Detailed information for compound 896132

Basic information

Technical information
  • TDR Targets ID: 896132
  • Name: 2-[(4-fluorophenyl)amino]-6-propyl-1H-pyrimid in-4-one
  • MW: 247.268 | Formula: C13H14FN3O
  • H donors: 2 H acceptors: 3 LogP: 3.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc(Nc2ccc(cc2)F)nc(c1)O
  • InChi: 1S/C13H14FN3O/c1-2-3-11-8-12(18)17-13(16-11)15-10-6-4-9(14)5-7-10/h4-8H,2-3H2,1H3,(H2,15,16,17,18)
  • InChiKey: FDMYRHFIMCLVIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC01281451
  • ST5326183

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0165 0.3893 0.3216
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2155 1
Trypanosoma brucei glucose transporter 2A 0.0033 0 0.5
Echinococcus multilocularis excitatory amino acid transporter 2 0.0371 1 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0165 0.3893 0.3859
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0165 0.3893 0.3216
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0371 1 0.5
Trypanosoma cruzi hexose transporter 0.0033 0 0.5
Schistosoma mansoni glucose transport protein 0.0106 0.2155 0.2111
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0 0.5
Echinococcus granulosus Excitatory amino acid transporter 0.0371 1 1
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Echinococcus multilocularis neutral amino acid transporter A 0.0371 1 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.2475 0.2433
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Schistosoma mansoni hypothetical protein 0.0106 0.2155 0.2111
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2155 0.5
Loa Loa (eye worm) sugar transporter 0.0106 0.2155 0.2111
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0371 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0 0.5
Plasmodium falciparum hexose transporter 0.0106 0.2155 0.5
Echinococcus granulosus excitatory amino acid transporter 3 0.0371 1 1
Schistosoma mansoni integrin alpha 0.0148 0.3418 0.3381
Trypanosoma cruzi hexose transporter, putative 0.0033 0 0.5
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0165 0.3893 0.3859
Echinococcus granulosus sodium:dicarboxylate symporter 0.0371 1 1
Plasmodium vivax hexose transporter 0.0106 0.2155 0.5
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.3418 0.161
Echinococcus multilocularis excitatory amino acid transporter 3 0.0371 1 1
Echinococcus multilocularis General substrate transporter 0.0091 0.1715 0.0797
Schistosoma mansoni integrin alpha-ps 0.0067 0.0998 0.0948
Schistosoma mansoni glucose transport protein 0.0106 0.2155 0.2111
Echinococcus granulosus excitatory amino acid transporter 2 0.0371 1 1
Echinococcus granulosus neutral amino acid transporter A 0.0371 1 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0 0.5
Echinococcus multilocularis Excitatory amino acid transporter 0.0371 1 1
Loa Loa (eye worm) excitatory amino acid transporter 0.0371 1 1
Echinococcus granulosus neutral amino acid transporter 0.0371 1 1
Echinococcus multilocularis neutral amino acid transporter A 0.0371 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Treponema pallidum glutamate transporter 0.0165 0.3893 0.5
Echinococcus granulosus excitatory amino acid transporter 2 0.0371 1 1
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Echinococcus granulosus Excitatory amino acid transporter 0.0371 1 1
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Treponema pallidum glutamate/aspartate transporter 0.0165 0.3893 0.5
Echinococcus multilocularis neutral amino acid transporter A 0.0371 1 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0371 1 0.5
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Trypanosoma brucei glucose transporter 1E 0.0033 0 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Loa Loa (eye worm) hypothetical protein 0.0112 0.2349 0.2307
Echinococcus granulosus integrin alpha 3 0.0114 0.2394 0.1551
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2155 0.1285
Echinococcus granulosus neutral amino acid transporter A 0.0371 1 1
Chlamydia trachomatis glutamate symporter 0.0371 1 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0 0.5
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0371 1 0.5
Echinococcus multilocularis excitatory amino acid transporter 2 0.0371 1 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0371 1 1
Schistosoma mansoni glucose transport protein 0.0106 0.2155 0.2111
Leishmania major glucose transporter, lmgt1 0.0033 0 0.5
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0371 1 1
Leishmania major glucose transporter, lmgt3 0.0033 0 0.5
Echinococcus granulosus General substrate transporter 0.0091 0.1715 0.0797
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5
Leishmania major glucose transporter, lmgt2 0.0033 0 0.5
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.2349 0.0248
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2155 0.1285
Loa Loa (eye worm) integrin alpha pat-2 0.0229 0.5793 0.577
Loa Loa (eye worm) hypothetical protein 0.0082 0.1451 0.1404
Echinococcus multilocularis integrin alpha 3 0.0114 0.2394 0.1551
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0371 1 1
Trypanosoma brucei glucose transporter, putative 0.0033 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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