Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0005 | 0.0053 | 0.0199 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.2667 | 0.6023 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4678 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.2667 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.4088 | 0.4057 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0005 | 0.0053 | 0.0199 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2667 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0005 | 0.0053 | 0.0199 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.2667 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.2667 | 0.5651 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0634 | 0.1257 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.2667 | 1 |
Onchocerca volvulus | 0.0035 | 0.4393 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1658 | 0.3699 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0005 | 0.0053 | 0.0199 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0634 | 0.1257 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.2667 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2667 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.4088 | 0.8724 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0005 | 0.0053 | 0.0199 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8867 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.2667 | 0.2966 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.1916 |
Onchocerca volvulus | 0.0033 | 0.4088 | 0.9297 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1572 | 0.3501 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1908 | 0.4273 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.2667 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.2667 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.465 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0939 | 0.1916 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.4088 | 0.4057 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1572 | 0.3501 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1658 | 0.3471 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4393 | 0.4363 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0005 | 0.0053 | 0.0199 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.1908 | 0.4273 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0005 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0939 | 0.2042 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.4088 | 0.9297 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.4088 | 0.9297 |
Echinococcus granulosus | lamin | 0.0033 | 0.4088 | 0.8724 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.2667 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4393 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Echinococcus multilocularis | musashi | 0.0033 | 0.4088 | 0.8724 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.4088 | 0.9297 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.2667 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0005 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2667 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.4088 | 0.8724 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0005 | 0.0053 | 0.0199 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0634 | 0.0584 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1658 | 0.3471 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0634 | 0.1257 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.2667 | 0.5651 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2667 | 0.2628 |
Schistosoma mansoni | lamin | 0.0033 | 0.4088 | 0.4057 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.2667 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.2667 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4678 | 0.465 |
Onchocerca volvulus | 0.0033 | 0.4088 | 0.9297 | |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.2667 | 0.6023 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.4088 | 0.8724 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.4002 | 0.9099 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.092 | 0.1996 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 0.1969 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0634 | 0.1257 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.2667 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4678 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4393 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 0.1969 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 0.1969 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.2667 | 0.2628 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0109 | 0.0056 |
Echinococcus multilocularis | lamin | 0.0033 | 0.4088 | 0.8724 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.4088 | 0.9297 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.4088 | 0.9297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.