Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.003 | 0.0153 | 0.0138 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0153 | 0.0138 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0053 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0153 | 0.0138 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0053 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0015 | 0.0015 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0053 | 0.0038 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0262 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0053 | 0.0053 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Schistosoma mansoni | jumonji domain containing protein | 0.0066 | 0.054 | 0.0526 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0053 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0159 | 0.1543 | 0.1531 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0015 | 0.0015 |
Onchocerca volvulus | 0.0159 | 0.1543 | 0.4148 | |
Echinococcus multilocularis | geminin | 0.019 | 0.1888 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0015 | 0.0015 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0939 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0262 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0262 | 0.0248 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.3506 | 0.3506 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0053 | 0.0038 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0066 | 0.054 | 0.0526 |
Onchocerca volvulus | 0.034 | 0.3506 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.1888 | 0.1876 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0066 | 0.054 | 0.0526 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Onchocerca volvulus | 0.0159 | 0.1543 | 0.4148 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0939 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0153 | 0.0138 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0053 | 0.0038 |
Brugia malayi | jmjC domain containing protein | 0.0066 | 0.054 | 0.054 |
Brugia malayi | hypothetical protein | 0.004 | 0.0262 | 0.0262 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0053 | 0.0053 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0262 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0159 | 0.1543 | 0.1531 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0153 | 0.0153 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0053 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.0153 | 0.0138 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0939 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0939 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0939 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0939 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0015 | 0.0015 |
Echinococcus multilocularis | acetylcholinesterase | 0.0939 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0159 | 0.1543 | 0.1531 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.1888 | 0.1876 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0053 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0053 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0066 | 0.054 | 0.0526 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0153 | 0.0138 |
Echinococcus granulosus | geminin | 0.019 | 0.1888 | 0.1876 |
Onchocerca volvulus | 0.0159 | 0.1543 | 0.4148 | |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.052 | 0.5457 | 0.545 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Brugia malayi | Carboxylesterase family protein | 0.0159 | 0.1543 | 0.1543 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0159 | 0.1543 | 1 |
Echinococcus multilocularis | lamin | 0.003 | 0.0153 | 0.0138 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0262 | 0.0248 |
Schistosoma mansoni | acetylcholinesterase | 0.0159 | 0.1543 | 0.1531 |
Onchocerca volvulus | 0.0159 | 0.1543 | 0.4148 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0159 | 0.1543 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0015 | 0.0015 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0153 | 0.0153 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0066 | 0.054 | 0.0526 |
Echinococcus multilocularis | neuropeptide s receptor | 0.052 | 0.5457 | 0.545 |
Schistosoma mansoni | lamin | 0.003 | 0.0153 | 0.0138 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0015 | 0.0015 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0159 | 0.1543 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0066 | 0.054 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0147 | 0.0147 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0066 | 0.054 | 0.0526 |
Onchocerca volvulus | 0.0159 | 0.1543 | 0.4148 | |
Schistosoma mansoni | gliotactin | 0.0159 | 0.1543 | 0.1531 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0159 | 0.1543 | 1 |
Brugia malayi | hypothetical protein | 0.034 | 0.3506 | 0.3506 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0262 | 0.0248 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0018 | 0.0015 | 0.0015 |
Echinococcus granulosus | neuroligin | 0.0159 | 0.1543 | 0.1531 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0053 | 0.0038 |
Loa Loa (eye worm) | carboxylesterase | 0.0159 | 0.1543 | 0.1543 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0159 | 0.1543 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Brugia malayi | Carboxylesterase family protein | 0.0159 | 0.1543 | 0.1543 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0153 | 0.0153 |
Echinococcus granulosus | acetylcholinesterase | 0.0939 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0159 | 0.1543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0153 | 0.0153 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0053 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0939 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.052 | 0.5457 | 0.545 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0159 | 0.1543 | 0.1531 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0262 | 0.0248 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0015 | 0.0015 |
Brugia malayi | jmjC domain containing protein | 0.0018 | 0.0015 | 0.0015 |
Echinococcus granulosus | acetylcholinesterase | 0.0939 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.052 | 0.5457 | 0.545 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0262 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0066 | 0.054 | 0.0526 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0159 | 0.1543 | 0.1531 |
Brugia malayi | Carboxylesterase family protein | 0.0159 | 0.1543 | 0.1543 |
Brugia malayi | Carboxylesterase family protein | 0.0159 | 0.1543 | 0.1543 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0053 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0153 | 0.0153 |
Brugia malayi | Carboxylesterase family protein | 0.0939 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Loa Loa (eye worm) | carboxylesterase | 0.0159 | 0.1543 | 0.1543 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0053 | 1 |
Brugia malayi | hypothetical protein | 0.0159 | 0.1543 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0015 | 0.0015 |
Echinococcus multilocularis | neuroligin | 0.0159 | 0.1543 | 0.1531 |
Echinococcus multilocularis | musashi | 0.003 | 0.0153 | 0.0138 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0066 | 0.054 | 0.054 |
Echinococcus multilocularis | acetylcholinesterase | 0.0939 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.