Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydroorotate dehydrogenase | 0.1232 | 1 | 0.5 |
Toxoplasma gondii | 5'-nucleotidase, C-terminal domain-containing protein | 0.0139 | 0.0699 | 0.0696 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1232 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0274 | 0.1852 | 0.1262 |
Giardia lamblia | Hypothetical protein | 0.0057 | 0 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1232 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1232 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Schistosoma mansoni | 23-cyclic-nucleotide 2-phosphodiesterase | 0.0139 | 0.0699 | 0.0026 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1232 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1232 | 1 | 1 |
Treponema pallidum | 5'-nucleotidase (ushA) | 0.0139 | 0.0699 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0481 | 0.361 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0481 | 0.361 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.013 | 0.0625 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0481 | 0.361 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1232 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1232 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1232 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1232 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1232 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0274 | 0.1852 | 0.1262 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0481 | 0.361 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0481 | 0.361 | 0.3184 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1232 | 1 | 0.5 |
Schistosoma mansoni | 23-cyclic-nucleotide 2-phosphodiesterase | 0.0139 | 0.0696 | 0.0023 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1232 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1232 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0481 | 0.361 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.