Detailed information for compound 895328

Basic information

Technical information
  • TDR Targets ID: 895328
  • Name: 4-(4-methylphenyl)sulfonyl-N-pentyl-2-propyls ulfonyl-1,3-thiazol-5-amine
  • MW: 430.605 | Formula: C18H26N2O4S3
  • H donors: 1 H acceptors: 5 LogP: 5.57 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCS(=O)(=O)c1sc(c(n1)S(=O)(=O)c1ccc(cc1)C)NCCCCC
  • InChi: 1S/C18H26N2O4S3/c1-4-6-7-12-19-16-17(20-18(25-16)26(21,22)13-5-2)27(23,24)15-10-8-14(3)9-11-15/h8-11,19H,4-7,12-13H2,1-3H3
  • InChiKey: MGVKRABRJVCAIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(4-methylphenyl)sulfonyl-N-pentyl-2-propylsulfonyl-thiazol-5-amine
  • 4-(4-methylphenyl)sulfonyl-N-pentyl-2-propylsulfonyl-5-thiazolamine
  • amyl-[4-(4-methylphenyl)sulfonyl-2-propylsulfonyl-thiazol-5-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0389 0.0452
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0389 0.0389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0205 0.0205
Toxoplasma gondii LsmAD domain-containing protein 0.0044 0.0573 0.0675
Leishmania major dihydroorotate dehydrogenase 0.0554 0.8235 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0104 0.1476 0.2661
Brugia malayi Inositol-1 0.0031 0.0389 0.0451
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0537 0.0631
Schistosoma mansoni lamin 0.0026 0.0313 0.0313
Echinococcus multilocularis microtubule associated protein 2 0.0672 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0845 0.0845
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0343 0.1032
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0205 0.0205
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0389 0.0451
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.013 0.0205
Echinococcus multilocularis neuropeptide receptor A26 0.0392 0.5796 0.5796
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0442 0.0516
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0554 0.8235 1
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0554 0.8235 1
Trypanosoma brucei PAB1-binding protein , putative 0.0044 0.0573 0.0675
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0216 0.3166 0.3166
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0845 0.0845
Echinococcus multilocularis lamin dm0 0.0026 0.0313 0.0313
Plasmodium falciparum ataxin-2 like protein, putative 0.0044 0.0573 0.0675
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0031 0.0389 0.0389
Schistosoma mansoni hypothetical protein 0.0019 0.0205 0.0205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0205 0.0228
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0554 0.8235 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0442 0.0516
Schistosoma mansoni hypothetical protein 0.0019 0.0205 0.0205
Echinococcus multilocularis lamin 0.0026 0.0313 0.0313
Schistosoma mansoni hypothetical protein 0.0205 0.299 0.299
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0244 0.0413
Echinococcus multilocularis snurportin 1 0.0372 0.5497 0.5497
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0216 0.3166 1
Echinococcus granulosus importin 5 0.0007 0.0018 0.0018
Schistosoma mansoni intermediate filament proteins 0.0026 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0104 0.1476 0.2661
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0343 0.1032
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0109 0.0109
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0019 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0205 0.0205
Schistosoma mansoni inositol monophosphatase 0.0031 0.0389 0.0389
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.002 0.002
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0442 0.0516
Echinococcus granulosus neuropeptide receptor A26 0.0392 0.5796 0.5796
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0153
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0389 0.0389
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0304 0.0348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0041 0.0535 0.0629
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0313 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0845 0.0845
Schistosoma mansoni microtubule-associated protein tau 0.0672 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0205 0.0341
Plasmodium vivax ataxin-2 like protein, putative 0.0044 0.0573 0.0675
Loa Loa (eye worm) hypothetical protein 0.0035 0.0442 0.0773
Schistosoma mansoni hypothetical protein 0.0372 0.5497 0.5497
Schistosoma mansoni ran 0.0026 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0044 0.0573 0.1012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0343 0.1032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0748 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0389 0.1179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0748 0.0748
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0031 0.0389 0.0389
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0748 0.0888
Echinococcus granulosus tar DNA binding protein 0.0062 0.0845 0.0845
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0313 0.0539
Schistosoma mansoni cpg binding protein 0.0023 0.0263 0.0263
Echinococcus granulosus neuropeptide s receptor 0.0392 0.5796 0.5796
Echinococcus multilocularis musashi 0.0026 0.0313 0.0313
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0031 0.0389 0.0389
Echinococcus multilocularis GPCR, family 2 0.0019 0.0205 0.0205
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0554 0.8235 1
Echinococcus multilocularis importin 5 0.0007 0.0018 0.0018
Schistosoma mansoni importin-beta 2 0.0007 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.002 0.0212 0.0212
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0109 0.0109
Brugia malayi RNA binding protein 0.0062 0.0845 0.1006
Schistosoma mansoni dihydroorotate dehydrogenase 0.0554 0.8235 0.8235
Brugia malayi Zinc finger, C2H2 type family protein 0.0216 0.3166 0.3831
Schistosoma mansoni hypothetical protein 0.0041 0.0537 0.0537
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0845 0.1006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0389 0.0108
Loa Loa (eye worm) RNA binding protein 0.0062 0.0845 0.1509
Loa Loa (eye worm) hypothetical protein 0.0113 0.161 0.2905
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0389 0.0107
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.002 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0026 0.0313 0.0539
Plasmodium falciparum dihydroorotate dehydrogenase 0.0554 0.8235 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0046 0.0609 0.0609
Brugia malayi hypothetical protein 0.0104 0.1476 0.1774
Echinococcus granulosus muscleblind protein 0.0113 0.161 0.161
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0389 0.1177
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0389 0.1177
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0554 0.8235 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0313 0.0359
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0389 0.0108
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0304 0.0348
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.013 0.0137
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0041 0.0537 0.0947
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0216 0.3166 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0304 0.0348
Echinococcus granulosus GPCR family 2 0.0019 0.0205 0.0205
Onchocerca volvulus 0.0026 0.0313 0.056
Echinococcus granulosus cpg binding protein 0.0023 0.0263 0.0263
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0216 0.3166 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0845 0.0845
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0031 0.0389 0.0389
Echinococcus granulosus lamin dm0 0.0026 0.0313 0.0313
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0748 0.1332
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0304 0.0348
Leishmania major hypothetical protein, conserved 0.0044 0.0573 0.0675
Echinococcus multilocularis transportin 1 0.0007 0.0018 0.0018
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0554 0.8235 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0153
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0389 0.0451
Echinococcus granulosus translational activator gcn1 0.0007 0.0018 0.0018
Echinococcus multilocularis cpg binding protein 0.0023 0.0263 0.0263
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0389 0.0107
Echinococcus granulosus intermediate filament protein 0.0026 0.0313 0.0313
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0216 0.3166 0.3166
Echinococcus multilocularis geminin 0.0205 0.299 0.299
Loa Loa (eye worm) hypothetical protein 0.0013 0.0109 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0044 0.0573 0.0339
Echinococcus multilocularis translational activator gcn1 0.0007 0.0018 0.0018
Echinococcus granulosus transportin 1 0.0007 0.0018 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0044 0.0573 0.0675
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0031 0.0389 0.0452
Loa Loa (eye worm) hypothetical protein 0.0031 0.0389 0.0677
Echinococcus granulosus geminin 0.0205 0.299 0.299
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0031 0.0389 0.0452
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0031 0.0389 0.1179
Schistosoma mansoni hypothetical protein 0.0019 0.0205 0.0205
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0031 0.0389 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0554 0.8235 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0216 0.3166 1
Schistosoma mansoni ran 0.0026 0.0304 0.0304
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0343 0.0049
Schistosoma mansoni importin beta-1 0.0035 0.0442 0.0442
Echinococcus multilocularis neuropeptide s receptor 0.0392 0.5796 0.5796
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0748 0.0748
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0389 0.0389
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0304 0.0304
Trichomonas vaginalis ran, putative 0.0026 0.0304 0.0908
Onchocerca volvulus Huntingtin homolog 0.0104 0.1476 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0748 0.0748
Echinococcus granulosus dnaJ subfamily B 0.0308 0.4548 0.4548
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0845 0.1509
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0442 0.0442
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0216 0.3166 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0389 0.1179
Loa Loa (eye worm) histone methyltransferase 0.0007 0.002 0.0003
Loa Loa (eye worm) hypothetical protein 0.006 0.0823 0.1468
Echinococcus granulosus lamin 0.0026 0.0313 0.0313
Echinococcus multilocularis dnaJ subfamily B 0.0308 0.4548 0.4548
Loa Loa (eye worm) hypothetical protein 0.0113 0.161 0.2905
Brugia malayi hypothetical protein 0.0044 0.0573 0.0675
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0554 0.8235 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0389 0.0451
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0216 0.3166 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0216 0.3166 0.3166
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0823 0.1468
Schistosoma mansoni cpg binding protein 0.0022 0.0244 0.0244
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0823 0.0979
Schistosoma mansoni lamin 0.0026 0.0313 0.0313
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0216 0.3166 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5497 1
Loa Loa (eye worm) inositol-1 0.0031 0.0389 0.0676
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0554 0.8235 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0823 0.0979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0748 0.0748
Leishmania major GTP-binding protein, putative 0.0026 0.0304 0.0348
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.002 0.0212 0.0212
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0554 0.8235 1
Schistosoma mansoni cpg binding protein 0.0023 0.0263 0.0263
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0304 0.0521
Loa Loa (eye worm) hypothetical protein 0.0019 0.0205 0.0341
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0304 0.0348
Brugia malayi Muscleblind-like protein 0.0113 0.161 0.1937
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0205 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0525
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0845 0.1509
Schistosoma mansoni hypothetical protein 0.0205 0.299 0.299
Echinococcus granulosus ubiquitin specific protease 41 0.0031 0.0389 0.0389
Plasmodium vivax importin-beta 2, putative 0.0035 0.0442 0.0516
Entamoeba histolytica Ran family GTPase 0.0026 0.0304 0.0908
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0216 0.3166 0.3166
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0554 0.8235 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0343 0.0395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0205 0.0205
Entamoeba histolytica hypothetical protein 0.0028 0.0343 0.1032
Brugia malayi TAR-binding protein 0.0062 0.0845 0.1006
Brugia malayi RNA, U transporter 1 0.0099 0.1405 0.1688
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0442 0.0516
Brugia malayi CXXC zinc finger family protein 0.0022 0.0244 0.0275
Echinococcus granulosus snurportin 1 0.0372 0.5497 0.5497
Brugia malayi intermediate filament protein 0.0026 0.0313 0.0359
Onchocerca volvulus Huntingtin homolog 0.0104 0.1476 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0442 0.0442
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0845 0.0845
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0389 0.1177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0748 0.0748
Echinococcus multilocularis muscleblind protein 0.0113 0.161 0.161
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0216 0.3166 0.3609
Echinococcus multilocularis ubiquitin specific protease 41 0.0031 0.0389 0.0389
Trypanosoma cruzi PAB1-binding protein , putative 0.0044 0.0573 0.0339
Schistosoma mansoni hypothetical protein 0.0308 0.4548 0.4548
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0389 0.1177
Plasmodium falciparum importin beta, putative 0.0035 0.0442 0.0516
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0845 0.0845
Onchocerca volvulus 0.0026 0.0313 0.056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0748 0.0748
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0554 0.8235 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0031 0.0389 0.1179
Echinococcus multilocularis muscleblind protein 1 0.0113 0.161 0.161
Brugia malayi hypothetical protein 0.0028 0.0341 0.0393
Schistosoma mansoni hypothetical protein 0.0019 0.0205 0.0205
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.002 0.002
Schistosoma mansoni inositol monophosphatase 0.0031 0.0389 0.0389

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.