Detailed information for compound 895512

Basic information

Technical information
  • TDR Targets ID: 895512
  • Name: 2-methylsulfonyl-N-(12-oxo-7,8,9,10-tetrahydr o-6H-azepino[2,1-b]quinazolin-2-yl)acetamide
  • MW: 349.405 | Formula: C16H19N3O4S
  • H donors: 1 H acceptors: 4 LogP: 0.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CS(=O)(=O)C)Nc1ccc2c(c1)c(=O)n1c(n2)CCCCC1
  • InChi: 1S/C16H19N3O4S/c1-24(22,23)10-15(20)17-11-6-7-13-12(9-11)16(21)19-8-4-2-3-5-14(19)18-13/h6-7,9H,2-5,8,10H2,1H3,(H,17,20)
  • InChiKey: JACDQAPWOLHFJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(12-keto-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)-2-mesyl-acetamide
  • 2-methylsulfonyl-N-(12-oxo-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-2-yl)ethanamide
  • ChemDiv2_007412
  • 2-(methylsulfonyl)-N-(12-oxo-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-2-yl)acetamide
  • MLS000660505
  • SMR000310024
  • IDI1_006127

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0104 0.0996 0.3385
Echinococcus granulosus chromobox protein 1 0.0117 0.114 0.1474
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0177 0.0653
Echinococcus multilocularis peptidase Clp (S14 family) 0.004 0.0231 0.0231
Toxoplasma gondii hypothetical protein 0.0044 0.0281 0.1688
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0505 0.2019
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.004 0.0231 0.0948
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0063 0.0505 0.2019
Mycobacterium ulcerans hypothetical protein 0.0143 0.1455 0.5356
Schistosoma mansoni cytochrome-c oxidase 0.0104 0.0996 0.1288
Leishmania major cytochrome p450-like protein 0.0035 0.0177 0.0596
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0872 0.1127
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0077 0.0316
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0181 0.0724
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0077 0.0283
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0464 0.0464
Brugia malayi cytochrome c oxidase subunit II 0.0042 0.0256 0.0942
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0161 0.1663 0.4326
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0748 0.307
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0067 0.0558 0.7784
Schistosoma mansoni alpha-glucosidase 0.0138 0.1392 0.18
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0161 0.1663 0.6825
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0177 0.0596
Echinococcus multilocularis chromobox protein 1 0.0117 0.114 0.114
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1656 0.1656
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0333 0.043
Giardia lamblia Seryl-tRNA synthetase 0.0027 0.008 0.112
Schistosoma mansoni cytochrome P450 0.0027 0.0077 0.0099
Schistosoma mansoni histidyl-tRNA synthetase 0.004 0.024 0.0311
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0067 0.0558 0.2055
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0077 0.0283
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0181 0.0743
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0464 0.06
Schistosoma mansoni peroxidasin 0.0239 0.2589 0.3348
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0309 0.1238
Brugia malayi Cytochrome P450 family protein 0.0114 0.1115 0.4106
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0009 0.0033
Trichomonas vaginalis esterase, putative 0.0035 0.0181 0.0724
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0183 0.0731
Mycobacterium ulcerans seryl-tRNA synthetase 0.0027 0.008 0.0296
Loa Loa (eye worm) CHromoDomain protein family member 0.0021 0.0012 0.0045
Brugia malayi CHD4 protein 0.0021 0.0012 0.0045
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0077 0.0283
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0077 0.0283
Trypanosoma cruzi seryl-tRNA synthetase 0.0027 0.008 0.027
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0177 0.0596
Plasmodium vivax threonine--tRNA ligase, putative 0.0067 0.0558 0.2139
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2499 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0618 0.2276
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0181 0.0724
Treponema pallidum prolyl-tRNA synthetase 0.025 0.2716 1
Plasmodium falciparum proline--tRNA ligase, putative 0.0209 0.2238 1
Onchocerca volvulus 0.0051 0.0368 0.0776
Loa Loa (eye worm) hypothetical protein 0.006 0.0477 0.1756
Onchocerca volvulus 0.0104 0.0996 0.3385
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0077 0.0316
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0118 0.1156 0.4258
Onchocerca volvulus 0.0239 0.2588 0.9996
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0464 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0107 0.0139
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0858 0.5134
Brugia malayi cytochrome P450 0.0027 0.0077 0.0283
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0077 0.0316
Loa Loa (eye worm) hypothetical protein 0.0051 0.0368 0.1355
Echinococcus granulosus glycyl tRNA synthetase 0.0089 0.0814 0.1052
Plasmodium falciparum glycine--tRNA ligase 0.004 0.024 0.1074
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0505 0.2019
Loa Loa (eye worm) beta-lactamase 0.0035 0.0181 0.0667
Mycobacterium ulcerans lipase LipD 0.0035 0.0181 0.0667
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0077 0.0283
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0081 0.0717 0.4283
Leishmania major mitochondrial DNA polymerase beta 0.0272 0.2975 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0338 0.1246
Brugia malayi glycyl-tRNA synthetase 0.0089 0.0814 0.2996
Brugia malayi Heterochromatin protein 1 0.0117 0.114 0.4198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0872 0.321
Schistosoma mansoni chromobox protein 0.0117 0.114 0.1474
Toxoplasma gondii serine--tRNA ligase 0.0027 0.008 0.0483
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0156 0.0575
Schistosoma mansoni dihydroorotate dehydrogenase 0.0161 0.1663 0.215
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0177 0.0653
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0095 0.0122
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0077 0.0283
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.004 0.0231 0.0948
Brugia malayi beta-lactamase family protein 0.0035 0.0181 0.0667
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0161 0.1663 0.5589
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.004 0.024 0.3353
Schistosoma mansoni hypothetical protein 0.0205 0.2182 0.2821
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.1505
Loa Loa (eye worm) blistered cuticle protein 3 0.0239 0.2588 0.9531
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0309 0.1238
Echinococcus multilocularis seryl tRNA synthetase, mitochondrial 0.0027 0.008 0.008
Schistosoma mansoni alpha-glucosidase 0.0138 0.1392 0.18
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0872 0.1127
Plasmodium falciparum threonine--tRNA ligase 0.0067 0.0558 0.2494
Trypanosoma brucei seryl-tRNA synthetase 0.0027 0.008 0.027
Trypanosoma brucei glucosidase, putative 0.0036 0.0183 0.0614
Echinococcus multilocularis tumor protein p63 0.0494 0.5609 0.5609
Echinococcus granulosus microtubule associated protein 2 0.0674 0.7735 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0084 0.0758 0.098
Brugia malayi Blistered cuticle protein 3 0.0239 0.2588 0.9531
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0066 0.0544 0.0544
Schistosoma mansoni cytochrome oxidase subunit 0.0118 0.1156 0.1495
Mycobacterium leprae Probable lipase LipE 0.0035 0.0181 0.1042
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0009 0.0039
Echinococcus granulosus geminin 0.0205 0.2182 0.2821
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0104 0.0996 0.4089
Plasmodium vivax serine--tRNA ligase, putative 0.0027 0.008 0.0308
Onchocerca volvulus Peroxidase homolog 0.0239 0.2588 0.9996
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0872 0.321
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0181 0.0234
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0021 0.0012 0.0016
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0183 0.1099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0195 0.0195
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.004 0.024 0.0626
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0104 0.0996 0.3818
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0748 0.307
Echinococcus granulosus Threonyl tRNA synthetase C 0.0067 0.0558 0.0722
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0077 0.0258
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0084 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0033 0.0156 0.0575
Schistosoma mansoni zinc finger protein 0.0021 0.001 0.0013
Onchocerca volvulus Peroxidasin homolog 0.0239 0.2588 0.9996
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.006 0.0477 0.2869
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0129 0.1283 0.4312
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.006 0.0477 0.0477
Schistosoma mansoni threonyl-tRNA synthetase 0.0027 0.008 0.0104
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.006 0.0477 0.1828
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0067 0.0558 0.1877
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0667
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0067 0.0558 0.2055
Loa Loa (eye worm) hypothetical protein 0.0046 0.0301 0.1108
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0081 0.0717 0.2641
Loa Loa (eye worm) cytochrome P450 0.0027 0.0077 0.0283
Onchocerca volvulus 0.0118 0.1156 0.405
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0181 0.0724
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0717 0.2411
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0748 0.307
Plasmodium vivax cytochrome c oxidase subunit I 0.0118 0.1156 0.4431
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0181 0.0743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0872 0.1127
Echinococcus granulosus cytochrome c oxidase subunit 1 0.0118 0.1156 0.1495
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0077 0.0258
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1142 0.4204
Plasmodium falciparum cytochrome c oxidase subunit 1 0.0118 0.1156 0.5167
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.004 0.024 0.0962
Brugia malayi Bromodomain containing protein 0.0041 0.0246 0.0906
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1656 0.2141
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0181 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0181 0.0234
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0077 0.0283
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0067 0.0558 0.2291
Leishmania major glycyl tRNA synthetase, putative 0.004 0.024 0.0808
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0241 0.261 1
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0104 0.0996 0.3385
Echinococcus multilocularis zinc finger protein 0.0021 0.001 0.001
Brugia malayi Cytochrome P450 family protein 0.0035 0.0177 0.0653
Entamoeba histolytica hypothetical protein 0.0038 0.0217 0.3023
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0183 0.0614
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0181 0.0694
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0181 0.0609
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0195 0.0799
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0066 0.0544 0.0544
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0181 0.0667
Toxoplasma gondii thioredoxin reductase 0.0037 0.0195 0.117
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0077 0.0283
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0066 0.0544 0.0704
Plasmodium vivax proline--tRNA ligase, putative 0.0209 0.2238 0.8576
Plasmodium falciparum thioredoxin reductase 0.0037 0.0195 0.0869
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0066 0.0544 0.2178
Plasmodium vivax glutathione reductase, putative 0.0037 0.0195 0.0746
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0081 0.0717 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0084 0.0758 0.098
Schistosoma mansoni glycyl-tRNA synthetase 0.0089 0.0814 0.1052
Schistosoma mansoni cellular tumor antigen P53 0.0072 0.0618 0.0799
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Echinococcus granulosus cytochrome c oxidase subunit II 0.0345 0.3843 0.4969
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0067 0.0558 0.3322
Loa Loa (eye worm) hypothetical protein 0.0049 0.0338 0.1246
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0183 0.0731
Chlamydia trachomatis proline--tRNA ligase 0.025 0.2716 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0077 0.0283
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0077 0.0412
Brugia malayi hypothetical protein 0.0026 0.0071 0.0261
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0104 0.0996 0.3668
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0161 0.1663 0.6122
Brugia malayi cytochrome c oxidase subunit I 0.0048 0.0334 0.1229
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0516 0.0667
Brugia malayi SET domain containing protein 0.002 0.0001 0.0003
Schistosoma mansoni chromobox protein 0.0117 0.114 0.1474
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0181 0.0609
Loa Loa (eye worm) heterochromatin protein 1 0.0117 0.114 0.4198
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0217 0.028
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0065 0.0535 0.1469
Chlamydia trachomatis histidine--tRNA ligase 0.004 0.024 0.0608
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0077 0.0316
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Giardia lamblia Threonyl-tRNA synthetase 0.0067 0.0558 0.7784
Plasmodium vivax SET domain protein, putative 0.0029 0.0107 0.0412
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0009 0.0032
Leishmania major hypothetical protein, conserved 0.0026 0.0071 0.0238
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0077 0.0283
Mycobacterium ulcerans beta-lactamase 0.0035 0.0181 0.0667
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0066 0.0544 0.2178
Loa Loa (eye worm) hypothetical protein 0.0081 0.0717 0.2641
Loa Loa (eye worm) hypothetical protein 0.0047 0.0323 0.1188
Mycobacterium tuberculosis Conserved hypothetical protein 0.0143 0.1455 0.5971
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0077 0.0283
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0077 0.0283
Trichomonas vaginalis chromobox protein, putative 0.007 0.0593 0.2374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0323 0.0417
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0077 0.0316
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0038 0.0214 0.072
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.1756
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0464 0.1709
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0032 0.0139 0.0512
Loa Loa (eye worm) hypothetical protein 0.0239 0.2589 0.9534
Brugia malayi beta-lactamase 0.0035 0.0181 0.0667
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0077 0.0316
Mycobacterium tuberculosis Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) 0.0118 0.1156 0.4747
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Brugia malayi Pre-SET motif family protein 0.0203 0.2167 0.7979
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0183 0.0731
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0214 0.072
Loa Loa (eye worm) hypothetical protein 0.0065 0.0535 0.1969
Brugia malayi Sars1 protein 0.0027 0.008 0.0296
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0104 0.0996 0.3385
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0161 0.1663 1
Schistosoma mansoni cytochrome oxidase subunit 0.0118 0.1156 0.1495
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.004 0.0231 0.1343
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0021 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.1241
Schistosoma mansoni prolyl-tRNA synthetase 0.0209 0.2238 0.2893
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0667
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0071 0.0238
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.7735 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0181 0.0609
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0161 0.1663 0.6122
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1656 0.6098
Mycobacterium tuberculosis Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) 0.0183 0.192 0.7882
Schistosoma mansoni alpha glucosidase 0.0036 0.0183 0.0236
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0464 0.1709
Mycobacterium ulcerans cytochrome C oxidase polypeptide I CtaD 0.0118 0.1156 0.4258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0872 0.0872
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.006 0.0477 0.0617
Plasmodium vivax glycine--tRNA ligase, putative 0.0067 0.0558 0.2139
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0183 0.0731
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0077 0.0283
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0067 0.0558 0.2055
Mycobacterium tuberculosis Conserved protein 0.0035 0.0181 0.0743
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0089 0.0814 0.2996
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0161 0.1663 0.5589
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2588 0.9531
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2588 0.9531
Schistosoma mansoni threonyl-tRNA synthetase 0.004 0.024 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0535 0.214
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0077 0.0316
Plasmodium falciparum histidine--tRNA ligase, putative 0.004 0.024 0.1074
Mycobacterium tuberculosis Conserved protein 0.0035 0.0181 0.0743
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0195 0.0252
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0077 0.0283
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0077 0.0316
Brugia malayi Zinc finger, C2H2 type family protein 0.0063 0.0505 0.1858
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0038 0.0214 0.072
Loa Loa (eye worm) cytochrome c oxidase subunit II 0.0042 0.0256 0.0942
Brugia malayi beta-lactamase family protein 0.0035 0.0181 0.0667
Schistosoma mansoni bromodomain containing protein 0.0068 0.0561 0.0726
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0107 0.0107
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0129 0.1283 0.4312
Brugia malayi Bromodomain containing protein 0.008 0.0709 0.2612
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0071 0.0317
Onchocerca volvulus Peroxidasin homolog 0.0239 0.2589 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Treponema pallidum seryl-tRNA synthetase 0.0027 0.008 0.0296
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0858 0.3522
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0161 0.1663 0.6122
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0535 0.214
Schistosoma mansoni peroxidasin 0.0239 0.2588 0.3346
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0047 0.0061
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0181 0.0743
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.006 0.0477 0.2831
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0181 0.0724
Loa Loa (eye worm) hypothetical protein 0.0041 0.0247 0.0909
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0104 0.0996 0.4451
Trypanosoma cruzi histidyl-tRNA synthetase 0.004 0.024 0.0808
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0667
Loa Loa (eye worm) cytochrome P450 family protein 0.0114 0.1115 0.4106
Plasmodium falciparum serine--tRNA ligase, putative 0.0027 0.008 0.0359
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0464 0.2791
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0077 0.0283
Brugia malayi Thioredoxin reductase 0.0037 0.0195 0.0716
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2588 0.9531
Mycobacterium ulcerans histidyl-tRNA synthetase 0.004 0.024 0.0885
Echinococcus granulosus peroxidasin 0.0239 0.2589 0.3348
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0181 0.0667
Brugia malayi chromobox protein homolog 3 0.0065 0.0535 0.1969
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0161 0.1663 0.6371
Onchocerca volvulus Peroxidase homolog 0.0239 0.2588 0.9996
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.025 0.2716 1
Echinococcus multilocularis histidyl tRNA synthetase 0.004 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.1505
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.004 0.024 0.0808
Echinococcus multilocularis chromobox protein 1 0.0117 0.114 0.114
Trypanosoma brucei histidyl-tRNA synthetase 0.004 0.024 0.0808
Echinococcus multilocularis glycyl tRNA synthetase 0.0089 0.0814 0.0814
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0748 0.307
Entamoeba histolytica hypothetical protein 0.0038 0.0217 0.3023
Entamoeba histolytica seryl-tRNA synthetase, putative 0.0027 0.008 0.112
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0181 0.0743
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0067 0.0558 0.2234
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0183 0.0614
Toxoplasma gondii hypothetical protein 0.0021 0.0009 0.0052
Schistosoma mansoni cytochrome oxidase subunit 0.0118 0.1156 0.1495
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2588 0.9531
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0183 0.0673
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0183 0.0731
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.1756
Leishmania major hypothetical protein, conserved 0.0035 0.0181 0.0609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0872 0.1127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0323 0.0417
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0195 0.0654
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0183 0.0236
Trichomonas vaginalis chromobox protein, putative 0.0117 0.114 0.4562
Trichomonas vaginalis chromobox protein, putative 0.0117 0.114 0.4562
Toxoplasma gondii anticodon binding domain-containing protein 0.004 0.024 0.1446
Brugia malayi Cytochrome P450 family protein 0.0035 0.0177 0.0653
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0872 0.1127
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0183 0.2548
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0067 0.0558 0.1452
Giardia lamblia Prolyl-tRNA synthetase 0.0081 0.0717 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0077 0.0283
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0081 0.0717 0.287
Mycobacterium leprae PROBABLE TRANSMEMBRANE CYTOCHROME C OXIDASE (SUBUNIT II) CTAC 0.0063 0.0503 0.2988
Plasmodium falciparum proline--tRNA ligase 0.0081 0.0717 0.3204
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0161 0.1663 0.5589
Mycobacterium ulcerans hypothetical protein 0.0035 0.0181 0.0667
Plasmodium vivax proline--tRNA ligase, putative 0.0081 0.0717 0.2748
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0067 0.0558 0.1877
Loa Loa (eye worm) hypothetical protein 0.0044 0.0277 0.1019
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0063 0.0505 0.1696
Plasmodium vivax serine--tRNA ligase, putative 0.0027 0.008 0.0308
Entamoeba histolytica seryl-tRNA synthetase, putative 0.0027 0.008 0.112
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0071 0.0317
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0338 0.1246
Onchocerca volvulus Cytochrome c oxidase subunit 1 homolog 0.0118 0.1156 0.405
Plasmodium vivax histidine--tRNA ligase, putative 0.004 0.024 0.0921
Trypanosoma brucei trypanothione reductase 0.0037 0.0195 0.0654
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.0027 0.008 0.0321
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0106 0.1013 0.3732
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0077 0.0283
Toxoplasma gondii ABC1 family protein 0.0035 0.0181 0.1089
Echinococcus multilocularis 0.0027 0.0077 0.0077
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0464 0.06
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0047 0.0047
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0181 0.0743
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0077 0.0316
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0464 0.1905
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.7735 0.7735
Brugia malayi Pre-SET motif family protein 0.0029 0.0107 0.0396
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0081 0.0717 0.2411
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0181 0.0724
Schistosoma mansoni cytochrome c oxidase subunit I 0.0048 0.0334 0.0431
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0181 0.0181
Onchocerca volvulus 0.0239 0.2588 0.9996
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0067 0.0558 0.1877
Schistosoma mansoni hypothetical protein 0.0022 0.0023 0.003
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0063 0.0503 0.1852
Onchocerca volvulus 0.0093 0.0858 0.281
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0214 0.072
Schistosoma mansoni hypothetical protein 0.0205 0.2182 0.2821
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0177 0.0596
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0071 0.0272
Toxoplasma gondii tRNA ligase class II core domain (G, H, P, S and T) domain-containing protein 0.0027 0.008 0.0483
Leishmania major trypanothione reductase 0.0037 0.0195 0.0654
Schistosoma mansoni peptidase Clp (S14 family) 0.006 0.0477 0.0617
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0077 0.0316
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0183 0.0183
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0183 0.0731
Echinococcus granulosus seryl tRNA synthetase mitochondrial 0.0027 0.008 0.0104
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0067 0.0558 0.3357
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0081 0.0717 0.2411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0667
Brugia malayi hypothetical protein 0.0239 0.2588 0.9531
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.004 0.024 0.0962
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0748 0.447
Onchocerca volvulus 0.0072 0.0618 0.1815
Echinococcus granulosus Seryl tRNA Synthetase 0.0027 0.008 0.0104
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0717 0.2411
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0129 0.1283 0.4312
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0323 0.0323
Schistosoma mansoni hypothetical protein 0.0027 0.0077 0.0099
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0047 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0077 0.0316
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0107 0.0646
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0067 0.0558 0.1877
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0081 0.0717 0.2411
Plasmodium falciparum glutathione reductase 0.0037 0.0195 0.0869
Entamoeba histolytica hypothetical protein 0.0038 0.0217 0.3023
Leishmania major cytochrome p450-like protein 0.0027 0.0077 0.0258
Wolbachia endosymbiont of Brugia malayi seryl-tRNA synthetase 0.0027 0.008 0.0209
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0077 0.0316
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0077 0.0283
Schistosoma mansoni cytochrome oxidase subunit 0.0118 0.1156 0.1495
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0195 0.0716
Loa Loa (eye worm) histidyl-tRNA synthetase 0.004 0.024 0.0885
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0667
Echinococcus granulosus histidyl tRNA synthetase 0.004 0.024 0.0311
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1656 0.6098
Loa Loa (eye worm) Sars1 protein 0.0027 0.008 0.0296
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0071 0.0238
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0067 0.0558 0.7784
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0272 0.2975 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0181 0.0743
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0183 0.2548
Toxoplasma gondii glycyl-tRNA synthetase 0.0067 0.0558 0.3357
Plasmodium falciparum serine--tRNA ligase, putative 0.0027 0.008 0.0359
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0313 0.1052
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1656 0.1656
Brugia malayi seryl-tRNA synthetase, mitochondrial precursor, putative 0.0027 0.008 0.0296
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0077 0.0316
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0077 0.0316
Giardia lamblia Glycyl-tRNA synthetase 0.0067 0.0558 0.7784
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0181 0.0743
Leishmania major threonyl-tRNA synthetase, putative 0.0067 0.0558 0.1877
Loa Loa (eye worm) hypothetical protein 0.025 0.2716 1
Echinococcus granulosus peptidase Clp S14 family 0.004 0.0231 0.0298
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0464 0.1709
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2588 0.9531
Echinococcus multilocularis geminin 0.0205 0.2182 0.2182
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0104 0.0996 0.3385
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0505 0.2019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0216 0.0216
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.006 0.0477 0.2869
Chlamydia trachomatis threonine--tRNA ligase 0.0067 0.0558 0.1813
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0077 0.0316
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.0209 0.2238 0.2238
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0066 0.0544 0.7589
Mycobacterium leprae putative cytochrome p450 0.0027 0.0077 0.0412
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.004 0.024 0.0808
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0183 0.0673
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0516 0.0516
Toxoplasma gondii seryl-tRNA synthetase, cytoplasmic, putative 0.0027 0.008 0.0483
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0067 0.0558 0.0558
Leishmania major dihydroorotate dehydrogenase 0.0161 0.1663 0.5589
Loa Loa (eye worm) cytochrome c oxidase subunit I 0.0048 0.0334 0.1229
Schistosoma mansoni histidyl-tRNA synthetase 0.004 0.024 0.0311
Leishmania major cytochrome p450-like protein 0.0027 0.0077 0.0258
Brugia malayi Peroxidasin 0.0239 0.2589 0.9534
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0081 0.0717 0.4313
Brugia malayi hypothetical protein 0.0038 0.0217 0.0798
Brugia malayi PHD-finger family protein 0.0027 0.0077 0.0284
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0066 0.0544 0.0704
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2588 0.9531
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0272 0.2975 1
Brugia malayi Met-10+ like-protein 0.0183 0.192 0.707
Loa Loa (eye worm) hypothetical protein 0.0081 0.0717 0.2641
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0338 0.1246
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.0209 0.2238 0.2893
Onchocerca volvulus Dual oxidase homolog 0.0239 0.2588 0.9996
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0181 0.0667
Echinococcus granulosus chromobox protein 1 0.0117 0.114 0.1474
Echinococcus granulosus zinc finger protein 0.0021 0.001 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0272 0.2975 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0077 0.0316
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0077 0.0283
Echinococcus multilocularis peroxidasin 0.0239 0.2589 0.2589
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0181 0.1042
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0077 0.0316
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 1 0.0118 0.1156 0.3009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0748 0.307
Schistosoma mansoni hypothetical protein 0.0038 0.0217 0.028
Onchocerca volvulus 0.0231 0.2499 0.9625
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0077 0.0099
Onchocerca volvulus Chorion peroxidase homolog 0.0239 0.2588 0.9996
Loa Loa (eye worm) glutathione reductase 0.0037 0.0195 0.0716
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0183 0.0731
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0858 0.3522
Plasmodium falciparum dihydroorotate dehydrogenase 0.0161 0.1663 0.7429
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0077 0.0258
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0464 0.156
Loa Loa (eye worm) hypothetical protein 0.0239 0.2588 0.9531
Onchocerca volvulus 0.0239 0.2588 0.9996
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0183 0.0731
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0183 0.0731
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0161 0.1663 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0077 0.0258
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.1756
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0027 0.008 0.0321
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0077 0.0316
Entamoeba histolytica hypothetical protein 0.0038 0.0217 0.3023
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0071 0.0238
Brugia malayi MH2 domain containing protein 0.0117 0.1142 0.4204
Onchocerca volvulus Heterochromatin protein 1 homolog 0.007 0.0593 0.1712
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0067 0.0558 0.2055
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0858 0.3522
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0345 0.3843 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0177 0.0653
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.006 0.0477 0.2131
Treponema pallidum threonyl-tRNA synthetase 0.0067 0.0558 0.2055
Trichomonas vaginalis chromobox protein, putative 0.007 0.0593 0.2374
Schistosoma mansoni seryl-tRNA synthetase 0.0027 0.008 0.0104
Mycobacterium tuberculosis Conserved protein 0.0035 0.0181 0.0743
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1142 0.4204
Mycobacterium ulcerans prolyl-tRNA synthetase 0.025 0.2716 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0655 0.2413
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) 0.0118 0.1156 0.6939
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0084 0.0758 0.098
Schistosoma mansoni hypothetical protein 0.0033 0.0156 0.0202
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0077 0.0316
Brugia malayi Probable ClpP-like protease 0.006 0.0477 0.1756
Schistosoma mansoni cytochrome c oxidase subunit II 0.0283 0.3103 0.4012
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0077 0.0283
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0071 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0183 0.0614
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0177 0.0653
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0104 0.0996 0.5992
Leishmania major histidyl-tRNA synthetase, putative 0.004 0.024 0.0808
Brugia malayi glutathione reductase 0.0037 0.0195 0.0716
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0181 0.0667
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0216 0.028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2167 0.7979
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0077 0.0283
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.004 0.024 0.1446
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.0027 0.008 0.0321
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0323 0.0417
Loa Loa (eye worm) hypothetical protein 0.0026 0.0071 0.0261
Mycobacterium tuberculosis Probable reductase 0.0083 0.0748 0.307
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0023 0.0085
Onchocerca volvulus 0.0048 0.0333 0.0631
Echinococcus granulosus tumor protein p63 0.0494 0.5609 0.7251
Schistosoma mansoni seryl-tRNA synthetase 0.0027 0.008 0.0104
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2588 0.9531
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0217 0.028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0872 0.0872
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0161 0.1663 0.5589
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.025 0.2716 0.7067
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0021 0.0012 0.0016
Loa Loa (eye worm) animal heme peroxidase 0.0239 0.2588 0.9531
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0077 0.0462
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0195 0.0746
Treponema pallidum glycyl-tRNA synthetase 0.004 0.024 0.0885
Loa Loa (eye worm) seryl-tRNA synthetase 0.0027 0.008 0.0296
Leishmania major seryl-tRNA synthetase, putative 0.0027 0.008 0.027
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0077 0.0258
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0217 0.0217
Brugia malayi Animal haem peroxidase family protein 0.0239 0.2588 0.9531
Echinococcus multilocularis Seryl tRNA Synthetase 0.0027 0.008 0.008
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0077 0.0316

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5174 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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