Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin I | 0.0503 | 0.0272 | 0.0144 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.5777 | 0.5912 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2256 | 0.2146 | 1 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0426 | 0.0189 | 0.0306 |
Plasmodium falciparum | plasmepsin II | 0.0503 | 0.0272 | 0.0144 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.5777 | 0.5912 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5777 | 0.5912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.0189 | 0.6968 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2256 | 0.2146 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0503 | 0.0272 | 0.0144 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0503 | 0.0272 | 0.0144 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.5777 | 0.5912 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2256 | 0.2146 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0503 | 0.0272 | 0.0144 |
Brugia malayi | Pepsin A precursor | 0.0426 | 0.0189 | 0.0306 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.07 | 0.0482 | 0.0298 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0426 | 0.0189 | 0.6968 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5777 | 0.5912 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2256 | 0.2146 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0503 | 0.0272 | 0.0144 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0503 | 0.0272 | 0.1231 |
Plasmodium vivax | plasmepsin IV, putative | 0.0503 | 0.0272 | 0.0144 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.5777 | 0.5912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.0272 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0503 | 0.0272 | 0.0144 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2256 | 0.2146 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2256 | 0.2146 | 0.3621 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2256 | 0.2146 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2256 | 0.2146 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0503 | 0.0272 | 0.1231 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0426 | 0.0189 | 0.6968 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.5777 | 0.5912 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0503 | 0.0272 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.5777 | 0.5912 | 0.5 |
Brugia malayi | hypothetical protein | 0.0426 | 0.0189 | 0.0306 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.5777 | 0.5912 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5777 | 0.5912 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.5777 | 0.5912 | 1 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0426 | 0.0189 | 0.0306 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.5777 | 0.5912 | 1 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0426 | 0.0189 | 0.0306 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.5777 | 0.5912 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0503 | 0.0272 | 0.0084 |
Brugia malayi | hypothetical protein | 0.0426 | 0.0189 | 0.0306 |
Onchocerca volvulus | 0.0426 | 0.0189 | 0.5 | |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2256 | 0.2146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.0189 | 0.6968 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2256 | 0.2146 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2256 | 0.2146 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.5777 | 0.5912 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.07 | 0.0482 | 0.0298 |
Onchocerca volvulus | 0.0426 | 0.0189 | 0.5 | |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.5777 | 0.5912 | 0.5833 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2256 | 0.2146 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.