinococcus granulosus	snurportin 1	0.0237	0.1397	0.1391
Loa Loa (eye worm)	oxidoreductase	0.0031	0.012	0.0103
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0029	0.0108	0.0101
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0106	0.0586	0.4079
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0068	0.0068
Giardia lamblia	DINP protein human, muc B family	0.0034	0.0138	1
Brugia malayi	AMP-binding enzyme family protein	0.0106	0.0586	0.057
Brugia malayi	jmjC domain containing protein	0.0035	0.0144	0.0127
Onchocerca volvulus		0.1017	0.6246	0.6212
Onchocerca volvulus		0.1622	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0073	0.0056
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0016	0.0028	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0586	0.057
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0138	0.0122
Loa Loa (eye worm)	hexokinase	0.1622	1	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0022	0.0064	0.0047
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0093	0.0547
Trypanosoma cruzi	PAB1-binding protein , putative	0.0045	0.0208	0.0191
Echinococcus multilocularis	cpg binding protein	0.0055	0.0267	0.0261
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.012	0.0103
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0034	0.0138	0.0122
Brugia malayi	RNA, U transporter 1	0.0063	0.0318	0.0302
Leishmania major	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0087	0.0464	0.0458
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0068	0.0051
Echinococcus granulosus	hexokinase	0.1622	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0106	0.0586	0.057
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0079	0.042	0.2884
Onchocerca volvulus		0.1622	1	1
Leishmania major	acetyl-CoA synthetase, putative	0.0031	0.012	0.0103
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0144	0.0127
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0017	0.0017
Trypanosoma cruzi	hexokinase, putative	0.1622	1	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0068	0.5
Onchocerca volvulus		0.1622	1	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0022	0.0064	0.0047
Brugia malayi	CXXC zinc finger family protein	0.0052	0.0249	0.0232
Brugia malayi	ImpB/MucB/SamB family protein	0.0034	0.0138	0.0122
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0031	0.012	0.0391
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0138	0.0122
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0031	0.012	0.0093
Echinococcus multilocularis	snurportin 1	0.0237	0.1397	0.1391
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0017	0.001
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0418	0.0402
Brugia malayi	PHD-finger family protein	0.0026	0.0091	0.0074
Leishmania major	hexokinase, putative	0.1622	1	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0016	0.0028	0.0021
Echinococcus granulosus	hexokinase	0.1622	1	1
Brugia malayi	Bromodomain containing protein	0.0026	0.0091	0.0074
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0106	0.0586	0.3612
Loa Loa (eye worm)	hypothetical protein	0.013	0.0734	0.0718
Plasmodium falciparum	phd finger protein, putative	0.0026	0.0091	0.0091
Entamoeba histolytica	hypothetical protein	0.0067	0.0344	0.0316
Leishmania major	importin beta-1 subunit, putative	0.0018	0.0038	0.0021
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0067	0.0344	0.0337
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0092	0.05	0.0483
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Plasmodium vivax	hexokinase, putative	0.1622	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0075	0.0393	0.2691
Loa Loa (eye worm)	hypothetical protein	0.0092	0.05	0.0483
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0022	0.006	0.0043
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0144	0.0127
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0092	0.05	0.0483
Plasmodium falciparum	ataxin-2 like protein, putative	0.0045	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.1106	0.6797	0.6792
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0016	0.0028	0.0011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Echinococcus granulosus	pyruvate kinase	0.0031	0.0119	0.0112
Schistosoma mansoni	hypothetical protein	0.002	0.0053	0.0036
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0017	0.001
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0031	0.012	0.074
Schistosoma mansoni	hypothetical protein	0.0029	0.0108	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0208	0.0191
Leishmania major	acetyl-CoA synthetase, putative	0.0031	0.012	0.0103
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0034	0.0138	0.0122
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0016	0.0028	0.0011
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0068	0.0363
Loa Loa (eye worm)	pyruvate kinase	0.0031	0.0119	0.0102
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0018	0.0038	0.0934
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0031	0.012	0.0103
Toxoplasma gondii	PHD-finger domain-containing protein	0.0026	0.0091	0.0074
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0029	0.0108	0.0091
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0031	0.0119	0.0102
Entamoeba histolytica	acyl-coA synthetase, putative	0.0106	0.0586	0.056
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0031	0.0119	0.0102
Loa Loa (eye worm)	hexokinase	0.0502	0.3044	0.3032
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0031	0.012	0.0103
Loa Loa (eye worm)	hexokinase type II	0.1622	1	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0144	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0079	0.042	0.0403
Echinococcus granulosus	jumonji domain containing protein	0.0037	0.0155	0.0148
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0029	0.0108	0.0101
Entamoeba histolytica	hexokinase 1	0.1622	1	1
Brugia malayi	Importin beta-1 subunit	0.0022	0.0064	0.0047
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0031	0.012	0.012
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0017	0.001
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0031	0.012	0.0391
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0106	0.0586	0.4079
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0034	0.0138	0.0869
Trichomonas vaginalis	DNA polymerase eta, putative	0.0034	0.0138	1
Echinococcus multilocularis	pyruvate kinase	0.0016	0.0025	0.0019
Trypanosoma brucei	unspecified product	0.0024	0.0073	0.0056
Toxoplasma gondii	hexokinase	0.1622	1	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0079	0.0418	0.0402
Entamoeba histolytica	hypothetical protein	0.0067	0.0344	0.0316
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Brugia malayi	hypothetical protein	0.0045	0.0208	0.0191
Plasmodium falciparum	acyl-CoA synthetase	0.0079	0.042	0.042
Schistosoma mansoni	ran	0.0016	0.0028	0.0011
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0068	0.0051
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0079	0.042	0.2616
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0237	0.1397	0.1382
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0193	0.0176
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0031	0.012	0.0103
Echinococcus granulosus	GPCR family 2	0.0029	0.0108	0.0101
Plasmodium vivax	ataxin-2 like protein, putative	0.0045	0.0208	0.0208
Echinococcus multilocularis	peregrin	0.0026	0.0091	0.0084
Entamoeba histolytica	hypothetical protein	0.0018	0.0038	0.001
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0016	0.0028	0.0011
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.012	0.0103
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0018	0.0038	0.0021
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.012	0.074
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0031	0.012	0.074
Brugia malayi	Hexokinase family protein	0.1622	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0586	0.057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0193	0.0186
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0075	0.0393	0.2691
Echinococcus multilocularis	hexokinase	0.1622	1	1
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0239	0.1413	1
Schistosoma mansoni	hypothetical protein	0.0067	0.0344	0.0327
Echinococcus granulosus	geminin	0.0607	0.3698	0.3694
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0016	0.0026	0.002
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0034	0.0138	0.0122
Echinococcus granulosus	dna polymerase eta	0.0079	0.0418	0.0412
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.0193	0.0176
Toxoplasma gondii	exonuclease III APE	0.0023	0.0068	0.0051
Plasmodium falciparum	pyruvate kinase	0.0031	0.0119	0.0119
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0052	0.0249	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0079	0.042	0.0403
Trypanosoma cruzi	hexokinase, putative	0.1622	1	1
Leishmania major	DNA polymerase eta, putative	0.0056	0.0272	0.0255
Leishmania major	4-coumarate:coa ligase-like protein	0.0106	0.0586	0.057
Toxoplasma gondii	pyruvate kinase PyKII	0.0016	0.0025	0.0008
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0034	0.0138	0.0132
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0193	0.0186
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0516	0.3129	0.3118
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0098	0.0537	0.0521
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0031	0.012	0.0391
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Echinococcus multilocularis	dna polymerase eta	0.0079	0.0418	0.0412
Schistosoma mansoni	transcription factor LCR-F1	0.0067	0.0344	0.0327
Toxoplasma gondii	PHD-finger domain-containing protein	0.0026	0.0091	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0079	0.042	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0064	0.0047
Leishmania major	4-coumarate:coa ligase-like protein	0.0106	0.0586	0.057
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0091	0.0074
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0031	0.012	0.0391
Echinococcus granulosus	pyruvate kinase	0.0016	0.0025	0.0019
Leishmania major	pyruvate kinase	0.0031	0.0119	0.0102
Echinococcus multilocularis	pyruvate kinase	0.0031	0.0119	0.0112
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0016	0.0028	0.0011
Trypanosoma brucei	importin beta-1 subunit, putative	0.0022	0.0064	0.0047
Echinococcus granulosus	pyruvate kinase	0.0016	0.0025	0.0019
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0091	0.0091
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.012	0.0391
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0031	0.012	0.074
Trichomonas vaginalis	pyruvate kinase, putative	0.0031	0.0119	0.8238
Schistosoma mansoni	importin beta-1	0.0022	0.0064	0.0047
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0031	0.012	0.074
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0068	0.004
Echinococcus granulosus	cpg binding protein	0.0055	0.0267	0.0261
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Echinococcus multilocularis	pyruvate kinase	0.0016	0.0025	0.0019
Echinococcus granulosus	hexokinase type 2	0.1622	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0108	0.0091
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0239	0.1413	0.1413
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0106	0.0586	0.3856
Onchocerca volvulus		0.0279	0.1657	0.158
Schistosoma mansoni	hypothetical protein	0.0607	0.3698	0.3687
Schistosoma mansoni	jumonji domain containing protein	0.0069	0.0354	0.0337
Schistosoma mansoni	hypothetical protein	0.0029	0.0108	0.0091
Entamoeba histolytica	hypothetical protein	0.0067	0.0344	0.0316
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0079	0.042	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0016	0.0028	0.0011
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.002	0.0053	0.0046
Brugia malayi	hypothetical protein	0.0279	0.1657	0.1643
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.012	0.0103
Onchocerca volvulus		0.0106	0.0586	0.05
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0193	0.0176
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0067	0.0344	0.0337
Echinococcus multilocularis	dnaJ subfamily B	0.0739	0.4517	0.4514
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0138	0.0122
Trypanosoma brucei	hexokinase, putative	0.1622	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0045	0.0208	0.0191
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0026	0.0091	0.0084
Onchocerca volvulus		0.0052	0.0249	0.016
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0016	0.0028	0.0028
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0029	0.0108	0.0091
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0068	0.0068
Echinococcus multilocularis	muscleblind protein 1	0.013	0.0734	0.0727
Onchocerca volvulus		0.0031	0.012	0.003
Schistosoma mansoni	hypothetical protein	0.0739	0.4517	0.4508
Schistosoma mansoni	ran	0.0016	0.0028	0.0011
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0017	0.001
Trichomonas vaginalis	pyruvate kinase, putative	0.0031	0.0119	0.8238
Brugia malayi	hypothetical protein	0.0067	0.0344	0.0327
Echinococcus multilocularis	hexokinase	0.1622	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0061	0.0044
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0106	0.0586	0.3612
Leishmania major	hypothetical protein, conserved	0.0045	0.0208	0.0191
Trypanosoma brucei	unspecified product	0.0034	0.0138	0.0122
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.012	0.0103
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0034	0.0138	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0208	0.0191

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	66.6 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	100 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.0002 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)]	ChEMBL.	No reference
Potency (functional)	100 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1567605
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 894509