TDR Targets

Basic information

Technical information

TDR Targets ID: 895855
Name: 4-methyl-N-[2-[(4-methylphenyl)amino]-2-pheny lethyl]benzenesulfonamide
MW: 380.503 | Formula: C22H24N2O2S
H donors: 2 H acceptors: 2 LogP: 4.83 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)NC(c1ccccc1)CNS(=O)(=O)c1ccc(cc1)C
InChi: 1S/C22H24N2O2S/c1-17-8-12-20(13-9-17)24-22(19-6-4-3-5-7-19)16-23-27(25,26)21-14-10-18(2)11-15-21/h3-15,22-24H,16H2,1-2H3
InChiKey: RBKCJJHKCCGTTA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-methyl-N-[2-[(4-methylphenyl)amino]-2-phenyl-ethyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin b	0.2589	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0654	0.2382	0.1619
Onchocerca volvulus		0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.1202	0.454	0.454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1202	0.454	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2589	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1202	0.454	1
Entamoeba histolytica	cysteine proteinase, putative	0.0654	0.2382	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.028	0.091	0.091
Echinococcus granulosus	cathepsin L	0.0654	0.2382	0.1619
Loa Loa (eye worm)	hypothetical protein	0.1202	0.454	0.454
Onchocerca volvulus		0.1202	0.454	1
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.028	0.091	0.091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.1202	0.454	0.454
Loa Loa (eye worm)	ctsf protein	0.1202	0.454	0.454
Echinococcus granulosus	cysteine protease	0.0654	0.2382	0.1619
Onchocerca volvulus		0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.0828	0.3068	0.3068
Entamoeba histolytica	cysteine proteinase 2	0.0654	0.2382	0.4054
Plasmodium vivax	vivapain-2	0.1202	0.454	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1202	0.454	0.3993
Leishmania major	cysteine peptidase A (CPA)	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1202	0.454	0.3993
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2589	1	1
Brugia malayi	Cathepsin L-like precursor	0.1202	0.454	0.454
Brugia malayi	cathepsin L precursor	0.028	0.091	0.091
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0994	0.3721	0.3093
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0828	0.3068	0.3068
Trypanosoma cruzi	cruzipain precursor, putative	0.1202	0.454	0.3993
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0654	0.2382	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Onchocerca volvulus		0.1202	0.454	1
Echinococcus multilocularis	cathepsin b	0.2589	1	1
Echinococcus granulosus	cathepsin b	0.2589	1	1
Onchocerca volvulus		0.1202	0.454	1
Onchocerca volvulus		0.1202	0.454	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1202	0.454	0.3993
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1202	0.454	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1202	0.454	0.454
Echinococcus multilocularis	cathepsin L cysteine protease	0.1202	0.454	0.3993
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Brugia malayi	fibroinase precursor	0.028	0.091	0.091
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.028	0.091	0.091
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1202	0.454	0.3993
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0654	0.2382	0.1619
Plasmodium vivax	unspecified product	0.0654	0.2382	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0828	0.3068	0.3068
Loa Loa (eye worm)	hypothetical protein	0.2589	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Onchocerca volvulus	Cathepsin L homolog	0.1202	0.454	1
Brugia malayi	Papain family cysteine protease containing protein	0.0654	0.2382	0.2382
Brugia malayi	cathepsin L-like precursor	0.0828	0.3068	0.3068
Trypanosoma cruzi	cruzipain precursor, putative	0.0374	0.1279	0.0406
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1202	0.454	0.454
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Loa Loa (eye worm)	hypothetical protein	0.0374	0.1279	0.1279
Entamoeba histolytica	cysteine proteinase, putative	0.0828	0.3068	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.1202	0.454	0.3993
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1202	0.454	1
Echinococcus multilocularis	cathepsin L	0.0654	0.2382	0.1619
Trypanosoma cruzi	cysteine peptidase, putative	0.0374	0.1279	0.0406
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Loa Loa (eye worm)	fibroinase	0.1202	0.454	0.454
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0828	0.3068	0.2374
Echinococcus multilocularis	cysteine protease	0.1202	0.454	0.3993
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Brugia malayi	Papain family cysteine protease containing protein	0.1202	0.454	0.454
Loa Loa (eye worm)	hypothetical protein	0.028	0.091	0.091
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0654	0.2382	0.1619
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Onchocerca volvulus	Cathepsin F homolog	0.1202	0.454	1
Entamoeba histolytica	cysteine proteinase, putative	0.0654	0.2382	0.4054
Loa Loa (eye worm)	hypothetical protein	0.028	0.091	0.091
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2589	1	1
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.091	0.091
Plasmodium vivax	vivapain-2	0.1202	0.454	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0654	0.2382	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Entamoeba histolytica	cysteine protease, putative	0.1202	0.454	1
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.028	0.091	0.091
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Giardia lamblia	Cathepsin B precursor	0.0994	0.3721	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.091	0.091
Loa Loa (eye worm)	hypothetical protein	0.028	0.091	0.091
Brugia malayi	Papain family cysteine protease containing protein	0.0654	0.2382	0.2382
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.1202	0.454	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0994	0.3721	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.1202	0.454	0.3993
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Schistosoma mansoni	cathepsin s	0.0374	0.1279	0.0406
Brugia malayi	Cathepsin L-like precursor	0.1202	0.454	0.454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.1202	0.454	0.454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0795	0.2938	0.2231
Trypanosoma cruzi	cysteine peptidase, putative	0.0654	0.2382	0.1619
Echinococcus granulosus	cathepsin L cysteine protease	0.0654	0.2382	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0828	0.3068	0.3068
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0654	0.2382	0.4054
Echinococcus granulosus	cathepsin l1	0.1202	0.454	0.3993
Toxoplasma gondii	cathepsin B	0.0994	0.3721	0.7745
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1202	0.454	0.3993
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0828	0.3068	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Onchocerca volvulus		0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2589	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.1202	0.454	0.454
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1202	0.454	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0994	0.3721	0.7745
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0654	0.2382	0.1619
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0374	0.1279	0.1279
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2589	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1202	0.454	0.3993
Plasmodium vivax	unspecified product	0.0374	0.1279	0.1017
Toxoplasma gondii	cathepsin CPL	0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.0374	0.1279	0.1279
Entamoeba histolytica	cysteine proteinase, putative	0.0654	0.2382	0.4054
Echinococcus multilocularis	cysteine protease	0.1202	0.454	0.3993
Loa Loa (eye worm)	hypothetical protein	0.028	0.091	0.091
Loa Loa (eye worm)	hypothetical protein	0.0374	0.1279	0.1279
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0374	0.1279	0.1279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Entamoeba histolytica	cysteine proteinase, putative	0.0654	0.2382	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.028	0.091	0.091
Onchocerca volvulus		0.0828	0.3068	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0374	0.1279	0.1279
Entamoeba histolytica	cysteine proteinase, putative	0.1202	0.454	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.028	0.091	0.091
Schistosoma mansoni	cathepsin F (C01 family)	0.1202	0.454	0.3993
Brugia malayi	Papain family cysteine protease containing protein	0.028	0.091	0.091
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0654	0.2382	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0654	0.2382	0.1619
Plasmodium vivax	vivapain-1	0.0654	0.2382	0.4054
Leishmania major	cathepsin L-like protease	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Loa Loa (eye worm)	cysteine protease	0.1202	0.454	0.454
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0994	0.3721	0.6208
Plasmodium vivax	vivapain-3	0.0654	0.2382	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0374	0.1279	0.1279
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0828	0.3068	0.5946
Brugia malayi	cathepsin F-like cysteine proteinase	0.028	0.091	0.091
Brugia malayi	cathepsin Z-like cysteine proteinase	0.028	0.091	0.091
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1202	0.454	0.3993
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1202	0.454	0.3993
Trypanosoma cruzi	cysteine proteinase, putative	0.0654	0.2382	0.1619
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054
Loa Loa (eye worm)	cathepsin B	0.0994	0.3721	0.3721
Echinococcus granulosus	cathepsin l1	0.0828	0.3068	0.2374
Brugia malayi	Papain family cysteine protease containing protein	0.028	0.091	0.091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Brugia malayi	Cathepsin L-like precursor	0.0828	0.3068	0.3068
Loa Loa (eye worm)	hypothetical protein	0.0828	0.3068	0.3068
Echinococcus multilocularis	cathepsin b	0.2589	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1202	0.454	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1202	0.454	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0828	0.3068	0.2374
Trypanosoma cruzi	cysteine proteinase, putative	0.0654	0.2382	0.1619
Brugia malayi	cathepsin L-like cysteine proteinase	0.028	0.091	0.091
Onchocerca volvulus	Cathepsin L homolog	0.1202	0.454	1
Giardia lamblia	Cathepsin B precursor	0.0994	0.3721	1
Giardia lamblia	Cathepsin B precursor	0.0994	0.3721	1
Entamoeba histolytica	cysteine protease, putative	0.0654	0.2382	0.4054

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 895855