Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0284 | 0.9705 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0913 | 0.0941 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0913 | 0.0941 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0284 | 0.9705 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0014 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0115 | 0.3614 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0111 | 0.3479 | 0.3585 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0913 | 0.0941 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.004 | 0.0913 | 0.0941 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0104 | 0.322 | 0.3157 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0041 | 0.0961 | 0.2246 |
Leishmania major | trypanothione reductase | 0.0041 | 0.0961 | 0.099 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0284 | 0.9705 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0104 | 0.322 | 0.3317 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.002 | 0.0228 | 0.0235 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0093 | 0.2845 | 0.2932 |
Toxoplasma gondii | thioredoxin reductase | 0.0041 | 0.0961 | 0.099 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0043 | 0.1041 | 0.1073 |
Trypanosoma brucei | trypanothione reductase | 0.0041 | 0.0961 | 0.099 |
Schistosoma mansoni | inositol monophosphatase | 0.0032 | 0.0639 | 0.0659 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0115 | 0.3614 | 0.3614 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0011 | 0.0012 |
Brugia malayi | AMP-binding enzyme family protein | 0.002 | 0.0228 | 0.0235 |
Brugia malayi | Inositol-1 | 0.0032 | 0.0639 | 0.0659 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0032 | 0.0639 | 0.0639 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0015 | 0.0041 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0093 | 0.2845 | 0.2932 |
Onchocerca volvulus | 0.0043 | 0.1029 | 1 | |
Brugia malayi | glutathione reductase | 0.0041 | 0.0961 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.055 | 0.1243 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1029 | 0.2411 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0115 | 0.3614 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.002 | 0.0228 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1041 | 0.2441 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0228 | 0.0235 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0284 | 0.9705 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0284 | 0.9705 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0032 | 0.0639 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0228 | 0.0455 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0093 | 0.2845 | 0.2762 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.002 | 0.0228 | 0.0235 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0032 | 0.0639 | 0.1768 |
Schistosoma mansoni | inositol monophosphatase | 0.0032 | 0.0639 | 0.0659 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0093 | 0.2845 | 0.2932 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0015 | 0.0041 | 0.0043 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0104 | 0.322 | 0.3317 |
Loa Loa (eye worm) | inositol-1 | 0.0032 | 0.0639 | 0.146 |
Loa Loa (eye worm) | glutathione reductase | 0.0041 | 0.0961 | 0.2246 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0032 | 0.0639 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0228 | 0.0455 |
Echinococcus multilocularis | muscleblind protein | 0.0129 | 0.4137 | 0.4137 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0111 | 0.3479 | 0.3585 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0284 | 0.9705 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.002 | 0.0228 | 0.0235 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0284 | 0.9705 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0093 | 0.2845 | 0.2932 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0032 | 0.0639 | 0.1215 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0043 | 0.1041 | 0.2441 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0115 | 0.3614 | 0.3614 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0015 | 0.0041 | 0.0043 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.0913 | 0.0913 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0111 | 0.3479 | 0.9626 |
Brugia malayi | AMP-binding enzyme family protein | 0.002 | 0.0228 | 0.0235 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0041 | 0.0961 | 0.099 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0115 | 0.3614 | 0.3614 |
Brugia malayi | Muscleblind-like protein | 0.0129 | 0.4137 | 0.4262 |
Plasmodium falciparum | thioredoxin reductase | 0.0041 | 0.0961 | 0.099 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.0913 | 0.0913 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.002 | 0.0228 | 0.0235 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0032 | 0.0639 | 0.0659 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.002 | 0.0228 | 0.0235 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.0913 | 0.0913 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0011 | 0.0012 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0043 | 0.1029 | 0.106 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0041 | 0.0961 | 0.099 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.004 | 0.0913 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0228 | 0.0455 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0029 | 0.0519 | 0.0307 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0111 | 0.3479 | 0.9626 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4137 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.0913 | 0.0913 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0284 | 0.9705 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.002 | 0.0228 | 0.0235 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0284 | 0.9705 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.002 | 0.0228 | 0.0235 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0093 | 0.2845 | 0.2932 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0015 | 0.0041 | 0.0043 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0032 | 0.0639 | 0.0659 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0043 | 0.1041 | 0.1073 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0284 | 0.9705 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0032 | 0.0639 | 0.0659 |
Plasmodium vivax | glutathione reductase, putative | 0.0041 | 0.0961 | 0.099 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0111 | 0.3479 | 0.9626 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0111 | 0.3479 | 0.9626 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0029 | 0.0519 | 0.0535 |
Echinococcus multilocularis | tumor protein p63 | 0.0292 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.055 | 0.0567 |
Mycobacterium ulcerans | hypothetical protein | 0.002 | 0.0228 | 0.0235 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0041 | 0.0961 | 0.0961 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0284 | 0.9705 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0015 | 0.0041 | 0.0043 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0032 | 0.0639 | 0.1768 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0011 | 0.0012 |
Treponema pallidum | NADH oxidase | 0.0014 | 0 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0032 | 0.0639 | 0.0659 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0041 | 0.0961 | 0.099 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0104 | 0.322 | 0.3317 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0032 | 0.0639 | 0.0639 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0284 | 0.9705 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0284 | 0.9705 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.002 | 0.0228 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4137 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0011 | 0.0012 |
Plasmodium falciparum | glutathione reductase | 0.0041 | 0.0961 | 0.099 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0041 | 0.0961 | 0.0961 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0115 | 0.3614 | 0.3614 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0115 | 0.3614 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0093 | 0.2845 | 0.2932 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0284 | 0.9705 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.002 | 0.0228 | 0.0235 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0032 | 0.0639 | 0.0659 |
Echinococcus granulosus | muscleblind protein | 0.0129 | 0.4137 | 0.4137 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0228 | 0.0235 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0032 | 0.0639 | 0.1768 |
Brugia malayi | Thioredoxin reductase | 0.0041 | 0.0961 | 0.099 |
Leishmania major | dihydroorotate dehydrogenase | 0.0284 | 0.9705 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.055 | 0.0567 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0129 | 0.4137 | 0.4137 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.002 | 0.0228 | 0.0235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.