Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2312 | 0.367 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.5922 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5922 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2312 | 0.367 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5922 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.0035 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.5922 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.5922 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5922 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.5922 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2312 | 0.367 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.5922 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2312 | 0.367 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.5922 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.5922 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.5922 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2312 | 0.367 | 0.3639 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5922 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2312 | 0.367 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.5922 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.5922 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.