Detailed information for compound 894811

Basic information

Technical information
  • TDR Targets ID: 894811
  • Name: (5Z)-5-[(3-fluorophenyl)methylidene]-2-(pyrid in-3-ylamino)-1,3-thiazol-4-one
  • MW: 299.323 | Formula: C15H10FN3OS
  • H donors: 1 H acceptors: 2 LogP: 2.86 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)/C=C/1\SC(=NC1=O)Nc1cccnc1
  • InChi: 1S/C15H10FN3OS/c16-11-4-1-3-10(7-11)8-13-14(20)19-15(21-13)18-12-5-2-6-17-9-12/h1-9H,(H,18,19,20)/b13-8-
  • InChiKey: ALBKHQUDALGCBR-JYRVWZFOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z)-5-[(3-fluorophenyl)methylene]-2-(3-pyridylamino)thiazol-4-one
  • (5Z)-5-[(3-fluorophenyl)methylene]-2-(3-pyridylamino)-4-thiazolone
  • (5Z)-5-(3-fluorobenzylidene)-2-(3-pyridylamino)thiazol-4-one
  • ZINC01006949
  • BIM-0009115.P001
  • 5-[1-(3-Fluoro-phenyl)-meth-(Z)-ylidene]-2-(pyridin-3-ylamino)-thiazol-4-one
  • MLS000333695
  • SMR000437833

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0583 0.1749
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0023 0.0191 0.0296
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0101 0.0085
Schistosoma mansoni patched 1 0.0046 0.0677 0.0661
Brugia malayi Peptidase family M1 containing protein 0.0126 0.2349 0.357
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.005 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0809 0.1058
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0088 0.156 0.2091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.1155 0.1735
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0341 0.0325
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Onchocerca volvulus 0.0035 0.0442 0.1742
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.2229 0.5951
Echinococcus multilocularis low density lipoprotein receptor protein 0.0016 0.005 0.0033
Echinococcus multilocularis expressed conserved protein 0.0101 0.1815 0.1801
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0494 0.1463
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.0312
Schistosoma mansoni hypothetical protein 0.003 0.0341 0.0325
Echinococcus granulosus low density lipoprotein receptor ldl 0.0016 0.005 0.0033
Trichomonas vaginalis immunophilin, putative 0.0165 0.3145 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0088 0.156 0.2091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.047 0.0454
Trichomonas vaginalis fk506-binding protein, putative 0.0023 0.0191 0.0489
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Onchocerca volvulus 0.0016 0.005 0.0045
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0583 0.1749
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0809 0.209
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0165 0.3145 1
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0341 0.0325
Echinococcus granulosus basement membrane specific heparan sulfate 0.0016 0.005 0.0033
Leishmania major histone deacetylase, putative 0.0041 0.0583 0.0747
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0579 0.0742
Brugia malayi Cell death protein 3 precursor 0.003 0.0341 0.0519
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0489 0.1221
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.182 0.2767
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0579 0.0742
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0023 0.0191 0.0291
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0583 0.1749
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.047 0.0454
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Giardia lamblia Methionine aminopeptidase 0.0088 0.156 0.4794
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0139 0.0321
Loa Loa (eye worm) hypothetical protein 0.0055 0.087 0.1301
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0579 0.1737
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.2229 0.5951
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0023 0.0191 0.2087
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0165 0.3145 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.3718 1
Leishmania major trypanothione reductase 0.0053 0.082 0.1073
Plasmodium falciparum thioredoxin reductase 0.0018 0.0101 0.0198
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.1155 0.1756
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.004 0.0035
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3312 0.4501
Echinococcus granulosus muscleblind protein 0.033 0.6579 0.6573
Brugia malayi CHE-14 protein 0.0046 0.0677 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.003 0.034 0.0968
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0101 0.0198
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0101 0.0167
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0809 0.3114
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0533 0.159
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0787 0.1028
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0101 0.0085
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Loa Loa (eye worm) hypothetical protein 0.033 0.6579 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.2229 0.5951
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0023 0.0191 0.0266
Trichomonas vaginalis fk506 binding protein, putative 0.0023 0.0191 0.0489
Loa Loa (eye worm) hypothetical protein 0.0142 0.2674 0.4049
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0809 0.209
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.1341 0.2038
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0016 0.005 0.0033
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.195 0.6153
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0016 0.005 0.0033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0489 0.1221
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0101 0.0167
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0088 0.156 0.1546
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0101 0.0154
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0533 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.182 0.1806
Loa Loa (eye worm) initiation factor 2-associated protein 0.0088 0.156 0.2352
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0662 0.2005
Loa Loa (eye worm) hypothetical protein 0.0089 0.1575 0.2374
Schistosoma mansoni hypothetical protein 0.0044 0.0643 0.0627
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3312 0.4501
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0023 0.0191 0.0266
Echinococcus multilocularis caspase 2 0.003 0.0341 0.0325
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.195 0.2965
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.3145 0.3133
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0489
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.2229 0.8866
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.182 0.2748
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0677 0.0661
Onchocerca volvulus Arrow homolog 0.0016 0.005 0.0045
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Loa Loa (eye worm) hypothetical protein 0.0023 0.0191 0.0266
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0016 0.005 0.0033
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.004 0.006
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0023 0.0191 0.0209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0101 0.0085
Mycobacterium tuberculosis Probable reductase 0.0121 0.2229 0.5951
Echinococcus multilocularis cpg binding protein 0.0037 0.0483 0.0467
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0023 0.0191 0.0291
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.3145 0.3133
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0088 0.156 0.4897
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0787 0.1028
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0489
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0583 0.1749
Loa Loa (eye worm) oxidoreductase 0.0015 0.004 0.0035
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0023 0.0191 0.0998
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0494 0.0625
Trichomonas vaginalis conserved hypothetical protein 0.003 0.034 0.0968
Schistosoma mansoni hypothetical protein 0.0023 0.0191 0.0175
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0033
Echinococcus multilocularis chromobox protein 1 0.0075 0.1283 0.1268
Onchocerca volvulus 0.0023 0.0191 0.0657
Echinococcus granulosus FK506 binding protein 2 0.0023 0.0191 0.0175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.2091 0.3178
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0088 0.156 0.2091
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0101 0.0085
Entamoeba histolytica methionine aminopeptidase, putative 0.0088 0.156 0.4897
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.3145 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0809 0.1206
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0596 0.1791
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0583 0.0747
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0809 0.209
Onchocerca volvulus 0.0016 0.005 0.0045
Onchocerca volvulus 0.0016 0.005 0.0045
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0583 0.1749
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.3145 0.4271
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0023 0.0191 0.0489
Loa Loa (eye worm) inositol-1 0.0041 0.0579 0.0857
Schistosoma mansoni hypothetical protein 0.0036 0.047 0.0454
Schistosoma mansoni hypothetical protein 0.0494 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0787 0.1028
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0088 0.156 0.6585
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0023 0.0191 0.0291
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0494 0.0751
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0579 0.1737
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0809 0.1229
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0489 0.182
Brugia malayi TAR-binding protein 0.0069 0.1155 0.1756
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0494 0.0625
Schistosoma mansoni histone deacetylase 0.0041 0.0583 0.0567
Echinococcus granulosus histone deacetylase 3 0.0041 0.0583 0.0567
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0442 0.0648
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0088 0.156 0.2091
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0088 0.156 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.3145 1
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0016 0.005 0.0033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0101 0.0198
Brugia malayi hypothetical protein 0.0037 0.0494 0.0751
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0101 0.0198
Plasmodium vivax glutathione reductase, putative 0.0053 0.082 0.2512
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.1778 0.1764
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0101 0.0084
Loa Loa (eye worm) hypothetical protein 0.033 0.6579 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0809 0.1229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7311 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.2091 0.3161
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0809 0.1229
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.2908 0.2896
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0016 0.005 0.0033
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.3145 1
Loa Loa (eye worm) glutathione reductase 0.0053 0.082 0.1224
Onchocerca volvulus 0.0016 0.005 0.0045
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.082 0.2512
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.2091 0.3178
Echinococcus multilocularis muscleblind protein 0.033 0.6579 0.6573
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0101 0.0085
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0023 0.0191 0.0998
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.182 0.1806
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0016 0.005 0.0076
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.082 0.0804
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.047 0.0454
Echinococcus granulosus low density lipoprotein receptor ldl 0.0016 0.005 0.0033
Trypanosoma brucei trypanothione reductase 0.0053 0.082 0.1073
Echinococcus multilocularis tumor protein p63 0.0378 0.7579 0.7575
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0809 0.209
Mycobacterium ulcerans aminopeptidase N PepN 0.0037 0.0494 0.1235
Brugia malayi AMP-binding enzyme family protein 0.0015 0.004 0.006
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Schistosoma mansoni chromobox protein 0.0075 0.1283 0.1268
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.195 0.1937
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0583 0.0567
Onchocerca volvulus 0.0126 0.2349 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.195 0.2947
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0596 0.2409
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0023 0.0191 0.0615
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0016 0.005 0.0033
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0101 0.0084
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0579 0.1467
Schistosoma mansoni hypothetical protein 0.0024 0.0211 0.0194
Loa Loa (eye worm) hypothetical protein 0.0036 0.047 0.0691
Schistosoma mansoni hypothetical protein 0.0078 0.1341 0.1326
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0023 0.0191 0.1888
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0037 0.0494 0.0478
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0139 0.0321
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0662 0.2697
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0583 0.1749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.182 0.1806
Schistosoma mansoni cpg binding protein 0.0037 0.0483 0.0467
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0583 0.0567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.182 0.1806
Loa Loa (eye worm) hypothetical protein 0.0099 0.1778 0.2684
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0579 0.0563
Loa Loa (eye worm) FKBP5 protein 0.0165 0.3145 0.4767
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0023 0.0191 0.0998
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.2229 0.5951
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1088 0.6891
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.182 0.1806
Loa Loa (eye worm) hypothetical protein 0.0052 0.0809 0.1206
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.1778 0.1764
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Brugia malayi chromobox protein homolog 3 0.0042 0.0596 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0191 0.0489
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0787
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.047 0.0691
Echinococcus granulosus aminopeptidase N 0.0126 0.2349 0.2336
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0016 0.005 0.005
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0023 0.0191 0.0296
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1985 0.1971
Echinococcus multilocularis protein patched 0.0046 0.0677 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0191 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.182 0.1806
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0787
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0101 0.0084
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0023 0.0191 0.0266
Onchocerca volvulus 0.0016 0.005 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0064 0.0077
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.1778 0.1764
Mycobacterium ulcerans hypothetical protein 0.0192 0.3718 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1251 0.1236
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0677 0.0661
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0165 0.3145 0.3133
Echinococcus granulosus tar DNA binding protein 0.0069 0.1155 0.114
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.082 0.1224
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0489 0.1222
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0579 0.0742
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.7311 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0023 0.0191 0.0998
Loa Loa (eye worm) hypothetical protein 0.0046 0.0677 0.1006
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0809 0.209
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0114 0.2091 0.3161
Loa Loa (eye worm) peptidase family M1 containing protein 0.0102 0.1847 0.2789
Brugia malayi Latrophilin receptor protein 2 0.0036 0.047 0.0715
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.087 0.0855
Schistosoma mansoni hypothetical protein 0.0044 0.0643 0.0627
Schistosoma mansoni inositol monophosphatase 0.0041 0.0579 0.0563
Plasmodium falciparum methionine aminopeptidase 2 0.0088 0.156 0.4897
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0165 0.3145 0.3133
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0677 0.2053
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Schistosoma mansoni cpg binding protein 0.0035 0.0442 0.0426
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.3145 0.4271
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1283 0.4002
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0101 0.0085
Trichomonas vaginalis chromobox protein, putative 0.0075 0.1283 0.4002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Loa Loa (eye worm) hypothetical protein 0.003 0.0341 0.0494
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0023 0.0191 0.0296
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0583 0.1749
Echinococcus multilocularis GPCR, family 2 0.0036 0.047 0.0454
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0494 0.0625
Schistosoma mansoni amidase 0.0099 0.1778 0.1764
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0583 0.1749
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0494 0.1463
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0088 0.156 0.4897
Echinococcus granulosus histone deacetylase 1 0.0041 0.0583 0.0567
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0165 0.3145 0.8442
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0583 0.0862
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0088 0.156 0.4897
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0579 0.0742
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.004 0.0035
Trypanosoma cruzi Aminopeptidase M1, putative 0.0037 0.0494 0.0625
Onchocerca volvulus 0.0055 0.087 0.3598
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0809 0.3114
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0809 0.1058
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0165 0.3145 0.4767
Loa Loa (eye worm) hypothetical protein 0.0033 0.0407 0.0594
Brugia malayi Thioredoxin reductase 0.0053 0.082 0.1246
Brugia malayi enteropeptidase precursor 0.0016 0.005 0.0076
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0579 1
Brugia malayi RNA binding protein 0.0069 0.1155 0.1756
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0341 0.0325
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Schistosoma mansoni hypothetical protein 0.0044 0.0643 0.0627
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.2674 0.2661
Schistosoma mansoni immunophilin 0.0165 0.3145 0.3133
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0809 0.2476
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0101 0.0404
Leishmania major methionine aminopeptidase 2, putative 0.0088 0.156 0.2091
Brugia malayi hypothetical protein 0.003 0.0341 0.0519
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0222 0.0205
Schistosoma mansoni immunophilin 0.0142 0.2674 0.2661
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0494 0.0625
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0787
Brugia malayi AMP-binding enzyme family protein 0.0015 0.004 0.006
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0533 0.159
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.2509 0.6712
Trypanosoma brucei histone deacetylase 1 0.0041 0.0583 0.0747
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Schistosoma mansoni chromobox protein 0.0075 0.1283 0.1268
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.7311 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.3145 0.4271
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.082 0.0804
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0809 0.209
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0489 0.1221
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0489
Schistosoma mansoni hypothetical protein 0.0044 0.0643 0.0627
Loa Loa (eye worm) hypothetical protein 0.0052 0.0809 0.1206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0489 0.1221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0139 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1155 0.114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.182 0.1806
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.7311 1
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0341 0.1306
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.004 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1021 0.1349
Loa Loa (eye worm) hypothetical protein 0.0056 0.0893 0.1334
Echinococcus granulosus GPCR family 2 0.0036 0.047 0.0454
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Schistosoma mansoni cpg binding protein 0.0037 0.0483 0.0467
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0583 0.0886
Brugia malayi Inositol-1 0.0041 0.0579 0.088
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.3145 0.4271
Brugia malayi amidase 0.0099 0.1778 0.2703
Loa Loa (eye worm) hypothetical protein 0.0113 0.2077 0.3139
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0165 0.3145 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0583 0.1749
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0222 0.0251
Giardia lamblia Histone deacetylase 0.0041 0.0583 0.1582
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0583 0.1749
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.004 0.0023
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0016 0.005 0.0033
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.2509 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0101 0.0167
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0139 0.0321
Schistosoma mansoni histone deacetylase 0.0041 0.0583 0.0567
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0101 0.0085
Loa Loa (eye worm) hypothetical protein 0.0024 0.0222 0.0312
Giardia lamblia Hypothetical protein 0.0023 0.0191 0.0296
Loa Loa (eye worm) TAR-binding protein 0.0069 0.1155 0.1735
Echinococcus granulosus cpg binding protein 0.0037 0.0483 0.0467
Schistosoma mansoni fatty-acid amide hydrolase 0.0099 0.1778 0.1764
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0579 0.1737
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0494 0.0625
Trichomonas vaginalis fk506-binding protein, putative 0.0023 0.0191 0.0489
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0809 0.2476
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0016 0.005 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1155 0.114
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0677 0.0661
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.2509 0.6712
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0596 0.1791
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0016 0.005 0.0033
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0023 0.0191 0.0175
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.0076
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.3145 0.4271
Schistosoma mansoni hypothetical protein 0.0036 0.047 0.0454
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0101 0.0198
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Brugia malayi initiation factor 2-associated protein. 0.0088 0.156 0.2372
Brugia malayi Muscleblind-like protein 0.033 0.6579 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0139 0.0321
Echinococcus granulosus chromobox protein 1 0.0075 0.1283 0.1268
Toxoplasma gondii hypothetical protein 0.0059 0.0944 0.5949
Brugia malayi Histone deacetylase 1 0.0041 0.0583 0.0886
Leishmania major histone deacetylase, putative 0.0041 0.0583 0.0747
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.047 0.0454
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0677 0.1006
Brugia malayi CXXC zinc finger family protein 0.0035 0.0442 0.0672
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0583 0.0862
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0165 0.3145 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.004 0.006
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0494 0.0625
Echinococcus multilocularis aminopeptidase N 0.0126 0.2349 0.2336
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0583 0.3572
Plasmodium falciparum glutathione reductase 0.0018 0.0101 0.0198
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0101 0.0198
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.082 0.1073
Brugia malayi CUB domain containing protein 0.0016 0.005 0.0076
Loa Loa (eye worm) aminopeptidase N 0.0037 0.0494 0.0727
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0494 0.0625
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0052 0.0038
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0101 0.0198
Onchocerca volvulus 0.0052 0.0809 0.333
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0579 0.0563
Onchocerca volvulus 0.0023 0.0191 0.0657
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3312 0.4501
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0088 0.156 0.4897
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.1283 0.1929
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0101 0.0085
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0662 0.2005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0533 0.1342
Brugia malayi CHD4 protein 0.0014 0.0017 0.0026
Echinococcus granulosus low density lipoprotein receptor protein 0.0016 0.005 0.0033
Echinococcus granulosus chromobox protein 1 0.0075 0.1283 0.1268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0023 0.0191 0.0209
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0016 0.005 0.0045
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0023 0.0191 0.0209
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0809 0.1058
Leishmania major fk506-binding protein 1-like protein 0.0165 0.3145 0.4271
Echinococcus multilocularis tar DNA binding protein 0.0069 0.1155 0.114
Schistosoma mansoni inositol monophosphatase 0.0041 0.0579 0.0563
Echinococcus granulosus expressed conserved protein 0.0101 0.1815 0.1801
Plasmodium vivax methionine aminopeptidase 2, putative 0.0088 0.156 0.4897
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0037 0.0494 0.0478
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0494 0.0478
Onchocerca volvulus 0.0037 0.0494 0.1967
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0023 0.0191 0.0175
Entamoeba histolytica aminopeptidase, putative 0.0037 0.0494 0.1463
Loa Loa (eye worm) hypothetical protein 0.0042 0.0596 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1155 0.114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0787 0.1028
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0583 0.1749
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0139 0.0321
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Echinococcus multilocularis protein dispatched 1 0.0052 0.0812 0.0797
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0165 0.3145 0.4781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0101 0.0085
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0101 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0809 0.209
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.2229 0.5951
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0023 0.0191 0.0412
Brugia malayi Heterochromatin protein 1 0.0075 0.1283 0.195
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0809 0.2476
Plasmodium falciparum glutathione reductase 0.0053 0.082 0.2512
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0809 0.209
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0533 0.1342
Onchocerca volvulus 0.0033 0.0407 0.1589
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0165 0.3145 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0494 0.0478
Echinococcus multilocularis chromobox protein 1 0.0075 0.1283 0.1268
Echinococcus multilocularis methionyl aminopeptidase 2 0.0088 0.156 0.1546
Schistosoma mansoni immunophilin 0.0165 0.3145 0.3133
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0165 0.3145 0.4781
Loa Loa (eye worm) hypothetical protein 0.0078 0.1341 0.2018
Echinococcus granulosus methionyl aminopeptidase 2 0.0088 0.156 0.1546
Loa Loa (eye worm) hypothetical protein 0.0041 0.0583 0.0862
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.195 0.1937
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.047 0.0715
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0787
Loa Loa (eye worm) hypothetical protein 0.003 0.0341 0.0494
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0016 0.005 0.0033
Schistosoma mansoni fk506 binding protein 0.0023 0.0191 0.0175
Echinococcus multilocularis fk506 binding protein 0.0165 0.3145 0.3133
Loa Loa (eye worm) hypothetical protein 0.0039 0.0533 0.0787
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0064 0.0077
Trichomonas vaginalis fk506-binding protein, putative 0.0165 0.3145 1
Echinococcus granulosus tumor protein p63 0.0378 0.7579 0.7575
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0035
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0023 0.0191 0.1888
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0139 0.0321
Schistosoma mansoni hypothetical protein 0.0036 0.047 0.0454
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.1778 0.1764
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0101 0.0404
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0583 0.3572
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1155 0.114
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0583 0.0886
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0165 0.3145 1
Echinococcus multilocularis 0.0023 0.0191 0.0175
Leishmania major peptidylprolyl isomerase-like protein 0.0165 0.3145 0.4271
Toxoplasma gondii thioredoxin reductase 0.0053 0.082 0.5131
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0016 0.005 0.0045
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0579 0.3548
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0101 0.0167
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.005 0.0076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.082 0.2121
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0809 0.209
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1155 0.114
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.005 0.005
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0023 0.0191 0.0209
Plasmodium falciparum thioredoxin reductase 0.0053 0.082 0.2512
Brugia malayi AMP-binding enzyme family protein 0.0015 0.004 0.006
Brugia malayi basement membrane proteoglycan precursor 0.0016 0.005 0.0076
Loa Loa (eye worm) RNA binding protein 0.0069 0.1155 0.1735
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0579 0.1737
Mycobacterium ulcerans hypothetical protein 0.0023 0.0191 0.0412
Mycobacterium ulcerans hypothetical protein 0.0052 0.0809 0.209
Schistosoma mansoni hypothetical protein 0.0036 0.047 0.0454
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.005
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.2674 0.2661
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0016 0.005 0.005
Onchocerca volvulus 0.0016 0.005 0.0045
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.3145 0.4271
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0016 0.005 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0015 0.004 0.006
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0023 0.0191 0.0296
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.2509 0.6712
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0139 0.0321
Echinococcus multilocularis muscleblind protein 1 0.033 0.6579 0.6573
Plasmodium falciparum histone deacetylase 1 0.0041 0.0583 0.1749
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0191 0.0209
Echinococcus granulosus basement membrane specific heparan sulfate 0.0016 0.005 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.2908 0.2896
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0024 0.0222 0.0205
Onchocerca volvulus 0.003 0.0341 0.1306
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0016 0.005 0.0033
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0016 0.005 0.0033
Brugia malayi glutathione reductase 0.0053 0.082 0.1246
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0583 0.0747
Echinococcus granulosus caspase 2 0.003 0.0341 0.0325

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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