Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0916 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0916 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0916 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.1441 | 0.1441 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0916 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0358 | 0.36 | 0.36 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1755 | 0.4876 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0916 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0916 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0916 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0916 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.1755 | 0.4876 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0358 | 0.36 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0916 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0358 | 0.36 | 1 |
Onchocerca volvulus | 0.0114 | 0.0804 | 0.5 | |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0916 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0916 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0358 | 0.36 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.1755 | 0.1755 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.1441 | 0.1441 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0358 | 0.36 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.1755 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0358 | 0.36 | 0.36 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0916 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0916 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.1755 | 0.4876 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0916 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0358 | 0.36 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.