Detailed information for compound 895935

Basic information

Technical information
  • TDR Targets ID: 895935
  • Name: 2-[4-(4-methylphenyl)-1,3-thiazol-2-yl]pyridi ne
  • MW: 252.334 | Formula: C15H12N2S
  • H donors: 0 H acceptors: 2 LogP: 3.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1csc(n1)c1ccccn1
  • InChi: 1S/C15H12N2S/c1-11-5-7-12(8-6-11)14-10-18-15(17-14)13-4-2-3-9-16-13/h2-10H,1H3
  • InChiKey: UEFFIKGPZCFIHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(4-methylphenyl)thiazol-2-yl]pyridine
  • 2-[4-(4-methylphenyl)-2-thiazolyl]pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0613 0.0803
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0114
Schistosoma mansoni fatty-acid amide hydrolase 0.0038 0.0838 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Echinococcus multilocularis muscleblind protein 0.0151 0.3591 0.3591
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Trypanosoma cruzi serine peptidase, putative 0.0014 0.0248 0.0432
Brugia malayi nuclear receptor RXR 0.0005 0.0036 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0154 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0154 0.0201
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0022 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0022 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0248 0.0432
Leishmania major hypothetical protein, conserved 0.0014 0.0248 0.0432
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0154 0.0201
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0036 0.0036
Brugia malayi MGC83647 protein 0.0014 0.0248 0.0324
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0014 0.0248 0.0248
Chlamydia trachomatis acyltransferase family protein 0.0014 0.0248 0.2956
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0154 0.0201
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0154 0.0154
Mycobacterium ulcerans amidase 0.0038 0.0838 0.1463
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0038 0.0838 1
Echinococcus multilocularis muscleblind protein 1 0.0151 0.3591 0.3591
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0248 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0154 0.0201
Loa Loa (eye worm) hypothetical protein 0.0316 0.764 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Entamoeba histolytica hypothetical protein 0.0014 0.0248 0.0432
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0038 0.0838 0.1077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0154 0.0154
Toxoplasma gondii hypothetical protein 0.0014 0.0248 0.1985
Schistosoma mansoni fatty-acid amide hydrolase 0.0316 0.764 0.764
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0038 0.0838 0.0838
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0014 0.0248 0.0432
Schistosoma mansoni nuclear hormone receptor 0.001 0.0154 0.0154
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0154 0.0154
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0038 0.0838 0.0838
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0036 0.0036
Brugia malayi ecdysone receptor 0.0005 0.0022 0.0029
Schistosoma mansoni cpg binding protein 0.0029 0.0613 0.0613
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0014 0.0248 0.1985
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0154 0.0201
Brugia malayi Amidase family protein 0.0038 0.0838 0.1096
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0022 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0413 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0816 0.1425
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Brugia malayi hypothetical protein 0.0005 0.0022 0.0029
Brugia malayi Muscleblind-like protein 0.0151 0.3591 0.4701
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0081 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0022 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0081 0.0081
Loa Loa (eye worm) inositol-1 0.0037 0.0816 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Toxoplasma gondii peptidase S15, putative 0.0014 0.0248 0.1985
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0248 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0154 0.0201
Echinococcus granulosus Phospholipase carboxylesterase 0.0014 0.0248 0.0248
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0022 0.0029
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0022 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0238 0.5726 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0154 0.0154
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0022 0.0022
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0014 0.0248 0.0432
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0154 0.0154
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0036 0.0047
Brugia malayi steroid hormone receptor 0.001 0.0154 0.0201
Toxoplasma gondii hypothetical protein 0.0014 0.0248 0.1985
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0022 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0154 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0154 0.251
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1247 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0816 0.1425
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0154 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0154 0.0201
Entamoeba histolytica hypothetical protein 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0248 0.0324
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0036 0.0047
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0014 0.0248 0.0432
Plasmodium falciparum esterase, putative 0.0238 0.5726 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0248 0.0432
Mycobacterium ulcerans amidase 0.0038 0.0838 0.1463
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0014 0.0248 0.0432
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0238 0.5726 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0154 0.0201
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0038 0.0838 0.1463
Echinococcus multilocularis abhydrolase domain containing 3 0.0014 0.0248 0.0248
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0038 0.0838 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0154 0.251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0124 0.0124
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0154 0.0201
Toxoplasma gondii hypothetical protein 0.0014 0.0248 0.1985
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0038 0.0838 0.1463
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0014 0.0248 0.0432
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0022 0.0022
Brugia malayi hypothetical protein 0.0005 0.0036 0.0047
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0014 0.0248 0.0248
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0038 0.0838 0.1463
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0816 0.1425
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0154 0.0154
Onchocerca volvulus 0.001 0.0154 0.251
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0151 0.3591 0.4701
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0065 0.0114
Mycobacterium ulcerans lysophospholipase 0.0238 0.5726 1
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0022 0.0361
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0014 0.0248 0.0432
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0038 0.0838 0.1077
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0038 0.0838 0.1463
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0014 0.0248 0.0432
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0816 0.1425
Brugia malayi CXXC zinc finger family protein 0.0029 0.0613 0.0803
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0014 0.0248 0.0248
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0721 0.1258
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0816 0.1425
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0022 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0154 0.0201
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0014 0.0248 0.1985
Brugia malayi hypothetical protein 0.0005 0.0036 0.0047
Brugia malayi hypothetical protein 0.0005 0.0022 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Echinococcus multilocularis cpg binding protein 0.0031 0.0654 0.0654
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0121 0.0158
Leishmania major hypothetical protein, conserved 0.0014 0.0248 0.0432
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0014 0.0248 0.0432
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0816 0.6542
Toxoplasma gondii phospholipase 0.0014 0.0248 0.1985
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0022 0.0029
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0238 0.5726 1
Brugia malayi tailless protein 0.0005 0.0022 0.0029
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0038 0.0838 0.5
Schistosoma mansoni coup transcription factor 0.001 0.0154 0.0154
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0038 0.0838 0.1463
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0154 0.0201
Onchocerca volvulus 0.0029 0.0613 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0154 0.0201
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Schistosoma mansoni nuclear receptor 0.0005 0.0022 0.0022
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0022 0.0029
Echinococcus granulosus muscleblind protein 0.0151 0.3591 0.3591
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0036 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Schistosoma mansoni inositol monophosphatase 0.0037 0.0816 0.0816
Toxoplasma gondii protein c14orf29, putative 0.0014 0.0248 0.1985
Plasmodium falciparum lysophospholipase, putative 0.0238 0.5726 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0154 0.0201
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Plasmodium vivax PST-A protein 0.0238 0.5726 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0238 0.5726 1
Brugia malayi Amidase family protein 0.0038 0.0838 0.1096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0114
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0154 0.251
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0022 0.0022
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0022 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0238 0.5726 1
Schistosoma mansoni amidase 0.0316 0.764 0.764
Trichomonas vaginalis helicase, putative 0.0007 0.0065 0.0114
Schistosoma mansoni nuclear receptor 0.0005 0.0022 0.0022
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0014 0.0248 0.0432
Toxoplasma gondii hypothetical protein 0.0014 0.0248 0.1985
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0022 0.0022
Mycobacterium ulcerans hydrolase 0.0014 0.0248 0.0432
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0816 0.1425
Loa Loa (eye worm) DR-78 0.0005 0.0022 0.0029
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0816 0.0816
Schistosoma mansoni hypothetical protein 0.0413 1 1
Loa Loa (eye worm) amidase 0.0038 0.0838 0.1096
Mycobacterium ulcerans amidase 0.0038 0.0838 0.1463
Mycobacterium ulcerans peptide amidase, GatA 0.0038 0.0838 0.1463
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0114
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0316 0.764 0.764
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0022 0.0029
Schistosoma mansoni peptidase 0.0014 0.0248 0.0248
Trypanosoma cruzi monoglyceride lipase, putative 0.0238 0.5726 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0154 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0005 0.0036 0.0047
Echinococcus granulosus abhydrolase domain containing 3 0.0014 0.0248 0.0248
Brugia malayi Inositol-1 0.0037 0.0816 0.1068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0114
Trypanosoma cruzi serine peptidase, putative 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0248 0.0324
Echinococcus granulosus fatty acid amide hydrolase 1 0.0316 0.764 0.764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0154 0.0201
Chlamydia trachomatis hydrolase 0.0014 0.0248 0.2956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0154 0.0201
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0081 0.0081
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0154 0.0154
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0038 0.0838 0.1463
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0038 0.0838 0.1463
Entamoeba histolytica ;Alias 0.0014 0.0248 0.0432
Echinococcus granulosus fatty acid amide hydrolase 1 0.0038 0.0838 0.0838
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0014 0.0248 0.1985
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0154 0.0201
Loa Loa (eye worm) hypothetical protein 0.0005 0.0036 0.0047
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0038 0.0838 0.1463
Trypanosoma brucei monoglyceride lipase, putative 0.0238 0.5726 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Brugia malayi nuclear receptor RXR 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0248 0.0324
Brugia malayi conserved hypotetical protein 0.0005 0.0022 0.0029
Onchocerca volvulus 0.0005 0.0022 0.0361
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0154 0.0154
Brugia malayi putative amidase 0.0038 0.0838 0.1096
Leishmania major monoglyceride lipase, putative 0.0238 0.5726 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0124 0.0162
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0816 0.1425
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0154 0.0201
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0154 0.0154
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0816 0.1425
Brugia malayi MGC79044 protein 0.0014 0.0248 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0065 0.0114
Mycobacterium tuberculosis Possible lysophospholipase 0.0238 0.5726 1
Schistosoma mansoni cpg binding protein 0.0031 0.0654 0.0654
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0038 0.0838 0.1463
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0038 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0006 0.0006
Plasmodium falciparum lysophospholipase, putative 0.0238 0.5726 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0014 0.0248 0.0324
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Echinococcus granulosus fatty acid amide hydrolase 1 0.0316 0.764 0.764
Trypanosoma brucei monoglyceride lipase, putative 0.0238 0.5726 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0154 0.0154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0014 0.0248 0.0432
Loa Loa (eye worm) hypothetical protein 0.0005 0.0036 0.0047
Brugia malayi nuclear receptor NHR-88 0.0005 0.0022 0.0029
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0238 0.5726 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0154 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1408 0.1408
Mycobacterium ulcerans amidase 0.0038 0.0838 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Schistosoma mansoni inositol monophosphatase 0.0037 0.0816 0.0816
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0022 0.0022
Trypanosoma cruzi amidase, putative 0.0038 0.0838 0.1463
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0316 0.764 0.764
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0154 0.0154
Onchocerca volvulus 0.0005 0.0022 0.0361
Brugia malayi amidase 0.0316 0.764 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0154 0.0154
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0038 0.0838 0.1463
Mycobacterium ulcerans hypothetical protein 0.0238 0.5726 1
Loa Loa (eye worm) amidase 0.0038 0.0838 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0154 0.0201
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0154 0.0154
Toxoplasma gondii phospholipase/carboxylesterase 0.0014 0.0248 0.1985
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0151 0.3591 0.4701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0154 0.0201
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Echinococcus granulosus FTZ F1 alpha 0.001 0.0154 0.0154
Trypanosoma cruzi amidase, putative 0.0038 0.0838 0.1463
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0014 0.0248 0.0432
Brugia malayi ecdysteroid receptor 0.001 0.0154 0.0201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0022 0.0361
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0816 0.1425
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0238 0.5726 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0154 0.0154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0154 0.0154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0005 0.0036 0.0047
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0036 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Mycobacterium ulcerans amidase 0.0038 0.0838 0.1463
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0154 0.0201
Loa Loa (eye worm) hypothetical protein 0.0005 0.0022 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0154 0.0154
Mycobacterium ulcerans hypothetical protein 0.0014 0.0248 0.0432
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0014 0.0248 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0065 0.0114
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0036 0.0036
Plasmodium falciparum lysophospholipase, putative 0.0238 0.5726 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0065 0.0114
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0022 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.5726 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0036 0.0047
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0038 0.0838 0.0838
Echinococcus granulosus cpg binding protein 0.0031 0.0654 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.5726 1
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0014 0.0248 0.0248
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0238 0.5726 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0154 0.0201
Brugia malayi nuclear hormone receptor 0.0005 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.0154 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0022 0.0022
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0014 0.0248 0.0432
Mycobacterium ulcerans hypothetical protein 0.0014 0.0248 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0248 0.0432
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0721 0.1258
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0238 0.5726 1
Echinococcus multilocularis Phospholipase carboxylesterase 0.0014 0.0248 0.0248
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0154 0.0154
Schistosoma mansoni thyroid hormone receptor 0.001 0.0154 0.0154
Brugia malayi Protein C20orf22 0.0014 0.0248 0.0324
Brugia malayi nuclear receptor NHR-88 0.001 0.0154 0.0201
Brugia malayi nuclear receptor NHR-67 0.0005 0.0022 0.0029
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0031 0.0654 0.0654
Brugia malayi nuclear hormone receptor 0.001 0.0154 0.0201
Schistosoma mansoni zinc finger protein 0.0005 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0154 0.0201
Echinococcus granulosus abhydrolase domain containing protein 13 0.0014 0.0248 0.0248
Schistosoma mansoni thyroid hormone receptor 0.001 0.0154 0.0154

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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