Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | peroxidasin | 0.0038 | 0.1088 | 0.1277 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0062 | 0.2504 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0062 | 0.2504 | 0.2939 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0028 | 0.046 | 1 |
Schistosoma mansoni | peroxidasin | 0.0038 | 0.1088 | 0.1277 |
Toxoplasma gondii | pyruvate carboxylase | 0.0062 | 0.2504 | 0.2839 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0022 | 0.012 | 0.014 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0022 | 0.012 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0062 | 0.2504 | 0.2939 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.1236 | 0.1451 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0028 | 0.046 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0062 | 0.2504 | 1 |
Leishmania major | carboxylase, putative | 0.0062 | 0.2504 | 0.2939 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0022 | 0.012 | 0.014 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0022 | 0.012 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Schistosoma mansoni | pyruvate carboxylase | 0.0062 | 0.2504 | 0.2939 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0163 | 0.8519 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0163 | 0.8519 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0163 | 0.8519 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0163 | 0.8519 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0163 | 0.8519 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0062 | 0.2504 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0022 | 0.012 | 0.014 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0022 | 0.012 | 0.0478 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0022 | 0.012 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0157 | 0.8179 | 0.8179 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0038 | 0.1088 | 0.1088 |
Brugia malayi | Peroxidasin | 0.0038 | 0.1088 | 0.1088 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0062 | 0.2504 | 0.2939 |
Brugia malayi | Animal haem peroxidase family protein | 0.0038 | 0.1088 | 0.1088 |
Brugia malayi | Animal haem peroxidase family protein | 0.0038 | 0.1088 | 0.1088 |
Brugia malayi | Blistered cuticle protein 3 | 0.0038 | 0.1088 | 0.1088 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0062 | 0.2504 | 0.2939 |
Chlamydia trachomatis | biotin carboxylase | 0.0056 | 0.2164 | 1 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0022 | 0.012 | 0.0478 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0022 | 0.012 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0022 | 0.012 | 0.0478 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0062 | 0.2504 | 0.2939 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0022 | 0.012 | 0.014 |
Schistosoma mansoni | peroxidasin | 0.0038 | 0.1088 | 0.1277 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0062 | 0.2504 | 0.2939 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0062 | 0.2504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Brugia malayi | Animal haem peroxidase family protein | 0.0038 | 0.1088 | 0.1088 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.0022 | 0.012 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0062 | 0.2504 | 0.5197 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0062 | 0.2504 | 0.2939 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0118 | 0.5834 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0062 | 0.2504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0163 | 0.8519 | 1 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0022 | 0.012 | 0.0478 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0038 | 0.1088 | 0.1088 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0187 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0038 | 0.1088 | 0.1277 |
Brugia malayi | Animal haem peroxidase family protein | 0.0038 | 0.1088 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0022 | 0.012 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1088 | 0.1088 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0062 | 0.2504 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0118 | 0.5834 | 0.5 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0062 | 0.2504 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0101 | 0.4818 | 1 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0022 | 0.012 | 0.014 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0157 | 0.8179 | 0.8179 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0163 | 0.8519 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0062 | 0.2504 | 0.5197 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.0022 | 0.012 | 0.0478 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0038 | 0.1088 | 0.1088 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0022 | 0.012 | 0.0478 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0062 | 0.2504 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0038 | 0.1088 | 0.1088 |
Brugia malayi | Animal haem peroxidase family protein | 0.0038 | 0.1088 | 0.1088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.