Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0151 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0071 | 0.3204 | 0.3204 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0116 | 0.7024 | 0.7024 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0151 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0151 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.3193 | 0.3193 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0071 | 0.3204 | 0.3204 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.008 | 0.3931 | 0.3931 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | tailless protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | nuclear receptor NHR-88 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0151 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0151 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0071 | 0.3204 | 0.3204 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0151 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Brugia malayi | conserved hypotetical protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0071 | 0.3204 | 0.3204 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0071 | 0.3204 | 0.3204 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.008 | 0.3931 | 0.3931 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0151 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | nuclear receptor RXR | 0.008 | 0.3931 | 0.3931 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.3193 | 0.3193 |
Brugia malayi | steroid hormone receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0151 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0151 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0151 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0071 | 0.3204 | 0.3204 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0151 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0151 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0071 | 0.3204 | 0.3204 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | DR-78 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0071 | 0.3204 | 0.3204 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.008 | 0.3931 | 0.3931 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0151 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0151 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0116 | 0.7024 | 0.7024 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0071 | 0.3204 | 0.3204 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5718 | 0.5718 |
Schistosoma mansoni | nuclear receptor | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0151 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | nuclear receptor NHR-67 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0151 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0071 | 0.3204 | 0.3204 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.008 | 0.3931 | 0.3931 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0151 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0151 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0151 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0071 | 0.3204 | 0.3204 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0071 | 0.3204 | 0.3204 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0116 | 0.7024 | 0.7024 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0109 | 0.6374 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0127 | 0.7933 | 0.7933 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.008 | 0.3931 | 0.3931 |
Brugia malayi | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0151 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Onchocerca volvulus | 0.0151 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0127 | 0.7933 | 0.7933 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0151 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0109 | 0.6374 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0151 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0116 | 0.7024 | 0.7024 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.008 | 0.3931 | 0.3931 |
Brugia malayi | nuclear hormone receptor | 0.0151 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0071 | 0.3204 | 0.3204 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0151 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0151 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | nuclear receptor NHR-88 | 0.0151 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.008 | 0.3931 | 0.3931 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0151 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3931 | 0.3931 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0151 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0151 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0071 | 0.3204 | 0.3204 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0151 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0071 | 0.3204 | 0.3204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.